Biofunctional rapid prototyping for tissue‐engineering applications: 3D bioplotting versus 3D printing

Pfister, Andreas; Landers, Rüdiger; Laib, Andres; Hübner, U.; Schmelzeisen, Rainer; Mülhaupt, Rolf

doi:10.1002/pola.10807

Cited by 256 publications

(171 citation statements)

References 13 publications

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“…Different scaffold fabrication techniques can generate structures with a certain control over the mechanical properties of the resulting cellular solids [23,[50][51][52]. However, rapid prototyping technologies offer undoubtedly the possibility to more precisely control not only their mechanical properties, but also their pore network architecture and their custom shape [15,[53][54][55]. Scaffolds with simplified shapes were also fabricated and mechanically tested.…”

Section: Maximal Fibril Strainmentioning

confidence: 99%

Finite Element Analysis of Meniscal Anatomical 3D Scaffolds: Implications for Tissue Engineering

Moroni¹,

Lambers²,

Wilson³

et al. 2007

TOBEJ

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Solid Free-Form Fabrication (SFF) technologies allow the fabrication of anatomical 3D scaffolds from computer tomography (CT) or magnetic resonance imaging (MRI) patients' dataset. These structures can be designed and fabricated with a variable, interconnected and accessible porous network, resulting in modulable mechanical properties, permeability, and architecture that can be tailored to mimic a specific tissue to replace or regenerate. In this study, we evaluated whether anatomical meniscal 3D scaffolds with matching mechanical properties and architecture are beneficial for meniscus replacement as compared to meniscectomy. After acquiring CT and MRI of porcine menisci, 3D fiber-deposited (3DF) scaffolds were fabricated with different architectures by varying the deposition pattern of the fibers comprising the final structure. The mechanical behaviour of 3DF scaffolds with different architectures and of porcine menisci was measured by static and dynamic mechanical analysis and the effect of these tissue engineering templates on articular cartilage was assessed by finite element analysis (FEA) and compared to healthy conditions or to meniscectomy. Results show that 3DF anatomical menisci scaffolds can be fabricated with pore different architectures and with mechanical properties matching those of natural menisci. FEA predicted a beneficial effect of meniscus replacement with 3D scaffolds in different mechanical loading conditions as compared to meniscectomy. No influence of the internal scaffold architecture was found on articular cartilage damage. Although FEA predictions should be further confirmed by in vitro and in vivo experiments, this study highlights meniscus replacement by SFF anatomical scaffolds as a potential alternative to meniscectomy.

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Section: Maximal Fibril Strainmentioning

confidence: 99%

Finite Element Analysis of Meniscal Anatomical 3D Scaffolds: Implications for Tissue Engineering

Moroni¹,

Lambers²,

Wilson³

et al. 2007

TOBEJ

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“…As for macroporosity, it forms 3D complex structures, which encourages migration and proliferation of osteogenic cells, as well as reinforces mechanical connection with adjacent tissues [4,12,17]. Nevertheless, it has presented limitations in existing traditional technologies due to uncontrollable distribution and sizes of pores in scaffolds [18][19][20], and recently developed 3D printing techniques are not capable of producing microporosity in nano scale [21][22][23]. Hence it is almost impossible to fabricate scaffolds with refined structures consisting of porosity across macro, micron and nano scale (nm -μm -mm) through these methods.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of 3D complex hydroxyapatite scaffolds with hierarchical porosity of different features for optimal bioactive performance

Chen

Zhang

Yang

et al. 2017

Ceramics International

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“…This technique also allows prototyping at body temperature, especially of interest if living cells are incorporated into the plotting material. A comparison between the rapid prototyping techniques for tissue engineering applications can be found elsewhere [21].…”

Section: Introductionmentioning

confidence: 99%

Design and fabrication of 3D‐plotted polymeric scaffolds in functional tissue engineering

Yousefi¹,

Gauvin²,

Sun³

et al. 2007

Polymer Engineering & Sci

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Regenerating the load‐bearing tissues requires 3D scaffolds that balance the temporary mechanical function with the biological requirements. In functional tissue engineering, designing scaffolds with biomimetic mechanical properties could promote tissue ingrowth since the cells are sensitive to their local mechanical environment. This work aims to design scaffolds that mimic the mechanical response of the biological tissues under physiological loading conditions. Poly(L‐lactide) (PLLA) scaffolds with varying porosities and pore sizes were made by the 3D‐plotting technique. The scaffolds were tested under unconfined ramp compression to compare their stress profile under load with that of bovine cartilage. A comparison between the material parameters estimated for the scaffolds and for the bovine cartilage based on the biphasic theory enabled the definition of an optimum window for the porosity and pore size of these constructs. Moreover, the finite element prediction for the stress distribution inside the scaffolds, surrounded by the host cartilaginous tissue, demonstrated a negligible perturbation of the stress field at the site of implantation. The finite element modeling tools in combination with the developed methodology for optimal porosity/pore size determination can be used to improve the design of biomimetic scaffolds. POLYM. ENG. SCI., 47:608–618, 2007. © 2007 Society of Plastics Engineers.

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Biofunctional rapid prototyping for tissue‐engineering applications: 3D bioplotting versus 3D printing

Cited by 256 publications

References 13 publications

Finite Element Analysis of Meniscal Anatomical 3D Scaffolds: Implications for Tissue Engineering

Finite Element Analysis of Meniscal Anatomical 3D Scaffolds: Implications for Tissue Engineering

Fabrication and characterization of 3D complex hydroxyapatite scaffolds with hierarchical porosity of different features for optimal bioactive performance

Design and fabrication of 3D‐plotted polymeric scaffolds in functional tissue engineering

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