Biofunctionalization of electrospun poly(caprolactone) fibers with Maillard reaction products for wound dressing applications

Simões, Déborah; Miguel, Sónia P.; Correia, Ilídio J.

doi:10.1016/j.reactfunctpolym.2018.07.021

Cited by 25 publications

(12 citation statements)

References 91 publications

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“…A large number of studies have shown that MRPs are related to the immune system. The conformational epitome of MRPs is recognized by pattern recognition (PRRs) on the surface of human immune cells, and signals are transmitted to the nucleus, whereupon the nuclear factor kappa‐b (NF‐kB) is activated (Simões, Miguel, & Correia, 2018). The immune system is involved in cell response to external stimuli and makes extracellular responses (Muscat, Pelka, Jörg, Weigle, & Pischetsrieder, 2010).…”

Section: Biological Activity Of Mr Productsmentioning

confidence: 99%

Maillard conjugates and their potential in food and nutritional industries: A review

Liu

Xia

et al. 2020

Food Frontiers

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Maillard reaction (MR) is a cascade of complex interactions between reducing sugars and amine groups in food processing and storage. It produces a variety of volatile compound, nonenzymatic intermediates, and high molecular weight melanoidin contributing improved aroma, color, flavor, and antioxidant properties to the final food products. When uncontrolled, it can produce some harmful derivatives such as acrylamide, heterocyclic amine, advanced glycation end Products (AGEs), and other substances that can be detrimental to human health leading to cancer and chronic diseases. Herein, we reviewed the MR leading to different MRPs and factors affecting the MR and MRPs, their application in food model systems, their biological activities, and the formation mechanism and effective inhibition methods of common harmful MRPs. The updated overview can be useful to explore the rational use of MR, which can ameliorate its positive biological features with reduced adverse effects.

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Section: Biological Activity Of Mr Productsmentioning

confidence: 99%

Maillard conjugates and their potential in food and nutritional industries: A review

Liu

Xia

et al. 2020

Food Frontiers

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“…The SEM images were obtained using the Hitachi S-3400 N Scanning Electron Microscope (Hitachi, Tokyo, Japan), at an accelerating voltage of 20 kV. The nanofibers' diameters were measured using an image analysis software -Image J (Scion Corp., Frederick, MD) (Simões et al, 2018a).…”

Section: Characterization Of the Solutions' Properties And Membranes' Morphologymentioning

confidence: 99%

“…The swelling capacity of the produced membranes was determined by immersing them in a PBS solution at pH 5 (pH of native skin) or pH 8 (pH displayed by injured skin), at 37°C under stirring (40 rpm) (Miguel et al, 2019b;Simões et al, 2018a). After, the excess of PBS was removed with a filter paper, the samples (n = 5) were weighted.…”

Section: Evaluation Of the Membranes' Swelling Capacitymentioning

confidence: 99%

“…The antioxidant activity of the membranes was evaluated through the 2-diphenly-1-picrylhydrazyl (DPPH) radical scavenging assay, as previously described in the literature (Miguel et al, 2019b;Simões et al, 2018a). To perform this assay, membrane samples (5 mg; n = 5) were immersed in 3 mL of DPPH solution (100 µM) in methanol and incubated in a dark room, at RT during 30 min.…”

Section: Evaluation Of the Membranes' Antioxidant Capacitymentioning

confidence: 99%

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Development of a poly(vinyl alcohol)/lysine electrospun membrane-based drug delivery system for improved skin regeneration

Sequeira

Miguel

Cabral

et al. 2019

International Journal of Pharmaceutics

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Nanofiber-based wound dressings are currently being explored as delivery systems of different biomolecules for avoiding skin infections as well as improve/accelerate the healing process. In the present work, a nanofibrous membrane composed of poly(vinyl alcohol) (PVA) and lysine (Lys) was produced by using the electrospinning technique. Further, anti-inflammatory (ibuprofen (IBP)) and antibacterial (lavender oil (LO)) agents were incorporated within the electrospun membrane through blend electrospinning and surface physical adsorption methods, respectively. The obtained results demonstrated that the PVA_Lys electrospun membranes incorporating IBP or LO displayed the suitable morphological, mechanical and biological properties for enhancing the wound healing process. Moreover, the controlled and sustained release profile attained for IBP was appropriate for the duration of the wound healing inflammatory phase, whereas the initial burst release of LO is crucial to prevent wound bacterial contamination. Indeed, the PVA_Lys_LO electrospun membranes were able to mediate a strong antibacterial activity against both S. aureus and P. aeruginosa, without compromising human fibroblasts viability. Overall, the gathered data emphasizes the potential of the PVA_Lys electrospun membranesbased drug delivery systems to be used as wound dressings.

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“…The discovery of electrospun nanofiber materials has resulted in a broad spectrum of useful applications within heterogeneous catalysis, water purification, air filtration, energy conversion/harvesting/storage, smart textiles, tissue engineering, regenerative medicine, sensors for biological sensing, and drug delivery [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16]. Depending on the application various properties need to be carefully controlled, e.g.…”

Section: Introductionmentioning

confidence: 99%

Controlling surface properties of electrospun polyphenylsulfone using plasma treatment and X-ray photoelectron spectroscopy

Norrman

Wang

Stamate

et al. 2019

Heliyon

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Plasma treatment is an efficient method to modify organic surfaces. In this work electrospun polyphenylsulfone was systematically subjected to low-pressure microwave plasma and atmospheric-pressure coplanar barrier discharge in order to control the surface chemistry, which is important for controlling surface properties. Polar anchor groups such as keto/aldehyde groups and especially carboxylic acid groups affect hydrophilicity. The composition of plasma-induced chemical anchor groups can be monitored (and thus controlled) by X-ray photoelectron spectroscopy. The atmospheric-pressure plasma provided subtle oxidation, and the low-pressure plasma provided significant oxidation that resulted in polyphenylsulfone surfaces with a very high hydrophilicity. The low-pressure plasma treated polyphenylsulfone exhibited a significant age effect over 212 days, which was attributed to a diffusion phenomenon where the polyphenylsulfone surface becomes enriched in non-oxidated polyphenylsulfone. It was shown that the improved hydrophilicity will diminish but not vanish in time.

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Biofunctionalization of electrospun poly(caprolactone) fibers with Maillard reaction products for wound dressing applications

Cited by 25 publications

References 91 publications

Maillard conjugates and their potential in food and nutritional industries: A review

Maillard conjugates and their potential in food and nutritional industries: A review

Development of a poly(vinyl alcohol)/lysine electrospun membrane-based drug delivery system for improved skin regeneration

Controlling surface properties of electrospun polyphenylsulfone using plasma treatment and X-ray photoelectron spectroscopy

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