Biofunctionalized 3D printed structures for biomedical applications: A critical review of recent advances and future prospects

Lotz, Oliver; McKenzie, David R.; Bilek, M.M.M.; Akhavan, Behnam

doi:10.1016/j.pmatsci.2023.101124

Cited by 20 publications

(7 citation statements)

References 337 publications

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“…3D printing in tissue engineering was first designed as a scaffold for cell culture, 278 and with the development of technology and materials, 3D printing in tissue repair gradually evolved into bioprinting. 279–281 Bioprinting is the precise three-dimensional structural design and integration of biomaterials, cells and bioactive molecules to fabricate implantable materials to which tissue cells can adhere and proliferate. Polyurethanes, 176 poly(glycerol sebacate), 282 polycitrate, 283,284 polycaprolactone, 285 and LCE 286 have shown extremely strong potential for tissue repair applications.…”

Section: Structures and Processing Advantages Of Elastomers For Tissu...mentioning

confidence: 99%

Degradable biomedical elastomers: paving the future of tissue repair and regenerative medicine

Jia,

Huang,

Dong

et al. 2024

Chem. Soc. Rev.

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Section: Structures and Processing Advantages Of Elastomers For Tissu...mentioning

confidence: 99%

Degradable biomedical elastomers: paving the future of tissue repair and regenerative medicine

Jia,

Huang,

Dong

et al. 2024

Chem. Soc. Rev.

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“…Nevertheless, the surface properties of the polymers are frequently critical, necessitating the meticulous identification and acquisition of these characteristics. Non-thermal plasma exposure is commonly used to alter the surface characteristics of polymers [1][2][3][4][5][6][7][8][9], even for biofunctionalizing 3D-printed structures [10].…”

Section: Introductionmentioning

confidence: 99%

Effects of Atmospheric Pressure Plasma Jet on 3D-Printed Acrylonitrile Butadiene Styrene (ABS)

Nastuta,

Asandulesa,

Spiridon

et al. 2024

Materials

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Polymers are essential in several sectors, yet some applications necessitate surface modification. One practical and eco-friendly option is non-thermal plasma exposure. The present research endeavors to examine the impacts of dielectric barrier discharge atmospheric pressure plasma on the chemical composition and wettability properties of acrylonitrile butadiene styrene surfaces subject to the action of additive manufacturing. The plasma source was produced by igniting either helium or argon and then adjusted to maximize the operational conditions for exposing polymers. The drop in contact angle and the improvement in wettability after plasma exposure can be due to the increased oxygen-containing groups onto the surface, together with a reduction in carbon content. The research findings indicated that plasma treatment significantly improved the wettability of the polymer surface, with an increase of up to 60% for both working gases, while the polar index increased from 0.01 up to 0.99 after plasma treatment. XPS measurements showed an increase of up to 10% in oxygen groups at the surface of He–plasma-treated samples and up to 13% after Ar–plasma treatment. Significant modifications were observed in the structure that led to a reduction of its roughness by 50% and also caused a leveling effect after plasma treatment. A slight decrease in the glass and melting temperature after plasma treatment was pointed out by differential scanning calorimetry and broadband dielectric spectroscopy. Up to a 15% crystallinity index was determined after plasma treatment, and the 3D printing process was measured through X-ray diffraction. The empirical findings encourage the implementation of atmospheric pressure plasma-based techniques for the environmentally sustainable manipulation of polymers for applications necessitating higher levels of adhesion and specific prerequisites.

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“…In contrast, methods for covalent linkage to an implant surface allow for sustained biological activity. [17][18][19][20][21][22] Covalent attachment of bioactive molecules on surfaces has been traditionally achieved using methods relying on wetchemical steps. [16] Examples of these approaches include linker chemistry methods based on salinization, [23] PEGylation, [24] and heparinization.…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, methods for covalent linkage to an implant surface allow for sustained biological activity. [ 17–22 ]…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Plasma Polymer Coatings on 3D Materials for Orthopedic Applications

Dao,

Gaitanos,

Kamble

et al. 2023

Adv Materials Inter

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Covalent biofunctionalization of implant surfaces using anti microbial agents is a promising approach to reducing bone infection and implant failure. Radical‐rich, ion‐assisted plasma polymerized (IPP) coatings enable surface covalent biofunctionalization in a simple manner; but until now, they are limited to only 2D surfaces. Here a new technology is demonstrated to create homogenous IPP coatings on 3D materials using a rotating, conductive cage that is negatively biased while immersed in RF plasma. Evidence is provided that under controlled energetic ion bombardment, this technology enables the formation of highly robust and homogenous radical‐rich coatings on 3D objects for subsequent covalent attachment of antimicrobial agents. To functionally apply this technology, the broad‐spectrum antimicrobial CSA‐90 is attached to the surfaces, where it retained potent antibacterial activity against Staphylococcus aureus. CSA‐90 covalent functionalization of stainless‐steel pins used in a murine model of orthopedic infection revealed the highly promising potential of this coating system to reduce S. aureus infection‐related bone loss. This study takes the previous research on plasma‐based covalent functionalization of 2D surfaces a step further, with important implications for ushering in a new dimension in the biofunctionalization of 3D structures for applications in bone implants and beyond.

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Biofunctionalized 3D printed structures for biomedical applications: A critical review of recent advances and future prospects

Cited by 20 publications

References 337 publications

Degradable biomedical elastomers: paving the future of tissue repair and regenerative medicine

Degradable biomedical elastomers: paving the future of tissue repair and regenerative medicine

Effects of Atmospheric Pressure Plasma Jet on 3D-Printed Acrylonitrile Butadiene Styrene (ABS)

Antibacterial Plasma Polymer Coatings on 3D Materials for Orthopedic Applications

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