Biofunctionalized nanostructured tungsten trioxide based sensor for cardiac biomarker detection

Sandil, Deepika; Kumar, Saurabh; Arora, Kamal; Srivastava, Saurabh; Malhotra, Bansi D.; Sharma, Suresh C.; Puri, Nitin K.

doi:10.1016/j.matlet.2016.09.107

Cited by 26 publications

(4 citation statements)

References 11 publications

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“…For example, Ahammad et al [49] described the electrodeposition of gold nanoparticles on indium tin oxide (ITO) electrodes and used these electrodes to detect cTnI by measuring open-circuit potential (OCP) values; they observed a linear dependence between OCP changes and cTnI levels over a range of concentrations from 1 to 100 ng/mL. In another study, Sandil et al [50] studied the deposition of 3-aminopropyltriethoxysilane (APTES)-functionalized GQDs offer a wide range of advantages over other materials for the sensing of AMI, including the formation of strong interactions between cTnI and GQDs. In addition, graphene-modified electrodes exhibit excellent electrochemical responses due to the conductive nature of graphene and low levels of biomarker consumption; moreover, the reusability of the electrodes allows for several readings even after introducing new solutions [47].…”

Section: Gqds-based Electrochemical Biosensing For Early Diagnosis Of...mentioning

confidence: 99%

“…For example, Ahammad et al [ 49 ] described the electrodeposition of gold nanoparticles on indium tin oxide (ITO) electrodes and used these electrodes to detect cTnI by measuring open-circuit potential (OCP) values; they observed a linear dependence between OCP changes and cTnI levels over a range of concentrations from 1 to 100 ng/mL. In another study, Sandil et al [ 50 ] studied the deposition of 3-aminopropyltriethoxysilane (APTES)-functionalized tungsten trioxide nanosheets on ITO electrodes via an electrophoretic deposition approach; they immobilized cardiac troponin I antibodies (anti-cTnI) on these structures. The structures enabled the detection of cTnI with a linear detection range of 0.1 to 100 ng mL −1 ; stability up to 6 weeks was observed.…”

Section: Gqds-based Electrochemical Biosensing For Early Diagnosis Of...mentioning

confidence: 99%

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Graphene Quantum Dots-Based Electrochemical Biosensing Platform for Early Detection of Acute Myocardial Infarction

et al. 2022

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Heart failure resulting from acute myocardial infarction (AMI) is an important global health problem. Treatments of heart failure and AMI have improved significantly over the past two decades; however, the available diagnostic tests only give limited insights into these heterogeneous conditions at a reversible stage and are not precise enough to evaluate the status of the tissue at high risk. Innovative diagnostic tools for more accurate, more reliable, and early diagnosis of AMI are urgently needed. A promising solution is the timely identification of prognostic biomarkers, which is crucial for patients with AMI, as myocardial dysfunction and infarction lead to more severe and irreversible changes in the cardiovascular system over time. The currently available biomarkers for AMI detection include cardiac troponin I (cTnI), cardiac troponin T (cTnT), myoglobin, lactate dehydrogenase, C-reactive protein, and creatine kinase and myoglobin. Most recently, electrochemical biosensing technologies coupled with graphene quantum dots (GQDs) have emerged as a promising platform for the identification of troponin and myoglobin. The results suggest that GQDs-integrated electrochemical biosensors can provide useful prognostic information about AMI at an early, reversible, and potentially curable stage. GQDs offer several advantages over other nanomaterials that are used for the electrochemical detection of AMI such as strong interactions between cTnI and GQDs, low biomarker consumption, and reusability of the electrode; graphene-modified electrodes demonstrate excellent electrochemical responses due to the conductive nature of graphene and other features of GQDs (e.g., high specific surface area, π–π interactions with the analyte, facile electron-transfer mechanisms, size-dependent optical features, interplay between bandgap and photoluminescence, electrochemical luminescence emission capability, biocompatibility, and ease of functionalization). Other advantages include the presence of functional groups such as hydroxyl, carboxyl, carbonyl, and epoxide groups, which enhance the solubility and dispersibility of GQDs in a wide variety of solvents and biological media. In this perspective article, we consider the emerging knowledge regarding the early detection of AMI using GQDs-based electrochemical sensors and address the potential role of this sensing technology which might lead to more efficient care of patients with AMI.

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Section: Gqds-based Electrochemical Biosensing For Early Diagnosis Of...mentioning

confidence: 99%

“…For example, Ahammad et al [ 49 ] described the electrodeposition of gold nanoparticles on indium tin oxide (ITO) electrodes and used these electrodes to detect cTnI by measuring open-circuit potential (OCP) values; they observed a linear dependence between OCP changes and cTnI levels over a range of concentrations from 1 to 100 ng/mL. In another study, Sandil et al [ 50 ] studied the deposition of 3-aminopropyltriethoxysilane (APTES)-functionalized tungsten trioxide nanosheets on ITO electrodes via an electrophoretic deposition approach; they immobilized cardiac troponin I antibodies (anti-cTnI) on these structures. The structures enabled the detection of cTnI with a linear detection range of 0.1 to 100 ng mL −1 ; stability up to 6 weeks was observed.…”

Section: Gqds-based Electrochemical Biosensing For Early Diagnosis Of...mentioning

confidence: 99%

Graphene Quantum Dots-Based Electrochemical Biosensing Platform for Early Detection of Acute Myocardial Infarction

et al. 2022

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“…The immunosensor was employed for CEA determination in human serum samples. Furthermore, a WO 3 -RGO NC-based EC immunosensor was testified for the cardiac troponin-I (cTnI) biomarker detection [ 193 ]. A modified anti-cTnI/APTES/WO 3 -RGO/ITO sensor was attained via electrophoretic deposition method, trailed by covalent immobilization cTnI-Ab.…”

Section: Gr-based Ec Sensors For Bioanalytes Detectionmentioning

confidence: 99%

The Roadmap of Graphene-Based Sensors: Electrochemical Methods for Bioanalytical Applications

et al. 2022

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Graphene (GR) has engrossed immense research attention as an emerging carbon material owing to its enthralling electrochemical (EC) and physical properties. Herein, we debate the role of GR-based nanomaterials (NMs) in refining EC sensing performance toward bioanalytes detection. Following the introduction, we briefly discuss the GR fabrication, properties, application as electrode materials, the principle of EC sensing system, and the importance of bioanalytes detection in early disease diagnosis. Along with the brief description of GR-derivatives, simulation, and doping, classification of GR-based EC sensors such as cancer biomarkers, neurotransmitters, DNA sensors, immunosensors, and various other bioanalytes detection is provided. The working mechanism of topical GR-based EC sensors, advantages, and real-time analysis of these along with details of analytical merit of figures for EC sensors are discussed. Last, we have concluded the review by providing some suggestions to overcome the existing downsides of GR-based sensors and future outlook. The advancement of electrochemistry, nanotechnology, and point-of-care (POC) devices could offer the next generation of precise, sensitive, and reliable EC sensors.

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“…While EIS sensors stand-out due to their performance, there were issues with the reported biosensors. [1] These included, but not limited to decreased specificity in serum [4], sample processing requirements [5] and performance decrease after storage [6]. This is due to most EIS biosensors using two or three electrodes which requires a redox solution for measurement.…”

Section: Introductionmentioning

confidence: 99%

Development of a Biosensor for fast point-of-care Blood Analysis of Troponin

Bayford

Damaso

Jiang

et al. 2022

2022 44th Annual International Conference of the IEEE Engineering in Medicine &Amp; Biology Society (EMBC)

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Biofunctionalized nanostructured tungsten trioxide based sensor for cardiac biomarker detection

Cited by 26 publications

References 11 publications

Graphene Quantum Dots-Based Electrochemical Biosensing Platform for Early Detection of Acute Myocardial Infarction

Graphene Quantum Dots-Based Electrochemical Biosensing Platform for Early Detection of Acute Myocardial Infarction

The Roadmap of Graphene-Based Sensors: Electrochemical Methods for Bioanalytical Applications

Development of a Biosensor for fast point-of-care Blood Analysis of Troponin

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