Biogas technology has the potential to provide benefits to three priority areas in Sub-Saharan Africa (SSA): energy supply, sanitation, and food security. Despite this, uptake of biogas systems has been slow and sporadic in the region. This review paper investigates what has prevented widespread dissemination of the technology in SSA by looking at the key barriers in the region, as well as identifying the main opportunities and the lessons that can be learned from successful biogas dissemination experiences in Rwanda, Tanzania, China, India, and Nepal. Installation costs, limited awareness and training for biogas users and insufficient follow-up services were recognised as being among the key barriers. SSA has favourable conditions for biogas technology, namely a suitable tropical climate in most parts of the region, a dominance of agricultural activities, and interest in alternatives to expensive conventional energy services. The region's favourable conditions therefore provide opportunities for increasing uptake of the technology. Experiences in other regions highlighted the importance of the government in supporting the biogas sector through suitable policies and incentives. Collaboration between research institutions, governmental departments, and biogas users, both current and future, was also recognised as being vital to improve the technology's dissemination and appropriate, long-term use.