Biogenic Nanoparticles as Theranostic Agents: Prospects and Challenges

Raghuwanshi, Navdeep; Srivastava, Amit Kumar; Yadav, Tara Chand; Gupta, Sonam; Khatri, Kapil; Pruthi, Vikas

doi:10.1002/9781119509868.ch19

Cited by 3 publications

(1 citation statement)

References 113 publications

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“…Inorganic nanoparticles include metal and metal-oxide-based nanomaterials that can be synthesized using constructive or destructive methods [9]. The most common metals used in the synthesis of nanomaterials are iron (Fe), zinc (Zn), silver (Ag), aluminum (Al), cadmium (Cd), copper (Cu), cobalt (Co), gold (Au) and lead (Pb) [10]. Metal oxide nanoparticles are used to improve the characteristics of metal nanomaterials.…”

Section: Introductionmentioning

confidence: 99%

Facile Green Synthesis of Zinc Oxide Nanoparticles with Potential Synergistic Activity with Common Antifungal Agents against Multidrug-Resistant Candidal Strains

et al. 2022

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The high incidence of fungal resistance to antifungal drugs represents a global concern, contributing to high levels of morbidity and mortality, especially among immunocompromised patients. Moreover, conventional antifungal medications have poor therapeutic outcomes, as well as possible toxicities resulting from long-term administration. Accordingly, the aim of the present study was to investigate the antifungal effectiveness of biogenic zinc oxide nanoparticles (ZnO NPs) against multidrug-resistant candidal strains. Biogenic ZnO NPs were characterized using physicochemical methods, such as UV-vis spectroscopy, transmission electron microscopy (TEM), energy-dispersive X ray (EDX) spectroscopy, FTIR (Fourier transform infrared) spectroscopy and X-ray powder diffraction (XRD) analysis. UV spectral analysis revealed the formation of two absorption peaks at 367 and 506 nm, which preliminarily indicated the successful synthesis of ZnO NPs, whereas TEM analysis showed that ZnO NPs exhibited an average particle size of 22.84 nm. The EDX spectrum confirmed the successful synthesis of ZnO nanoparticles free of impurities. The FTIR spectrum of the biosynthesized ZnO NPs showed different absorption peaks at 3427.99, 1707.86, 1621.50, 1424.16, 1325.22, 1224.67, 1178.22, 1067.69, 861.22, 752.97 and 574.11 cm−1, corresponding to various functional groups. The average zeta potential value of the ZnO NPs was −7.45 mV. XRD analysis revealed the presence of six diffraction peaks at 2θ = 31.94, 34.66, 36.42, 56.42, 69.54 and 76.94°. The biogenic ZnO NPs (100µg/disk) exhibited potent antifungal activity against C. albicans, C. glabrata and C. tropicalis strains, with suppressive zone diameters of 24.18 ± 0.32, 20.17 ± 0.56 and 26.35 ± 0.16 mm, respectively. The minimal inhibitory concentration (MIC) of ZnO NPs against C. tropicalis strain was found to be 10 μg/mL, whereas the minimal fungicidal concentration (MFC) was found to be 20 μg/mL. Moreover, ZnO NPs revealed a potential synergistic efficiency with fluconazole, nystatin and clotrimazole antifungal drugs against C. albicans strain, whereas terbinafine, nystatin and itraconazole antifungal drugs showed a potential synergism with ZnO NPs against C. glabrata as a multidrug-resistant strain. In conclusion, pomegranate peel extract mediated green synthesis of ZnO NPs with potential physicochemical features and antimicrobial activity. The biosynthesized ZnO NPs could be utilized for formulation of novel drug combinations to boost the antifungal efficiency of commonly used antifungal agents.

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Section: Introductionmentioning

confidence: 99%

Facile Green Synthesis of Zinc Oxide Nanoparticles with Potential Synergistic Activity with Common Antifungal Agents against Multidrug-Resistant Candidal Strains

et al. 2022

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Can bilirubin nanomedicine become a hope for the management of COVID-19?

et al. 2021

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Bilirubin has been proven to possess significant anti-inflammatory, antioxidant and antiviral activities. Recently, it has been postulated as a metabolic hormone. Further, moderately higher bilirubin levels are positively associated with reduced risk of cardiovascular disease, diabetes, metabolic syndrome and obesity. However, due to poor solubility the therapeutic delivery of bilirubin remains a challenge. Nanotechnology offers unique advantages which may be exploited for improved delivery of bilirubin to the target organ with reduced risk of systemic toxicity. Herein, we postulate the use of intravenous or inhalation of bilirubin nanomedicine to combat systemic dysfunction associated with COVID-19 owing to the remarkable preclinical efficacy and optimistic results of various clinical studies of bilirubin in non-communicable disorders. Bilirubin nanomedicine may be used to harness the proven preclinical efficacy against COVID-19 related systemic complications.

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Applications of Metal and Metal Oxide-Based Nanomaterials in Medical and Biological Activities

Ashajyothi

Handral

Prabhurajeshwar

2022

Handbook of Research on Green Synthesis and Applications of Nanomaterials

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Nanomaterials have been attracting the attention of many researchers because of their size, high stability, affinity, and selectivity nature. Over the past decades, considerable intensive studies on many metal and metal-oxide nanomaterials have drawn consideration through their significant properties like size, shape, surface mass proportion, and their reactivity; all these properties are fundamental cornerstones for the turn of events and use of nanomaterials and nanoscale gadgets in biomedical areas. There is also a vast scope for a broad range of biofunctional applications such as antibacterial, antiviral, antifungal, antitumor, bioimaging, tissue engineering, biosensors, gene, and drug delivery. The authors review the nature, forms, and synthesis of nanomaterials here, with a thorough biological synthesis assessment. They also address the development of nanoparticles by microorganisms in depth, and this chapter also includes updates on different biological and biomedical applications of these bionanomaterials.

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Biogenic Nanoparticles as Theranostic Agents: Prospects and Challenges

Cited by 3 publications

References 113 publications

Facile Green Synthesis of Zinc Oxide Nanoparticles with Potential Synergistic Activity with Common Antifungal Agents against Multidrug-Resistant Candidal Strains

Facile Green Synthesis of Zinc Oxide Nanoparticles with Potential Synergistic Activity with Common Antifungal Agents against Multidrug-Resistant Candidal Strains

Can bilirubin nanomedicine become a hope for the management of COVID-19?

Applications of Metal and Metal Oxide-Based Nanomaterials in Medical and Biological Activities

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