Biogenic Nanosilver against Multidrug-Resistant Bacteria (MDRB)

Barros, Caio; Fulaz, Stephanie; Stanisić, Danijela; Tasić, Ljubica

doi:10.3390/antibiotics7030069

Cited by 106 publications

(71 citation statements)

References 157 publications

(127 reference statements)

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“…Further, the copolymer biomaterials synthesized with high antibacterial activity against E. coli and S. aureus. These all reports concluded that the biogenic silver nanoparticles are used in combat against multidrug resistant bacterial infection [29].…”

Section: Application In Multi-drug Resistant Therapymentioning

confidence: 99%

Toxicity and application of nano-silver in multi-drug resistant therapy

2020

Lett Appl NanoBioSci

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Nano-silver toxicity is a major challenge in the field of nanotechnology and nanoscience. Silver nanoparticles have antibacterial activity against gram-negative and gram-positive bacteria. The level of nanotoxicity varies according to the size, shape, surface charge and cellular uptake. The size of nanoparticles influences their interaction and reactivity with cell membranes. Silver nanoparticles were investigated for the broad-spectrum antibacterial activities, especially against antibiotic-resistant bacteria. In the present scenario, pharmaceutical and biomedical sectors are facing the challenges of the continuous increase in multidrug-resistant human pathogenic microbes. The development of multidrug resistance has become a global issue with serious consequences in the management of infectious diseases caused by pathogenic bacteria. For the multi-drug resistant therapy, various combinations of antibiotics were used with silver nanoparticles. This review discusses the nanotoxicity and bactericidal potential of silver nanoparticles against the multi-drug resistant bacteria.

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Section: Application In Multi-drug Resistant Therapymentioning

confidence: 99%

Toxicity and application of nano-silver in multi-drug resistant therapy

2020

Lett Appl NanoBioSci

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“…A convenient and practical approach where the nutritional quality, sensorial properties, color, and shelf life of the grains remain unchanged is warranted in curbing this menace. Therefore, we propose nanoparticles as the ultimate solution to the predicament mentioned above since they are known to exert potent biocidal activities against the vast myriad of microorganisms [7][8][9][10][11][12][13][14][15][16][17] involves in contaminating grains, hence could be utilized as antifungal agents during grain storage.…”

Section: Introductionmentioning

confidence: 99%

The Potential Application of Nanoparticles on Grains during Storage: Part 1 – An Overview of Inhibition against Fungi and Mycotoxin Biosynthesis

Nsengumuremyi¹,

Adadi²,

Oppong³

et al. 2020

Mycotoxins and Food Safety

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Cereals and legumes are the major staples across the globe, thus providing nutrition to humans, and their by-products utilized as animal feeds. However, mycotoxins synthesized by fungi contaminate these grains on the field during cultivation and are transferred to the storage centers. These fungi infect and deteriorate stored grains, thereby tampering with food security. Moreover, the deterioration decreases nutrient content and alters the physicochemical properties of grains. The current conventional methods used to reduce grain contamination are becoming ineffecitive, coupled with the detrimental health effects it has on the consumer and to the environment. Herein, we present an overview of the use of nanoparticles (NPs) as an alternative and novel method of reducing mycotoxin biosynthesis due to their potent biocidal properties. Silver nanoparticles (AgNPs) are considered and have shown promising and effective fungicidal properties against important storage fungi, and pests hence could be utilized in the agriculture and food sector for a vast myriad of applications. These may help to either minimize/eradicate the exposure to the mycotoxins and its adverse health effects, hence contributing to the holistic growth and development of people.

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“…The biosynthesis of metallic nanoparticles has been described in a range of organisms spanning plants, fungi, and bacteria, often through metal-toxicity resistance mechanisms. (16)(17)(18)(19) Whilst the processes for many of these remain poorly understood, they hold great potential for more environmentally friendly and up-scalable production of AgNP than chemical synthesis.…”

Section: Introductionmentioning

confidence: 99%

“…A number of review articles have been authored which give useful overviews of bacteriogenic metallic nanoparticle synthesis. (14,15,(17)(18)(19)(20)(21)(22) However, to date, no in-depth summary of findings has been published relating to the reaction conditions under which AgNPs are synthesised and the impact that these conditions have on the products. Therefore, this article aims to bring together such results and discuss how biosynthetic reaction parameters can be used to optimise AgNP production with a focus on shape and size control.…”

Section: Introductionmentioning

confidence: 99%

Bacteria and nanosilver: the quest for optimal production

Mabey

Cristaldi

Oyston

et al. 2019

Critical Reviews in Biotechnology

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Silver nanoparticles (AgNPs) have potential uses in many applications, but current chemical production methods are challenged by scalability, limited particle stability, and the use of hazardous chemicals. The biological processes present in bacteria to mitigate metallic contaminants in their environment present a potential solution to these challenges. Before commercial exploitation of this technology can be achieved, the quality of bacteriogenic AgNPs needs to be improved for certain applications. While the colloidal and morphological stabilities of biogenic AgNPs are widely regarded as superior to chemogenic particles, little control over the synthesis of particle morphologies has been achieved in biological systems. This article reviews a range of biosynthetic reaction conditions and how they affect AgNP formation in bacteria to understand which are most influential. While there remains uncertainty, some general trends are emerging: higher Ag + concentrations result in higher AgNP production, up to a point at which the toxic effects begin to dominate; the optimal temperature appears to be heavily species-dependent and linked to the optimal growth temperature of the organism. However, hotter conditions generally favour higher production rates, while colder environments typically give greater shape diversity. Little attention has been paid to other potentially important growth conditions including halide concentrations, oxygen exposure, and irradiation with light. To fully exploit biosynthetic production routes as alternatives to chemical methods, hurdles remain with controlling particle morphologies and require further work to elucidate and harness. By better understanding the factors influencing AgNP production a foundation can be laid from which shape-controlled production can be achieved.

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Biogenic Nanosilver against Multidrug-Resistant Bacteria (MDRB)

Cited by 106 publications

References 157 publications

Toxicity and application of nano-silver in multi-drug resistant therapy

Toxicity and application of nano-silver in multi-drug resistant therapy

The Potential Application of Nanoparticles on Grains during Storage: Part 1 – An Overview of Inhibition against Fungi and Mycotoxin Biosynthesis

Bacteria and nanosilver: the quest for optimal production

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