Biogenic selenium and its hepatoprotective activity

Abstract

Elemental selenium nanoparticles (SeNPs) have multiple biological activities. In this study, we investigated the protective effects of biogenic SeNPs (BioSeNPs) on CCl4-induced liver damage in mice. The results showed that: (i) when compared to sodium selenite (SS), BioSeNPs has a similar tissue distribution after intragastrical administration to mice; (ii) BioSeNPs and SS showed comparable efficacy in increasing the activities of glutathione peroxidase and thioredoxin reductase in liver cell lines, mice blood and liver; (iii) pretreatment with BioSeNPs inhibiting the elevation of activities of various enzymes significantly which included aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase and liver lipid peroxide (p < 0.05 or p < 0.01) in CCl4-treated mice; (iv) activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) were significantly increased (p < 0.05 or p < 0.01) after a pretreatment with BioSeNPs in CCl4-treated mice; (v) histopathological damages in the liver from CCl4-treated mice were ameliorated by a pretreatment with BioSeNPs. In conclusion, these results have shown that BioSeNPs is able to protect the liver from CCl4-induced hepatic damage via increasing the antioxidant capacity and inhibiting oxidative damage. BioSeNPs may have the potential to be used as a trace element food supplement inducing antioxidant bioactivities.

Antioxidant Capacity and Hepatoprotective Role of Chitosan-Stabilized Selenium Nanoparticles in Concanavalin A-Induced Liver Injury in Mice

“…As presented in Figure 6, the serum and hepatic Se levels in the Se-supplementation groups were significantly higher than those of other groups (p < 0.05), indicating that CS-SeNPs might enhance the Se stock in the animals. This is in line with the reported efficient Se-retention capacity of some SeNPs stabilized by other macro-molecules [2,3,25,40] or microorganisms [17], confirming the potential of nanoparticles in Se supplementation. Se retention by extra Se supplementation needs to be discussed.…”

“…The third point is the broad hepatoprotection of SeNPs. It was reported that SeNPs alone or combined with vitamins might protect animals from the hepatic injury caused by toxic chemicals (e.g, carbon tetrachloride [17], acetaminophen [18], and acrylamide [19]) or by pathogen infections (e.g, Schistosoma spp. [20]).…”

Effects of Sub-Lethal Doses of Selenium Nanoparticles on the Health Status of Rats

“…In our study, toxic effects on liver tissue at the biochemical level were not observed. Similar results were reported by Li et al [35]. Compared to sodium selenite, biogenic SeNPs showed a protective effect on liver parenchyma and inhibiting effect for the elevation of the level of liver enzymes in carbon tetrachloride-induced liver damage in mice.…”

Biochemical alterations in diclofenac-treated rats: Effect of selenium on oxidative stress, inflammation, and hematological changes

“…Conversely, rats co-treated with Sel demonstrably ameliorate DCF-induced hepatic injury dose-dependently, evaluated by transaminases levels in serum. 48,49 Renal function marker enzymes such as urea and creatinine are metabolic waste products primarily excreted in the urine. They are important in the diagnosis of kidney injury.…”

“…Conversely, rats co-treated with Sel demonstrably ameliorate DCF-induced hepatic injury dose-dependently, evaluated by transaminases levels in serum. 48,49…”