Biogenic synthesis by Gracilaria corticata for efficient production of biocompatible silver nanoparticles and its applications

Abstract

Biosynthesis of silver nanoparticles (AgNPs) from seaweed extracts is currently under exploitation. Seaweed extracts are cost effective and eco-friendly and thus can be an economic and efficient alternative for large-scale synthesis of nanoparticles. The present study reports the synthesis of AgNPs from silver precursor, silver nitrate using aqueous extract of seaweed Gracilaria corticata (G. corticata). The organic compounds present in the filtrate of G. corticata were mainly responsible for reduction of silver ions to AgNPs. The filtrate when added to 1 mM aqueous silver nitrate solution at 121°C changed to dark brown colour solution within ten minutes, which confirms the bioreduction. These extremely stable AgNPs were characterised by UV-Vis spectrophotometer, FTIR, XRD, TEM, and EDS analysis. The nanoparticles exhibited maximum absorbance at 424 nm in the UV spectrum. The presence of proteins was identified by FTIR. TEM micrograph revealed the formation of polydispersed and spherical shaped nanoparticles with the size range of 10-50 nm and the presence of elemental silver were confirmed by EDS analysis. These nanoparticles showed cytotoxic activity against Hep2 cells. She has a wealth of knowledge in marine biotechnology and implements the same in student projects. She is an effective research guide with an ability to understand the diversified capabilities of research students in addition to reviewing and selecting new areas of research with focus on qualitative and quantitative results that will help the society.

Biogenic synthesis of copper oxide nanoparticles using leaf extracts of Cissus quadrangularis and Piper betle and its antibacterial effects

“…The band at 1626 cm −1 , 1622 cm −1 represents the C-O stretching of the COOH group. The existence of band at 536 and 612 cm −1 are recognized to be the vibrations of Cu-O, confirming the formation of copper oxide nanoparticles [33,34]. The above-mentioned results confirm the existence of phytochemicals such as alkaloids, flavonoids, tannins, proteins, and carboxylic acids which were responsible for the bioreduction and stabilization of copper oxide nanoparticles.…”

Bionanofactories for Green Synthesis of Silver Nanoparticles: Toward Antimicrobial Applications

“…It is, thus, evident that the synergy of AgNPs with antibiotics has appreciable antimicrobial effects, which hinders the development of resistance and improves the antimicrobial properties of the antibiotics, while also decreasing their dosage [ 44 ]. In addition to their antibacterial activity, the cytotoxic activity of AgNPs on Hep2 cell lines was also studied using the method of Daikoku et al (1989); moreover, on similar lines, [ 40 ] first reported the cytotoxic activity of AgNPs synthesized using seaweed extracts of G. corticate . Moreover, nanoparticles are well known for their target specificity.…”

Hydrothermal preparation of TiO2-Ag nanoparticles and its antimicrobial performance against human pathogenic microbial cells in water

“…Silver is a metal that could be biologically, physically or chemically transferred into silver nanoparticles and used as a powerful antimicrobial agent, for the treatment of diseases for which microbes are responsible (Devi and Bhimba, 2013;Abu-Saied et al, 2014;2018), because of its low toxicity on mammalian cells and tissues (Simonetti et al, 1992;Ahearn et al, 1995).…”