Biohybrid based on layered terbium hydroxide and applications as drug carrier and biological fluorescence probe

Abstract

Aspirin (abbr. ASA) is intercalated into the layered terbium hydroxide (LTbH) by anion exchange method. Structure, chemical compositions, thermostability, morphology, luminescence property, cytotoxic effects and controlled-release behaviors have been investigated. The ASA molecules may embed between layers with monolayered vertical arrangement, and the thermal stability of organics was enhanced after intercalation. The Tb 3+ luminescence in ASA-LTbH composites was enhanced compared with LTbH precusor and the luminescence intensity increased with the deprotonation degree. The cytotoxic effect of LTbH was observed with a sulforhodamine B (SRB) colorimetric assay, which revealed that the LTbH showed low cytotoxic effects. In addition, the ASA-LTbH composites exhibited a sustained release of ASA in Na 2 HPO 4 -NaH 2 PO 4 buffer solution at pH 6.86 and 37°C. Construction of LRHs composites with drug molecules provided a beneficial pathway for preparing biohybrid based on LRHs, which may have potential applications in drug delivery carrier and biological fluorescence probe.

Layered terbium hydroxides for simultaneous drug delivery and imaging

“…62 Further work by this group developed LEuH intercalated with naproxen (nap), and LTbH intercalated with aspirin, diclofenac, and indomethacin (asa, dic, and imc). [63][64][65] It was demonstrated that LEuH-nap and the LTbH-drug intercalates have high biocompatibility (>80%) in multiple human cancer cell lines at concentrations up to 100 µg ml −1 . The majority of drug was released from LEuH-nap and LTbH-asa in the first 3 hours, 63,64 whereas LTbH-dic and LTbH-imc showed sustained release over 25 h. 65 It was found also that LEuH and LTbH showed vastly increased luminescence intensities after intercalation with nap and asa respectively, owing to efficient energy transfer between the host and guest species.…”

Layered gadolinium hydroxides for simultaneous drug delivery and imaging

“…57 More recently, Gu and co-workers generated a naproxen-intercalated layered europium hydroxide, which was found to release the incorporated drug over about 200 min, retain the inherent luminescence of Eu 3+ , and to be highly biocompatible. 58 Finally, Ju and Gu have reported an aspirin intercalate of a layered terbium hydroxide formed by ion exchange, and observed enhanced Tb luminescence intensity and sustained drug release over 10 h. 59 Therefore, it appears that LRH-drug composites have great promise, but more work is required to explore this in detail.…”

The first amorphous and crystalline yttrium lactate: synthesis and structural features

“…[61][62][63] These ion-exchangeable and exfoliatable substances have a great deal of exibility in terms of their chemical composition 61,[64][65][66] and are now regarded as a basis for promising bioactive theranostic materials. 67,68 From the ndings of the current study, a paper-like material couldn't be classied as a layered rare earth hydroxide as the positions of the maxima in its diffraction pattern (see Fig. 2) are incompatible with the LRHs' structure.…”