Biohybrid nanogels

Abstract

Biohybrid nanogels are crosslinked colloidal networks that consist of biological and synthetic polymers as building blocks. Such polymer colloidal particles attracted much attention in recent years mainly due to their outstanding properties and huge application potential that by far overcome classical nanogels or microgels prepared from water-soluble synthetic polymers. In this report, we review recent developments on the synthesis and properties of biohybrid nanogels.

Structural and interaction parameters of thermosensitive native α-elastin biohybrid microgel

“…[12]). The synthetic part of the microgel may comprise synthetic macromolecules that are integrated by physical entanglements or covalent bonds and contribute mainly to the enhancement of mechanical properties and stabilization of microgels in the aqueous phase.…”

Formation of iron oxide nanoparticle-loaded γ-polyglutamic acid nanogels for MR imaging of tumors

“…As a powerful noninvasive imaging modality, magnetic resonance (MR) imaging has attracted substantial attention in the early detection and diagnosis of cancer or other diseases due to its 25 high spatial resolution, superior soft tissue contrast, multidimensional imaging, and lack of radiological consequences. [1][2][3][4] To further improve the imaging quality and sensitivity, a wide variety of MR contrast agents, such as superparamagnetic iron oxide nanoparticles (Fe 3 O 4 NPs), 5-7 manganese oxide NPs 8 and 30 gadolinium chelates 9 have been developed.…”

Stimuli-Sensitive Microgels from Native Elastin: An Easy Approach for a Drug Release System

“…Regarding the fact that the dextran did not participate in the crosslinking reaction but serves just as another component in the solvent, it appears unsurprising that the particle sizes came out similar to those prepared without dextran (see Table 1). Figure 7 depicts Loading is expressed both as milligrams and relative to the weight of elastin (wt%) 2 Uptake expresses both as millograms and percentage relative to the loading (wt%) the cumulative release curves for the two different crosslinking densities and at the two temperatures. Release was slower for the more densely crosslinked BS3-elastin microgels than for the hydrophilic PEG-DGE crosslinked gels.…”

“…Covalently crosslinked hydrogel particles of size in the nanometer to micrometer range (i.e., microgels), have found increasing interest for controlled and targeted drug delivery [1][2][3]. These particles are soft colloids that are swollen by the aqueous medium in which they are dispersed.…”