Bioidentical Progesterone Cream for Menopause-Related Vasomotor Symptoms: Is it Effective?

Whelan, Anne Marie; Jurgens, Tannis; Trinacty, Melanie

doi:10.1345/aph.1r362

Cited by 14 publications

(14 citation statements)

References 24 publications

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“…Custom compounded bioidentical hormones are not recommended because data supporting claims that they are safer and more effective than standard hormones are lacking. 117,118 Young cancer survivors experiencing menopause at an early age can consider oral contraceptives or MHT for symptom relief and potential cardiac and bone benefits as long as not contraindicated.…”

Section: Menopausementioning

confidence: 99%

“…In one study of breast cancer survivors, the control group used a nonhormonal moisturizer and saw a transient improvement in vaginal symptoms. 118 Topical anesthetics may help with vaginal pain as demonstrated in a study of 46 breast cancer survivors that found that application of lidocaine to the vulvar vestibule before vaginal penetration improved dyspareunia. 208 …”

Section: Sexual Dysfunctionmentioning

confidence: 99%

See 1 more Smart Citation

Survivorship, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology

Denlinger¹,

Sanft²,

Baker³

et al. 2017

J Natl Compr Canc Netw

106

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Many cancer survivors experience menopausal symptoms, including female survivors taking aromatase inhibitors or with a history of oophorectomy or chemotherapy, and male survivors who received or are receiving androgen-ablative therapies. Sexual dysfunction is also common in cancer survivors. Sexual dysfunction and menopause-related symptoms can increase distress and have a significant negative impact on quality of life. This portion of the NCCN Guidelines for Survivorship provide recommendations for screening, evaluation, and treatment of sexual dysfunction and menopausal symptoms to help healthcare professionals who work with survivors of adult-onset cancer in the posttreatment period.

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Section: Menopausementioning

confidence: 99%

Section: Sexual Dysfunctionmentioning

confidence: 99%

Survivorship, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology

Denlinger¹,

Sanft²,

Baker³

et al. 2017

J Natl Compr Canc Netw

106

View full text Add to dashboard Cite

show abstract

“…Krem formuyla yapılmış 4 randomize kontrollü çalışmada, transdermal biyo-özdeş progesteron vazomotor semptomların tedavisinde plasebodan daha etkili bulunmamıştır. [16][17][18][19][20] Genel olarak iyi tolere edilmelerine karşın, baş ağrısı ve kısa süreli vajinal kanamalar yakınma nedeni oluşturmuştur. 20 AMERİKAN KADIN HASTALIKLARI VE DOĞUM (ACOG) VE ÜREME TIBBI (ASRM) UZMAN DERNEK GÖRÜŞLERİ 21,22 1.…”

Section: İstenmeyen Etki̇ler Görülebi̇li̇r Mi̇?unclassified

“…[16][17][18][19][20] Genel olarak iyi tolere edilmelerine karşın, baş ağrısı ve kısa süreli vajinal kanamalar yakınma nedeni oluşturmuştur. 20 AMERİKAN KADIN HASTALIKLARI VE DOĞUM (ACOG) VE ÜREME TIBBI (ASRM) UZMAN DERNEK GÖRÜŞLERİ 21,22 1. Biyo-özdeş ısmarlama alaşım bileşimlerinin geleneksel, ticari menopoz hormon tedavilerine üs-tünlüklerini gösteren bir kanıt yoktur.…”

Section: İstenmeyen Etki̇ler Görülebi̇li̇r Mi̇?unclassified

Bio-Identical Hormones: Estrogen and Progesterone: Review

Biberoğlu¹,

Biberoğlu²

2017

Turkiye Klinikleri J Gynecol Obst

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Ö ÖZ ZE ET T "Women's Health Initiative WHI" çalışmasının 2002 yılında yayımlanmasını takiben, pek çok menopozal kadın ya hormon tedavisi almayı reddetmiş ya da almakta oldukları hormon ilaçla-rını kesmişlerdir. Bunun arkasından biyo-özdeş hormon tedavilerinde bir artış baş göstermiştir. Biyo-özdeş moleküller, bitkilerin belirli ekstrelerinden konsantre edilmektedirler. Amaç, vücudun kendi endokrin sisteminin ürettiği doğal hormonları taklit etmektir. Biyo-özdeş terim, genellikle reçete edilen formüle uygun olarak ihtiyacı olan kişiye özel üretilen kimyasal formülasyon olarak tanımlanmaktadır. En sık olarak östriol, östron, östradiol, testosteron, progesteron ve dehidroepiandrosteron formları vardır. Bununla birlikte, biyo-özdeş maddeler tam olarak doğal hormonlar olmayıp, laboratuvarda birçok şekilde değişikliğe uğramaktadır. Genellikle etkinlik ve güvenirlilikleri test edilmediği gibi, herhangi bir uluslararası ilaç kurumu tarafından da onaylanmamışlardır. Son zamanlarda bazı aktif içerikler ABD Besin ve İlaç Denetleme Kurumu ve Avrupa Tıp Ajansı tarafından onaylanmaya başlanmıştır. Temel amaç, sağlığa yararlı, minimal risk taşıyan, bireyselleştirilmiş ve yaşam kalitesini artıran tedaviler oluşturmaktır.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Östojen yerine koyma tedavisi; hormon replasman tedavisi; östrojenler; progesteron

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“…4,18 A recent review of RCTs also concluded that bioidentical progesterone cream is not effective for the relief of vasomotor symptoms associated with menopause. 19 FDA-approved progestogens (including the bioidentical variety of oral micronized progesterone) are the only preparations that have been proven to reliably protect women from endometrial hyperplasia and cancer and should be included in the HT regimen for any woman with a uterus. Compounded preparations of BHT that are not FDA-approved may provide women with a false sense of protection from endometrial cancer.…”

Section: Casementioning

confidence: 99%

Risks and Effectiveness of Compounded Bioidentical Hormone Therapy: A Case Series

Davis

Batur

Thacker

2014

Journal of Women's Health

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After the publication of the Women's Health Initiative, attitudes towards management of menopausal symptoms changed dramatically. One alternative that has received much media attention is the use of bioidentical hormone therapy (BHT). The media and celebrity endorsements have promoted a number of misconceptions about the risks and benefits associated with the various forms of BHT. This article will review the available evidence regarding the safety and efficacy of BHT in comparison to conventional hormone therapy. We will also review several cases seen in our midlife women's referral clinics, which demonstrate concerns for the safety and efficacy of BHT, including unexplained endometrial cancer in otherwise healthy BHT users. Due to the lack of sufficient data to support the efficacy or safety of BHT, we recommend the use of United States Food and Drug Administration-approved regimens in the management of menopausal symptoms.

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Bioidentical Progesterone Cream for Menopause-Related Vasomotor Symptoms: Is it Effective?

Abstract: Available evidence from RCTs does not support the efficacy of bioidentical progesterone cream for the management of menopause-related vasomotor symptoms. Adverse effects appear to be mild and self-limiting.

Cited by 14 publications

References 24 publications

Survivorship, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology

Survivorship, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology

Bio-Identical Hormones: Estrogen and Progesterone: Review

Risks and Effectiveness of Compounded Bioidentical Hormone Therapy: A Case Series

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