Bioimaging and toxicity assessments of near-infrared upconversion luminescent NaYF4:Yb,Tm nanocrystals

Zhou, Jia-Cai; Yang, Zhenglin; Dong, Wei; Tang, Ruo-Jin; Sun, Ling‐Dong; Yan, Chun‐Hua

doi:10.1016/j.biomaterials.2011.08.038

Cited by 238 publications

(155 citation statements)

References 41 publications

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“…For example, the synthesis of NaGdF 4 ∶Yb 3þ , Er 3þ nanoparticles have some drawbacks for biomedical applications; therefore, gold or silica need to be used to render them with biocompatible properties. [37][38][39] In addition, one of the problems with carbon nanoparticles is the fact that they need to be excited with near-UV light, which can damage tissues around the cancer cells. 34 Rare earth doped zirconia (ZrO 2 ) nanophosphors present efficient emission in the visible region when they are under IR excitation.…”

Section: Introductionmentioning

confidence: 99%

Labeling of HeLa cells using ZrO 2 : Yb 3 + - Er 3 + nanoparticles with upconversion emission

et al. 2015

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Abstract. This work reports the synthesis, structural characterization, and optical properties of ZrO 2 ∶Yb 3þ -Er 3þ (2-1 mol%) nanocrystals. The nanoparticles were coated with 3-aminopropyl triethoxysilane (APTES) and further modified with biomolecules, such as Biotin-Anti-rabbit (mouse IgG) and rabbit antibody-AntiKi-67, through a conjugation method. The conjugation was successfully confirmed by Fourier transform infrared, zeta potential, and dynamic light scattering. The internalization of the conjugated nanoparticles in human cervical cancer (HeLa) cells was followed by two-photon confocal microscopy. The ZrO 2 ∶Yb 3þ -Er 3þ nanocrystals exhibited strong red emission under 970-nm excitation. Moreover, the luminescence change due to the addition of APTES molecules and biomolecules on the nanocrystals was also studied. These results demonstrate that ZrO 2 ∶Yb 3þ -Er 3þ nanocrystals can be successfully functionalized with biomolecules to develop platforms for biolabeling and bioimaging. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Introductionmentioning

confidence: 99%

Labeling of HeLa cells using ZrO 2 : Yb 3 + - Er 3 + nanoparticles with upconversion emission

et al. 2015

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“…This process, inherent to the Ln 3+ ions, allows for the (up) conversion of low energy excitation (typically near-infrared, NIR) to higher energies. [4][5][6] However, in contrast to most other two-photon excited materials (semiconductor quantum dots, gold nanorods, organic dyes, etc. ), efficient UC emission in the UV-visible-NIR regions from Ln 3+ -doped nanomaterials can be obtained using inexpensive diode NIR lasers (e.g.…”

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confidence: 99%

PEG-capped, lanthanide doped GdF3 nanoparticles: luminescent and T2 contrast agents for optical and MRI multimodal imaging

et al. 2012

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“…The appropriate functionalization of the NP surface and the introduction of targeting molecules such as folic acid, some peptides, specific antibodies and growth factors permits in some cases a cellular targeting imaging [263][264][265]. In vivo luminescent bioimaging of bacteria [266,267], small animals (mostly mice) [268,269] and plants [262,270] with UCNPs has also been widely reported in the literature. Different processes of biomedical interest can be also studied in vivo by using UCNPs, as it is the case of the biodistribution of the NPs [271] and targeting [272][273][274][275].…”

Section: Upconverting Nanophosphors For Luminescent Bioimagingmentioning

confidence: 99%

Rare earth based nanostructured materials: synthesis, functionalization, properties and bioimaging and biosensing applications

et al. 2017

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Abstract:Rare earth based nanostructures constitute a type of functional materials widely used and studied in the recent literature. The purpose of this review is to provide a general and comprehensive overview of the current state of the art, with special focus on the commonly employed synthesis methods and functionalization strategies of rare earth based nanoparticles and on their different bioimaging and biosensing applications. The luminescent (including downconversion, upconversion and permanent luminescence) and magnetic properties of rare earth based nanoparticles, as well as their ability to absorb X-rays, will also be explained and connected with their luminescent, magnetic resonance and X-ray computed tomography bioimaging applications, respectively. This review is not only restricted to nanoparticles, and recent advances reported for in other nanostructures containing rare earths, such as metal organic frameworks and lanthanide complexes conjugated with biological structures, will also be commented on.

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Bioimaging and toxicity assessments of near-infrared upconversion luminescent NaYF4:Yb,Tm nanocrystals

Cited by 238 publications

References 41 publications

Labeling of HeLa cells using ZrO 2 : Yb 3 + - Er 3 + nanoparticles with upconversion emission

Labeling of HeLa cells using ZrO 2 : Yb 3 + - Er 3 + nanoparticles with upconversion emission

PEG-capped, lanthanide doped GdF3 nanoparticles: luminescent and T2 contrast agents for optical and MRI multimodal imaging

Rare earth based nanostructured materials: synthesis, functionalization, properties and bioimaging and biosensing applications

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