Bioinks adapted for in situ bioprinting scenarios of defect sites: a review

Abstract

Design points and applicable scenarios for bioinks in in situ 3D bioprinting.

In Situ Bioprinting: Process, Bioinks, and Applications

“…19 In recent years, materials such as collagen, alginates, gelatin, silk, and polyethylene glycol (PEG) have been utilized in addition to biological or chemical substances to develop bioinks. 26 An ideal bioink must possess specific properties to successfully construct 3D structures, such as controlled extrusion, shear-thinning capability, cross-linking ability, and mechanical properties similar to those of native tissue. 53 However, challenges arise as materials with good mechanical properties may lack an appropriate tissue environment, while those providing a favorable environment for cells may not have the desired physical characteristics for printing.…”

“…Bioinks have emerged as a suitable and promising choice for bioprinting, primarily because they can be designed in 3D without requiring external support . In recent years, materials such as collagen, alginates, gelatin, silk, and polyethylene glycol (PEG) have been utilized in addition to biological or chemical substances to develop bioinks . An ideal bioink must possess specific properties to successfully construct 3D structures, such as controlled extrusion, shear-thinning capability, cross-linking ability, and mechanical properties similar to those of native tissue .…”

“…7,23 Various types of bioinks, including hydrogels, polymers, and decellularized matrices, have been explored for their suitability to support cell viability and tissue development. 26 The choice of bioink depends on the specific requirements of the target tissue and desired mechanical and biological properties. Applications of in situ bioprinting spans a wide range of tissues, including skin, 27 bone, 28 cartilage, 29 and muscle.…”

“…Bioinks, which are materials used for printing, play a pivotal role in the success of in situ bioprinting. , Various types of bioinks, including hydrogels, polymers, and decellularized matrices, have been explored for their suitability to support cell viability and tissue development . The choice of bioink depends on the specific requirements of the target tissue and desired mechanical and biological properties.…”

Advancements of 3D bioprinting in regenerative medicine: Exploring cell sources for organ fabrication

“…Bioink, a combination of seed cells and bioprinting materials, plays a core role in achieving high-density cell distribution within bioprinted structures while maintaining their biological function throughout the 3D-bioprinting process [ 65 , 66 ]. Serving as a delivery and support system, bioink materials ensure the transportation and sustenance of seed cells during bioprinting.…”