Bioinspired and biomimetic micro- and nanostructures in biomedicine

Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency

“…[ 32 ] Another strategy is to engineer biomimetic NPs via coating cell membranes from red blood cells, [ 33 ] platelets, [ 34 ] leukocytes, [ 35 ] or cancer cells [ 36 ] on the surface of NDDSs to prepare camouflaged nanoformulations. [ 37 ] The lifespan of red blood cell membrane with expressed CD47 (an integral membrane protein) can be up to 120 days so the membrane can help maintaining long‐term survival of biomimetic NDDSs during the circulation. [ 38 ] Based on this mechanism, NDDSs with a surface modified with CD47 can inhibit phagocytic clearance and enhance the delivery efficiency.…”

A tumor cell membrane-coated self-amplified nanosystem as a nanovaccine to boost the therapeutic effect of anti-PD-L1 antibody

“…Functionalized nanosized delivery systems have been developed for delivery of therapeutic agents into tumor sites [ 20 , 21 ], and a biomimetic drug delivery system has attracted tremendous attention in recent years [ 22 , 23 ]. Cell membranes from red blood cells [ 24 ], platelets [ 25 ], natural killer cells [ 26 ] and cancer cells [ 27 ] have been used for engineering these biomimetic nanoplatforms.…”

A review on contemporary nanomaterial-based therapeutics for the treatment of diabetic foot ulcers (DFUs) with special reference to the Indian scenario

“…Bionect, Unite Biomatrix, BGC Matrix, Promogran Prisma Matrix, Dermacol/Ag, Aquacel Hydrofiber, Regranex, Medihoney, Algisite, Sorbalgon, Kaltostat, Biatain, DuoDERM, Allevyn, Mepilex Ag and Ligasano are some of the few commercial wound dressings suitable for DFU treatment. 94 However, although these wound dressings minimize pain and trauma to patients, maintain a moist environment, and promote granulation and vascularization to tissues, they still have some limitations such as inadequate flow of blood supply to tissues, frequent wound exudates and inefficient targeted delivery to the wound site. Nanomaterial therapeutics for diabetic wound healing can be subdivided into two main categories, as follows: (1) nanomaterials that show intrinsic characteristics beneficial for the treatment of wound healing and (2) nanomaterials that serve as drug delivery vehicles for encapsulating therapeutic agents/drugs.…”