Bioinspired Copolymers Based Nose/Tongue-Mimic Chemosensor for Label-Free Fluorescent Pattern Discrimination of Metal Ions in Biofluids

Abstract

There is a close correlation between body health and the level of biofluid-derived metal ions, which makes it an attractive model analyte for noninvasive health monitoring. The present work has developed a novel nose/tongue-mimic chemosensor array based on bioinspired polydopamine/polyethylenimine copolymers (PDA/PEI ) for label-free fluorescent determination of metal ions in biofluids. Three types of PDA/PEI (PDA/PEI, PDA/PEI, and PDA/PEI) were prepared by using different concentrations of PEI to construct the proposed sensor array, which would lead to unique fluorescence response patterns upon challenged with metal ions for their pattern discrimination. The results show that as few as 3 PDA/PEI sensors can successfully realize the largescale sensitive detection of metal ions in biofluids. Moreover, we have demonstrated that PDA/PEI sensors are qualified for lifetime-based pattern discrimination application. Furthermore, the sensors can distinguish between different concentrations of metal ions, as well as a mixture of different metal ions in biofluids, even the mixtures with different valence states. The method promises the simple, rapid, sensitive, and powerful discrimination of metal ions in accessible biofluids, showing the potential applications in the diagnosis of metal ion-involved diseases.

Facile Preparation of Highly Luminescent Nitrogen-Doped Carbonaceous Nanospheres and Potential Application in Intracellular Imaging of Quercetin

“…Hence, we speculate that the LNCNs may gradually form by a multistep cross-linked polymerisation. Namely, the enhancement of PL intensity might be attributed to the increase in polyaromatic structures induced by incorporating N atoms and the decrease in intermolecular coupling of b-CD, [30,31] and when the reaction time is 8 h, the greater number of polyaromatic structures in the LNCNs may form more of a structurally rigid plane which results in the highest PL intensity of the LNCNs. At shorter reaction times, the b-CD may react incompletely, reducing the PL intensity.…”

A rhodamine derivative probe for highly selective detection of Cu(II)

“…Emerging fluorescent hybrid nanomaterials includes quantum dots (QDs), metal nanoclusters (NCs), carbon dots (CDs), MXenes and polymer nanoparticles (NPs) [13,14]. Fluorescence chemical sensors are mostly based on the following types: deoxyribonucleic acid [15], fluorophores [16,17], metal-organic framework (MOF) [18], copolymers [19], Schiff bases [20], and silica nanoparticles [21]. Among them, chemical sensors containing fluorophores have attracted much attention.…”

Paper-Based Fluorescence Chemosensors for Metal Ion Detection in Biological and Environmental Samples

“…Owing to their various advantages such as ease of device fabrication, low cost, high stability, and rapid disposability, fluorescence chemosensors have drawn great interest compared with other methods [17,18]. Several synthetically prepared substances, such as DNAzymes [19,20], fluorophores [21,22], metal-organic frameworks (MOFs) [23,24], copolymers [25], Schiff bases [26,27], and silica nanoparticles [28], have so far been used in developing fluorescence chemosensors to detect HMIs. Furthermore, there are several review articles on HMI detection methods achieved using fluorescence chemosensors involving different strategies such as DNA binding [29], host-guest interaction [30], photoinduced electron transfer (PET) [31], and fluorescence resonance energy transfer (FRET) [32].…”