Bioinspired design of mannose-decorated globular lysine dendrimers promotes diabetic wound healing by orchestrating appropriate macrophage polarization

Jiang, Yuhang; Zhao, Wentao; Xu, Shuping; Wei, Jingjing; Lasaosa, Fernando López; He, Yiyan; Mao, Hongli; Bailo, Rosa María Bolea; Gu, Zhongwei

doi:10.1016/j.biomaterials.2021.121323

Cited by 47 publications

(38 citation statements)

References 45 publications

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“…The formation of a diabetic foot ulcer (DFU) is a leading cause of morbidity and death in patients with poorly managed diabetes [ 1 – 4 ], with an estimated 25% of diabetes patients suffering from chronic infectious wounds that fail to properly heal and are associated with a risk of amputation, and the 5-year survival rate with such non-resolving wounds is estimated to be only 32% [ 5 ]. By preventing infection, eliminating injured tissue, and secreting cytokines that stimulate fibroblast migration, angiogenesis, collagen deposition, and wound closure, wound healing could be restored and facilitated [ 6 , 7 ]. Among those above-mentioned risk factors, the systemic abnormalities in normal angiogenesis and vascular growth could hamper diabetic wound healing, resulting from damaged tissues that are insufficiently oxygenated and deprived of essential nutrients [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

MiR-21 regulating PVT1/PTEN/IL-17 axis towards the treatment of infectious diabetic wound healing by modified GO-derived biomaterial in mouse models

et al. 2022

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Background Diabetic foot ulcer (DFU), persistent hyperglycemia and inflammation, together with impaired nutrient and oxygen deficiency, can present abnormal angiogenesis following tissue injury such that these tissues fail to heal properly. It is critical to design a new treatment method for DFU patients with a distinct biomechanism that is more effective than current treatment regimens. Method Graphene oxide (GO) was combined with a biocompatible polymer as a kind of modified GO-based hydrogel. The characterization of our biomaterial was measured in vitro. The repair efficiency of the biomaterial was evaluated in the mouse full-skin defect models. The key axis related to diabetic wound (DW) was identified and investigated using bioinformatics analyses and practical experiments. Result In the study, we found that our modified GO-based wound dressing material is a promising option for diabetic wound. Secondly, our biomaterial could enhance the secretion of small EVs (sEVs) with more miR-21 by adipose-derived mesenchymal stem cells (AD-MSCs). Thirdly, the PVT1/PTEN/IL-17 axis was found to be decreased to promote DFU wound healing by modifying miR-21 with the discovery of PVT1 as a critical LncRNA by bioinformatics analysis and tests. Conclusion These findings could aid in the development of clinical care strategies for DFU wounds.

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Section: Introductionmentioning

confidence: 99%

MiR-21 regulating PVT1/PTEN/IL-17 axis towards the treatment of infectious diabetic wound healing by modified GO-derived biomaterial in mouse models

et al. 2022

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“…Although this in vivo study did not examine bone defect repair, it demonstrated that MGLDs could enhance cutaneous wound healing in a diabetic mouse model. [ 143 ]…”

Section: Electroactive Scaffolds Can Facilitate Bone Regeneration Und...mentioning

confidence: 99%

“…Electrical stimulation has also been shown to significantly promote macrophage phagocytic uptake, selectively regulate cytokine production, [140] and facilitate the transition of macrophages from the proinflammatory M1 to the pro-healing M2 phenotype. [141][142][143] Dai et al [141] reported that hyperglycemia associated with diabetes resulted in the polarization of macrophages toward the proinflammatory M1 phenotype, which in turn hindered bone defect healing. This was attenuated by covering the bone defect site with a BTO/P(VDF-TrFE) ferroelectric nanocomposite membrane, which restored the physiological electrical microenvironment of the bone under diabetic conditions.…”

Section: Immunomodulatory Effectsmentioning

confidence: 99%

Electroactive Biomaterials for Facilitating Bone Defect Repair under Pathological Conditions

Heng

Bai

et al. 2022

Advanced Science

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Bone degeneration associated with various diseases is increasing due to rapid aging, sedentary lifestyles, and unhealthy diets. Living bone tissue has bioelectric properties critical to bone remodeling, and bone degeneration under various pathological conditions results in significant changes to these bioelectric properties. There is growing interest in utilizing biomimetic electroactive biomaterials that recapitulate the natural electrophysiological microenvironment of healthy bone tissue to promote bone repair. This review first summarizes the etiology of degenerative bone conditions associated with various diseases such as type II diabetes, osteoporosis, periodontitis, osteoarthritis, rheumatoid arthritis, osteomyelitis, and metastatic osteolysis. Next, the diverse array of natural and synthetic electroactive biomaterials with therapeutic potential are discussed. Putative mechanistic pathways by which electroactive biomaterials can mitigate bone degeneration are critically examined, including the enhancement of osteogenesis and angiogenesis, suppression of inflammation and osteoclastogenesis, as well as their anti‐bacterial effects. Finally, the limited research on utilization of electroactive biomaterials in the treatment of bone degeneration associated with the aforementioned diseases are examined. Previous studies have mostly focused on using electroactive biomaterials to treat bone traumatic injuries. It is hoped that this review will encourage more research efforts on the use of electroactive biomaterials for treating degenerative bone conditions.

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“…Peptide dendrimers and dendritic peptide polymers (Fig. 1) have also been introduced into wound management by our group 95,[146][147][148] and others [149][150][151][152][153][154] and exhibited exceptional antibacterial and adhesive performance attributed to their highly symmetrical structure with multiple peripheral reactive groups. Precise design of dendrimers allows fine control of molecular structure and composition while providing multiple functions 114,149 in wound repairing such as considerable mechanical enhancement for open wound contraction, 95 immunomodulation, 148,153 and bacteria elimination, 95,154 due to the multivalent effect of dendrimers (Fig.…”

Section: Polypeptides and Peptides-based Polymersmentioning

confidence: 99%

Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management

Mao

et al. 2022

J. Mater. Chem. B

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Bioinspired design of mannose-decorated globular lysine dendrimers promotes diabetic wound healing by orchestrating appropriate macrophage polarization

Cited by 47 publications

References 45 publications

MiR-21 regulating PVT1/PTEN/IL-17 axis towards the treatment of infectious diabetic wound healing by modified GO-derived biomaterial in mouse models

MiR-21 regulating PVT1/PTEN/IL-17 axis towards the treatment of infectious diabetic wound healing by modified GO-derived biomaterial in mouse models

Electroactive Biomaterials for Facilitating Bone Defect Repair under Pathological Conditions

Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management

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