Bioinspired Design of Ultrathin 2D Bimetallic Metal–Organic‐Framework Nanosheets Used as Biomimetic Enzymes

Wang, Yixian; Zhao, Meiting; Ping, Jianfeng; Chen, Bin; Cao, Xiehong; Huang, Ying; Tan, Chaoliang; Ma, Qinglang; Wu, Shixin; Yu, Yifu; Lu, Qipeng; Chen, Junze; Zhao, Wei; Ying, Yibin; Zhang, Hua

doi:10.1002/adma.201600108

Cited by 478 publications

(276 citation statements)

References 47 publications

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“…[1][2][3][4][5][6][7] As a new member in the family of ultrathin 2D nanomaterials, 2D metal-organic framework (MOF) nanosheets have also received great research interest. [9][10][11][12][13] Compared to the bulk MOF crystals, 2D MOF nanosheets possess unique advantages. [9][10][11][12][13] Compared to the bulk MOF crystals, 2D MOF nanosheets possess unique advantages.…”

Section: Biomimetic Catalysismentioning

confidence: 99%

“…[13,14] In addition, ultrathin 2D MOF nanosheets also favor the permeation of gas molecules in gas separation. [13,14] In addition, ultrathin 2D MOF nanosheets also favor the permeation of gas molecules in gas separation.…”

mentioning

confidence: 99%

“…[15] Inspired by natural enzymes, tremendous research efforts have been devoted to the development of artificial enzymes to mimic the functions of natural enzymes. [12,13] Although the aforementioned metalloporphyrin-based MOFs have been successfully used as peroxidase mimics, they can only be used to mimic one kind of enzymes. Very recently, our group prepared the iron porphyrin-based 2D MOF nanosheets and studied their properties and biosensing applications.…”

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confidence: 99%

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Growth of Au Nanoparticles on 2D Metalloporphyrinic Metal‐Organic Framework Nanosheets Used as Biomimetic Catalysts for Cascade Reactions

et al. 2017

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Inspired by the multiple functions of natural multienzyme systems, a new kind of hybrid nanosheet is designed and synthesized, i.e., ultrasmall Au nanoparticles (NPs) grown on 2D metalloporphyrinic metal-organic framework (MOF) nanosheets. Since 2D metalloporphyrinic MOF nanosheets can act as the peroxidase mimics and Au NPs can serve as artificial glucose oxidase, the hybrid nanosheets are used to mimic the natural enzymes and catalyze the cascade reactions. Furthermore, the synthesized hybrid nanosheets are used to detect biomolecules, such as glucose. This study paves a new avenue to design nanomaterial-based biomimetic catalysts with multiple complex functions.

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Section: Biomimetic Catalysismentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Growth of Au Nanoparticles on 2D Metalloporphyrinic Metal‐Organic Framework Nanosheets Used as Biomimetic Catalysts for Cascade Reactions

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“…2019, 6, 1802373 direct synthesis of 2D MOFs in bulk solution is relatively effective in regulating the size and thickness of 2D nanosheets. [75,168,169] As illustrated in Figure 9a, bulk Zn-TCPP crystals with layered structure were formed without addition of surfactants in the synthetic process. [48,56,84] It is well known that surfactant is able to selectively attach to a certain crystallographic plane, which decreases surface energy and promotes anisotropic growth of crystal.…”

Section: Bulk Solution Preparationmentioning

confidence: 99%

“…[168] Then, the nanosheets were transferred to substrates, such as Si wafer or glassy carbon (GC), to form 2D MOF-based thin films, which were used as electrochemical platforms to detect H 2 O 2 (Figure 19a). For example, Zhang and co-workers first prepared ultrathin 2D MOF nanosheets, i.e., Co-TCPP(Fe), through a surfactant-assisted method.…”

Section: Sensingmentioning

confidence: 99%

Structural Engineering of Low‐Dimensional Metal–Organic Frameworks: Synthesis, Properties, and Applications

et al. 2019

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Low‐dimensional metal–organic frameworks (LD MOFs) have attracted increasing attention in recent years, which successfully combine the unique properties of MOFs, e.g., large surface area, tailorable structure, and uniform cavity, with the distinctive physical and chemical properties of LD nanomaterials, e.g., high aspect ratio, abundant accessible active sites, and flexibility. Significant progress has been made in the morphological and structural regulation of LD MOFs in recent years. It is still of great significance to further explore the synthetic principles and dimensional‐dependent properties of LD MOFs. In this review, recent progress in the synthesis of LD MOF‐based materials and their applications are summarized, with an emphasis on the distinctive advantages of LD MOFs over their bulk counterparties. First, the unique physical and chemical properties of LD MOF‐based materials are briefly introduced. Synthetic strategies of various LD MOFs, including 1D MOFs, 2D MOFs, and LD MOF‐based composites, as well as their derivatives, are then summarized. Furthermore, the potential applications of LD MOF‐based materials in catalysis, energy storage, gas adsorption and separation, and sensing are introduced. Finally, challenges and opportunities of this fascinating research field are proposed.

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Metal–Organic Frameworks as Enzyme Mimics

Liebing¹,

Kulak²

2021

Encyclopedia of Inorganic and Bioinorganic Chemistry

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In this article we are presenting the design of metal–organic frameworks (MOFs) for applications as enzyme mimics (artificial enzymes). MOFs have been the topic of current and intense research for various applications ranging from gas storage, catalysis, to sensing. Their biocatalytic activity, however, has been discovered and investigated only recently—literature exists only for the past decade. High stability also at harsh conditions, low cost, and activity that can be tailored are advantages that compete oftentimes lower activity in comparison to the natural enzymes. Among the nanomaterials with enzymatic activity (nanozymes), MOFs are of special potential, since it is possible to mimic not only the active site of an enzyme but also its microenvironment. We firstly introduce MOFs along with synthetic strategies and secondly give an overview of their nanozymatic activity for oxidation and hydrolytic reactions. This activity has found many applications in biosensing and biomedicine, which are presented in the last chapter of this article. Medicinal applications cover cancer and antimicrobial therapy.

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Bioinspired Design of Ultrathin 2D Bimetallic Metal–Organic‐Framework Nanosheets Used as Biomimetic Enzymes

Abstract: With the bioinspired design of organic ligands and metallic nodes, novel ultrathin 2D bimetallic metal-organic-framework nanosheets are successfully synthesized, which can serve as advanced 2D biomimetic nanomaterials to mimic heme proteins.

Cited by 478 publications

References 47 publications

Growth of Au Nanoparticles on 2D Metalloporphyrinic Metal‐Organic Framework Nanosheets Used as Biomimetic Catalysts for Cascade Reactions

Growth of Au Nanoparticles on 2D Metalloporphyrinic Metal‐Organic Framework Nanosheets Used as Biomimetic Catalysts for Cascade Reactions

Structural Engineering of Low‐Dimensional Metal–Organic Frameworks: Synthesis, Properties, and Applications

Metal–Organic Frameworks as Enzyme Mimics

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