Bioinspired nanoarchitectonics as emerging drug delivery systems

Abstract

Bioinspired nanoarchitectonics opens a new era for designing drug delivery systems.

Synthesis, characterisation and antimicrobial activity of manganese- and iron-doped zinc oxide nanoparticles

“…[13À15] Ariga et al proposed the new concept of bioinspired nanoarchitectonics as emerging drug delivery systems. [16] The polymer-based NP drug delivery system can also be designed to improve the pharmacokinetics and bio distribution of the drug. [17] Nakanishi et al have summarised the biological applications, especially cell growth, sensing, and control using nanoarchitectures of nanocarbons.…”

Water soluble PEG-conjugate of xanthine oxidase inhibitor, PEG–AHPP micelles, as a novel therapeutic for ROS related inflammatory bowel diseases

“…Regarding this issue, EPR effect is a promising concept for targeting tumor as well as inflammation. Namely, because of the pathophysiological and anatomical characteristics of vasculatures in inflamed and tumor tissues, macromolecules larger than 40-50 kDa or of nano sizes will accumulate more predominantly in those tissues than normal tissues [23][24][25] pegylated interferon are now used widely in clinic for cancer and hepatitis, respectively, and more are in the stages of clinical trails [24][25][26][27][28][29]. All of these nanomedicines show superior pharmacokinetics, better therapeutical effects and less side effects compared with conventional low molecular weight drugs.…”

“…The EPR effect is a unique pathophysiological phenomenon in most solid tumors and inflammatory tissues by which macromolecules would selectively extravasated via the blood vessels because of extensively produced various vascular permeability factors such as bradykinin, nitric oxide (NO), and vascular endothelial growth factor [23][24][25]. Many macromolecular drugs have been developed on the basis of the EPR effect [24][25][26][27][28][29]. Inflammatory tissues are similar to tumor tissues except that the retention of the macromolecular drugs is not that complete, which may be slowly recovered.…”

Effects of geometrical confinement in membrane pores on enzyme-based layer-by-layer assemblies

“…As originally described [6,7], LbL assembly consists of the alternate adsorption of a polyanion and a polycation onto oppositely charged surfaces. In the last twenty years, a variety of biomolecules e.g., proteins, virus, colloids and polysaccharides, have been incorporated in LbL films [3,[8][9][10][11].…”