Bioinspired sequentially crosslinked nanofibrous hydrogels with robust adhesive and stretchable capability for joint wound dressing

Highly Adhesive, Stretchable and Breathable Gelatin Methacryloyl-based Nanofibrous Hydrogels for Wound Dressings

“…The cell proliferation on the nanofibrous hydrogels was significantly higher compared with that on TCPS, and the GelMA60-DA nanofibrous hydrogels exhibited the best proliferation, which was 2.2, 1.4, and 1.2 times those of TCPS, and gelatin, and GelMA60 nanofibrous hydrogels, respectively (Figure c). The introduction of DA to the hydrogels has proved to enhance the adhesion between cells and scaffolds, which would improve cell spreading and proliferation . The GelMA60-DA nanofibrous hydrogels composed of ECM-like fibrous architecture and the GelMA–DA component would offer a favorable microenvironment for cell adhesion, survival, and proliferation …”

“…The introduction of DA to the hydrogels has proved to enhance the adhesion between cells and scaffolds, which would improve cell spreading and proliferation. 41 The GelMA60-DA nanofibrous hydrogels composed of ECM-like fibrous architecture and the GelMA−DA component would offer a favorable microenvironment for cell adhesion, survival, and proliferation. 42 3.4.…”

Leveraging the advancements in functional biomaterials and scaffold fabrication technologies for chronic wound healing applications

“…Various bioadhesive bandages have been developed to improve drug delivery to the wound site. 38,39 Chitosan and poly(acrylic acid) are among them and they possess extensive mucoadhesive properties. 40,41 Adhesion to skin occurs when hydrogen bonds from poly(acrylic acid) react with the mucosa, while negatively charged surfaces and cells interact electrostatically with positively charged chitosan molecules.…”

Bioinspired aligned wrinkling dressings for monitoring joint motion and promoting joint wound healing

“…8 Similarly, Ding and coworkers constructed a novel dopamine-modified gelatin hydrogel dressing with robust adhesive and stretchable properties for treating joint wounds. 9 As can be seen, recent advances for treating joint wounds are focused on the design of dressings with high elasticity; [10][11][12] unfortunately, due to the lack of real-time motion sensing functions, the rate and also quality of wound healing may be influenced. Thus, there is still an urgent need to design novel dressings with simultaneous motion monitoring and promoted healing effects for joint wound management.…”