Leveraging the advancements in functional biomaterials and scaffold fabrication technologies for chronic wound healing applications

Abstract

Exploring new avenues for clinical management of chronic wounds holds the key to eliminate socioeconomic burdens and health-related concerns associated with this silent killer. Engineered biomaterials offer great promise to...

Recombinant Human Collagen Hydrogel Rapidly Reduces Methylglyoxal Adducts within Cardiomyocytes and Improves Borderzone Contractility after Myocardial Infarction in Mice

“…[29,34,35] Therefore, our findings may have a significant longitudinal impact in the field of biomaterials and tissue engineering. For any therapeutic material that is produced from peptides, proteins, or other components that could be a target for MG modification (e.g., decellularized extracellular matrix, collagens, fibrin, laminin, hyaluronic acid, chitosan), [36][37][38] the ability to soak up MG should be considered when assessing the mechanism of repair. It is possible that beneficial effects reported with the use of a therapeutic biomaterial for treating many injuries/diseases could be, at least in part, secondary to the ability of the material to remove MG and limit MG-induced damage.…”

Roles and current applications of S-nitrosoglutathione in anti-infective biomaterials

“…In contrast, in situ hydrogel-forming powders could benefit from the advantages of both hydrogels and powders, such as high storage stability, plastic shapes fitting the wound surface, application even in the bendable areas of the body, protecting the wound area from the external environment, and maintaining a moist environment by absorbing fluid and converting it to a hydrogel [ [98] , [99] , [100] ]. In addition, fluid absorption during hydrogel formation is beneficial for bacterial elimination and wound healing [ [101] , [102] , [103] ]. An on-site hydrogel-forming powder comprising GSNO pectin, alginate, and PEG was manufactured through blending and micronizing, which remained stable for >4 months under 4° or 37 ​°C ( Fig.…”

Construction of multifunctional wound dressings with their application in chronic wound treatment

“…9 Professor Guo's group recently conducted comprehensive reviews of multifunctional hydrogels, multifunctional photoactive hydrogels, and smart wound dressings for wound repair, respectively, [21][22][23] and Paul et al reviewed the advancements in functional biomaterials and scaffolds for chronic wound healing. 24 Moreover, Nosrati et al discussed the recent advances in wound dressings with pro-angiogenic properties. 25 In addition, there were also some reviews that discussed smart dressings with certain responsive mechanisms.…”