Wearable electronics offer incredible benefits in mobile healthcare monitoring, sensing, portable energy harvesting and storage, human-machine interactions, etc., due to the evolution of rigid electronics structure to flexible and stretchable devices. Lately, transition metal carbides and nitrides (MXenes) are highly regarded as a group of thriving two-dimensional nanomaterials and extraordinary building blocks for emerging flexible electronics platforms because of their excellent electrical conductivity, enriched surface functionalities, and large surface area. This article reviews the most recent developments in MXene-enabled flexible electronics for wearable electronics. Several MXeneenabled electronic devices designed on a nanometric scale are highlighted by drawing attention to widely developed nonstructural attributes, including 3D configured devices, textile and planer substrates, bioinspired structures, and printed materials. Furthermore, the unique progress of these nanodevices is highlighted by representative applications in healthcare, energy, electromagnetic interference (EMI) shielding, and humanoid control of machines. The emerging prospects of MXene nanomaterials as a key frontier in nextgeneration wearable electronics are envisioned and the design challenges of these electronic systems are also discussed, followed by proposed solutions.