Biología, patobiología y bioclínica de la homocisteína eh la especie humana

García, Grégory Alfonso

doi:10.31260/repertmedcir.v19.n2.2010.586

Cited by 2 publications

(2 citation statements)

References 94 publications

(102 reference statements)

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“…Vitamin C prolonged treatment showed anti-inflammatory effect with reduced reactive oxygen and nitrogen species, increasing the bioavailability of NO and inhibing the formation of peroxynitrite. The L-ascorbic acid donates two electrons from a double bond between carbons at positions 2 and 3, this action would preserve the physiological functions of NO by intracellular superóxide ion chelation [33,34].…”

Section: Discussionmentioning

confidence: 99%

Nitrotyrosine as a biomarker: recovery of histopathological atherogenic lesions in rats treated with ascorbic acid

Báez¹,

Scribano²,

Tarán³

et al. 2018

Trends Med

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Aims: To value the antioxidant effect of vitamin C on atherogenesis induced by oxidative stress, using nitric oxide, superoxide dismutase and nitrotyrosine as biomarkers.Main methods: Wistar rats were used: (A) Control; (B) Proinflammatory Induction for 30 days, (C) Proinflammatory Induction for 30 days+Vitamin C, (D) Proinflammatory Induction for 60 days and (E) Proinflammatory Induction for 60 days+Vitamin C. Proinflammatory Induction with adrenaline (0.1 mg/day/rat). Vitamin C (2,14 mg/day/rat) administered 20 days in (C) and 50 days in (E). Nitric oxide (NO) (µM) and superoxide dismutase(U/ml) were estimated employing spectrophotometry, nitrotyrosine (nM) employing Elisa and histopathological sections were analyzed by optical microscopy. ANOVA was used for quantitative variables and square Chi was used for categorical variables, significance p<0.05 was stablished in all cases. Key findings: In groups (B) (12.23±1.14) and (D) (17.84±1.7) NO decreased compared with (A) (22.46±1.24) (p<0.001, p<0.01). NO normalization was found in (E) (21.78±1.9). Superoxide dismutase showed significantly increased in (B) (159.33±5.56) and (D) (241±5.6) compared to (A) (128.7±5) (p<0.01, p<0.001). Similar augment showed groups (C) (185.12±6.3) and (E) (298.75±3.17) compared with (A) (p<0.01, p<0.001). Nitrotyrosine was increased in (B) (5.03±0.1) and (D)(5.31±0.12) according to proinflammatory induction and decreased in (C) (2.28±0.32) when compared with (B) (p<0.001). Similar response showed (E) (0.73±0.4) compared with (D) (p<0.001). In groups (B) and (D) showed endothelial denudation, intimal thickening and vascular layers disorganization. Group (E) showed a reversal of the lesions described.Significance: nitrotyrosine is a useful marker of peroxynitrite production and oxidative damage to endothelial cells. Vitamin C reversed the oxidative stress but did not reverse the atherogenic lesions in endothelial.

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Section: Discussionmentioning

confidence: 99%

Nitrotyrosine as a biomarker: recovery of histopathological atherogenic lesions in rats treated with ascorbic acid

Báez¹,

Scribano²,

Tarán³

et al. 2018

Trends Med

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“…Molecular docking studies revealed that rosmarinic acid is bounded to the hyaluronidase binding pocket with four binding interactions [52]. In our study, the hyaluronidase used was not human but bovine, but these are highly phylogenetically conserved proteins [53]. Another compound that has been tested in silico against collagenase, elastase, and tyrosinase enzymes is caffeine, which was shown to form a stable protein-ligand complex validated by molecular dynamics simulation.…”

Section: Discussionmentioning

confidence: 75%

Evaluation of Bioactive Effects of Five Plant Extracts with Different Phenolic Compositions against Different Therapeutic Targets

Villegas-Aguilar,

Sánchez-Marzo,

Fernández-Ochoa

et al. 2024

Antioxidants

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Plant extracts rich in phenolic compounds have been reported to exert different bioactive properties. Despite the fact that there are plant extracts with completely different phenolic compositions, many of them have been reported to have similar beneficial properties. Thus, the structure–bioactivity relationship mechanisms are not yet known in detail for specific classes of phenolic compounds. In this context, this work aims to demonstrate the relationship of extracts with different phenolic compositions versus different bioactive targets. For this purpose, five plant matrices (Theobroma cacao, Hibiscus sabdariffa, Silybum marianum, Lippia citriodora, and Olea europaea) were selected to cover different phenolic compositions, which were confirmed by the phytochemical characterization analysis performed by HPLC-ESI-qTOF-MS. The bioactive targets evaluated were the antioxidant potential, the free radical scavenging potential, and the inhibitory capacity of different enzymes involved in inflammatory processes, skin aging, and neuroprotection. The results showed that despite the different phenolic compositions of the five matrices, they all showed a bioactive positive effect in most of the evaluated assays. In particular, matrices with very different phenolic contents, such as T. cacao and S. marianum, exerted a similar inhibitory power in enzymes involved in inflammatory processes and skin aging. It should also be noted that H. sabdariffa and T. cacao extracts had a low phenolic content but nevertheless stood out for their bioactive antioxidant and anti-radical capacity. Hence, this research highlights the shared bioactive properties among phenolic compounds found in diverse matrices. The abundance of different phenolic compound families highlights their elevated bioactivity against diverse biological targets.

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Biología, patobiología y bioclínica de la homocisteína eh la especie humana

Cited by 2 publications

References 94 publications

Nitrotyrosine as a biomarker: recovery of histopathological atherogenic lesions in rats treated with ascorbic acid

Nitrotyrosine as a biomarker: recovery of histopathological atherogenic lesions in rats treated with ascorbic acid

Evaluation of Bioactive Effects of Five Plant Extracts with Different Phenolic Compositions against Different Therapeutic Targets

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