Biologic Mechanisms Linked to Prognosis in Ovarian Cancer that May Be Affected by Aging

Chon, Hye Sook; Sehovic, Marina; Marchion, Douglas C.; Walko, Christine M.; Xiong, Yin; Extermann, Martine

doi:10.7150/jca.29611

Cited by 10 publications

(6 citation statements)

References 177 publications

(181 reference statements)

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“…On the other hand, EOC consists of a heterogeneous group of neoplasms with multiple histologic subtypes [ 30 ]. The differences of tumor biology may also be associated with inherent platinum resistance [ 31 ]. It is worth noting that clear cell cancer constitutes a larger percentage of ovarian cancers in East Asia and have a poorer prognosis compared to serous cancers [ 19 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Do ethnic chinese older adults with epithelial ovarian cancer survive a poorer prognosis?

et al. 2023

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Background The risk of suffering epithelial ovarian cancer (EOC) for women increases with age evidently, while the prognosis of older EOC patients remain unclear. Against the backdrop of the accelerate aging process in China, this paper investigates whether the older EOC patients have a lower overall survival probability than the younger patients based on the sample of ethnic Chinese population. Methods A total of 323 ethnic Chinese patients diagnosed as epithelial ovarian cancer were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. We compared the overall survival probability between the younger group (< 70 years) and the older patients group (≥ 70 years). Survival curves were drawn using the Kaplan-Meier method, comparisons among different subgroups were evaluated using log-rank tests, and independent prognostic factors were identified by univariate and multivariate Cox regression analyses. Results 43 patients were (13.3%) in the older patients group and 280 (86.7%) in the younger group. The distribution patterns between two groups were significantly different with regard to marital status, histologic type and FIGO stage. The median overall survival (OS) was significantly longer in the younger group than the older patients group (not reached vs. median 39 months, p < 0.05). The multivariate analysis demonstrated that the age (The older vs. the younger, HR: 1.967, P = 0.007), primary tumor laterality (HR: 1.849, P = 0.009), and FIGO stage (III vs. I, HR: 3.588, P = 0.001; and IV vs. I, HR: 4.382, P = 0.001; respectively) remained as important risk factors while Histology (HGSOC vs. CCOC, HR: 0.479, P = 0.025; and LGSOC/MOC/EC vs. CCOC, HR: 0.390, P = 0.034; respectively) and the number of lymph node dissected more than 10 was a protective factor (HR: 0.397, P = 0.008). In an analysis of 104 pairs of patients matched on the basis of the propensity score, the older patients group had significantly lower overall mortality (HR = 2.561, P = 0.002). Conclusion Ethnic Chinese Older EOC patients have a worse prognosis than the younger patients.

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Section: Discussionmentioning

confidence: 99%

Do ethnic chinese older adults with epithelial ovarian cancer survive a poorer prognosis?

et al. 2023

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“…On the other hand, EOC consists of a heterogeneous group of neoplasms with multiple histologic subtypes (22). The differences of tumor biology may also be associated with inherent platinum resistance (23). It is worth noting that clear cell cancer constitutes a larger percentage of ovarian cancers in East Asia [20] .…”

Section: Discussionmentioning

confidence: 99%

Do Chinese older adults with epithelial ovarian cancer survive a poorer prognosis?

Huang

Bao

Luo

et al. 2022

Preprint

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Background: The risk of suffering epithelial ovarian cancer (EOC) for women increasing with age evidently, while the prognosis of older EOC patients remain unclear. Against the backdrop of the accelerate aging process in China, this paper investigates whether the older EOC patients have a lower overall survival probability than the younger patients based on the sample of ethnic Chinese population.Methods: A total of 323 ethnic Chinese patients diagnosed as epithelial ovarian cancer were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. We compared the overall survival probability between the younger group (<65 years) and the older patients group (≥65years). Survival curves were drawn using the Kaplan-Meier method, comparisons among different subgroups were evaluated using log-rank tests, and independent prognostic factors were identified by univariate and multivariate Cox regression analyses.Results: 61 patients were (18.9 %) in the older patients group and 262 (81.1%) in the younger group. The distribution patterns between two groups were significantly different with regard to marital status, histologic type and FIGO stage. The median overall survival (OS) was significantly longer in the younger group than the older patients group (not reached vs median 50 months, p<0.05). Univariate Cox regression analysis showed that age, as well as primary tumor laterality, tumor histological grading, histology, FIGO stage, surgical range and the number of lymph nodes dissected were significantly associated with OS. However, the multivariate analysis demonstrated that the age no longer had an independent impact on overall survival once other confounding variables were controlled (HR: 1.334, P=0.226). Only primary tumor laterality, histology, and FIGO stage, were independent risk factors (HR: 1.885, P=0.008; HR: 2.003, P=0.035; HR: 4.006, P=0.008 and HR: 5.272, P<0.001; HR: 1.885, P=0.008). Moreover, the number of lymph nodes dissected more than 10 was a protective factor (HR: 0.397, P=0.008).Conclusion: Older EOC patients have a worse prognosis than the younger patients largely, but not directly and independently. FIGO stage still stands as the most potent risk factor for older patients’ survival.

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“…Several studies have shown that the prognosis of elderly patients with TC is relatively poor (20)(21)(22). In addition, the relationship between older age and poor survival prognosis has been reported in many types of cancer (23)(24)(25). Highly DTC is the only malignant tumor that has been included in TNM staging by the AJCC (26).…”

Section: Discussionmentioning

confidence: 99%

A nomogram for predicting overall survival in patients with follicular thyroid cancer after thyroidectomy: a SEER database analysis

Wang¹,

Wu²,

Chen³

et al. 2022

Gland Surg

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Background: A good predictive model requires patient participation in prognostic counseling and subsequent clinical follow-up. We aimed to construct and validate a nomogram for predicting overall survival (OS) in patients with follicular thyroid cancer (FTC) after thyroidectomy.Methods: This was a retrospective observational study. We screened 802 patients with initially diagnosed FTC from the Surveillance Epidemiology and End Results (SEER) database between 2010 and 2015. Then the patients were all divided into the training set and validation set randomly at a ratio of 7:3. Univariate and multivariate Cox proportional hazard models were used to analyze the influence of different variables on OS. The concordance index (C-index) and calibration curves were used to evaluate the precision of the nomogram. Results: Univariate and multivariate analyses demonstrated that four factors, namely age, grade, race, and M stage (all P<0.05), were independent predictors of OS in FTC patients. Based on these factors, a predictive model was established by using the training cohort and validated by the validation cohort. A good consistency between the actual OS and predicted OS was showed by the calibration curves. Moreover, compared with the traditional tumor-node-metastasis (TNM) staging system, the nomogram had better predictive ability for the survival of patients with FTC. The C-index of the nomogram in the training set and validation set had high consistency in evaluating the survival rate of patients with FTC [training set: C-index

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Biologic Mechanisms Linked to Prognosis in Ovarian Cancer that May Be Affected by Aging

Cited by 10 publications

References 177 publications

Do ethnic chinese older adults with epithelial ovarian cancer survive a poorer prognosis?

Do ethnic chinese older adults with epithelial ovarian cancer survive a poorer prognosis?

Do Chinese older adults with epithelial ovarian cancer survive a poorer prognosis?

A nomogram for predicting overall survival in patients with follicular thyroid cancer after thyroidectomy: a SEER database analysis

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