Biologic variation of human serum immunoglobulin concentrations: Sex-age specific effects

Abstract

INTRODUCTION SERUM immunoglobulin determinations are of potential value to clinicians in evaluating immunoinflammatory diseases and in the detection and characterization of immunodeficiency or hypergammaglobulinemia. Certain biologic variables affect concentrations of serum immunoglobulins [l-4] and must be considered in interpretation of specific levels in any individual patient. Efforts by different authors to determine general norms of immunoglobulin concentrations and lifetime trends have diverged considerably. The present study of sex and age effects on serum concentrations of JgG, IgA, and IgM is based on data from a large unselected group of subjects from a single community. Study group MATERIALS AND METHODS 3213 consecutive sera were obtained in a community health study in Tecumseh, Michigan (42"N latitude, 83"W longitude) from May 1968 to April 1969. All individuals were of the white race. Sera were divided aseptically into aliquots and stored at 4°C; they were either assayed within a week or frozen at-70°C until analysis. Preparation of puriJed immunoglobulins and antisera TgG was prepared from Cohn Fraction II (American Red Cross, Bethesda, Md.) by DEAE-cellulose (Carl Schleicher & Schuell Co., Keen, N.H.) chromatography with 0.0175 M phosphate buffer, pH 6.3 [5]. IgA was prepared from myeloma sera by

Host and Environmental Factors Influencing Individual Human Cytokine Responses

“…IgA has been implicated with several age-related diseases such as macular degeneration and diabetes, which makes IgA a potential therapeutic agent for prophylaxis and/or treatment (Rodriguez-Segade et al, 1996; Yu et al, 2016). Higher IgA was also detected in men compared to women, as supported by earlier studies, while circulating concentrations of IgM were higher in women (Cassidy et al, 1974; Obiandu et al, 2013; Weber-Mzell et al, 2004). In another study from the HFGP (Aguirre-Gamboa et al, 2016), IgG2 and IgG4 are shown to significantly interact with age and gender, respectively.…”

Serum immunoglobulins and the risk of rheumatoid arthritis

“…It is well established that the occurrence of RA is dependent on age and sex,21 while serum immunoglobulin values are likewise age and sex dependent 22. Our matched case-control study designs, however, effectively eliminated the confounding influence of age and sex.…”

Age changes of human serum polyreactive immunoglobulins (PRIG) activity

“…If to calculate the average levels of serum IgG PRIG activity in these two groups of people, titers in aged people are approximately 3-4 times higher than in young ones. According to literature data [2][3][4], the concentration of IgG immunoglobulins may increase with age, but significantly less than the activity of serum IgG PRIG determined by us. The obtained data show that specific activity of IgG PRIG per unit of concentration of serum immunoglobulins also increases with age.…”

“…Significant deviations of serum immunoglobulins concentration from norm, as a rule, is the evidence for serious diseases [1][2][3][4].…”