Biological action of lantadene C, a new hepatotoxicant from <i>Lantana camara var. aculeata</i>

Sharma, Om P.; Vaid, J.; Pattabhi, Vasantha; Bhutani, K. K.

doi:10.1002/jbt.2570070204

Cited by 21 publications

(13 citation statements)

References 19 publications

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“…With regard to species vulnerability, lantana toxicity has been demonstrated in cattle, buffaloes, sheep and goats, rabbits, female rats, and guinea pigs (Sharma et al 1988). From non-ruminant group, it is guinea pig that exhibited the most typical symptoms comparable to experimental or field cases of lantana toxicosis in ruminants (Sharma et al 1992).…”

Section: Introductionmentioning

confidence: 98%

Sub-acute toxicity of lantadenes isolated from Lantana camara leaves in guinea pig animal model

et al. 2015

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The sub-acute toxicity of lantadenes isolated from Lantana camara leaves was studied in guinea pig laboratory animal model. A total of 20 guinea pigs of either sex were divided into five groups. Group I served as control, while groups II, III, IV, and V were orally administered lantadenes at the dose rate of 100, 50, 25, and 12.5 mg/kg body weight (bw), respectively for 28 days. The levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, acid phosphatase, total bilirubin, blood urea nitrogen, and creatinine were estimated in serum. The effect of lantadenes on lipid peroxidation, superoxide dismutase, reduced glutathione, and catalase was monitored in liver homogenate. The lantadenes at the dose rate of 25 mg/kg bw in animals of group IV did not result in mortality, produced gross and histopathological changes characteristic of sub-acute toxicity in liver and kidneys, and resulted in the highest levels of serum liver marker enzymes. Elevated lipid peroxidation levels and decreased levels of superoxide dismutase and catalase in group IV indicated free-radical-induced damage by lantadenes. It was concluded that lantadenes produced a dose-dependent toxicity and the dose level of 25 mg/kg bw was the sub-acute toxic dose which induced significant fibrosis and necrosis in liver of guinea pigs. To the best of our knowledge, this is the first report on the study of sub-acute toxicity of lantadenes in guinea pig animal model which mimic the actual livestock lantana toxicity cases in field conditions.

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Section: Introductionmentioning

confidence: 98%

Sub-acute toxicity of lantadenes isolated from Lantana camara leaves in guinea pig animal model

et al. 2015

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“…camara essential oil and leaves are composed of large amounts of sesquiterpene hydrocarbons, mainly β-caryophyllene [71], lantadene A, B and C which produce strong hepatotoxic response in rodents and the extracts have fumigant activity against Sitophilus granarius adults [72] [73]. Terpenoids, phenylpropanoids, and flavonoids are thought to be the main components which have biological activities in Lantana camara [60].…”

Section: Mode Of Action Of Some Active Ingredients From L Camaramentioning

confidence: 99%

The Toxicity, Persistence and Mode of Actions of Selected Botanical Pesticides in Africa against Insect Pests in Common Beans, <i>P. vulgaris</i>: A Review

Mpumi¹,

Mtei²,

Machunda³

et al. 2016

AJPS

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Common beans are affected by many insect pests such as bean leaf beetle, aphids, legume pod borer and bean beetles. Traditional and cultural practices such as site selection, crop rotation, intercropping and seed selection, sowing date are used to reduce the infestation of insect pests of common beans in the field and in storage rooms. Natural enemies such as predators, parasitoids and pathogens can control the insect pests. Synthetic pesticides such as cypermethion, carbaryl, and lambda-cyhalothrin have reported to be effective, but are toxic to people, destroy natural enemies and contaminate the environment. Botanical pesticides are the promising alternatives. This review paper explains toxicity, persistence and mode of actions of active ingredients of botanical pesticides. Rotenone from T. vogelii has the oral lethal dose (LD50) of 132 -1500 mg/kg to mammals. It delays the electron transport chain in mitochondria of the insects and limits the cellular energy production. Azadirachtin is antifeedant and growth disruptor of insects. It has low toxicity to mammals. The oral LD 50 in mammals is greater than 3540 mg/kg. Azadirachtin displays strong effects on chemoreceptors of the insects. Pyrethrins are axonic poisons and have repellent effects to insects. It is less toxic to mammals with the LD 50 of about 1500 mg/Kg. It attacks the nervous systems of insects. Sesquiterpene lactones from T. diversifolia, Pentacyclic triterpenoids from Lantana camara, Vernodalin, Vernodalol and Epivernodalol from V. amygdalina have repellent and feeding deterrents chemicals which discourage the insects from feeding the crop. Most active ingredients of botanical pesticides have short life span in the environment.

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“…Anti-hyperlipidemic Oleanolic acid and ursolic acid Hart et al, 1976b;Liu, 1995, Liu, 2005Mishra et al, 1997;Verma et al, 1997;Chen et al, 2005 (Lal & Kalra, 1960;Sharma et al, 1988b;Sharma et al, 2007). Guinea pigs show most typical signs of lantana toxicity (Sharma et al, 1988b), while male rats are often resistant to lantana toxicity because of the action of testosterones (Pass et al, 1979a;Pass et al, 1985;Sharma et al, 1992;Sharma et al, 2007). The toxic effects of lantana have been seen in Kangaroos and Ostriches also (Johnson & Jensen, 1998;Cooper, 2007).…”

Section: Toxic Components Of Lantana Camaramentioning

confidence: 99%

“…Liver: Swollen, fragile, pale yellow, mottled with rounded edges (Sharma et al, 1991(Sharma et al, , 1992. II.…”

Section: Clinical Signs (De Mello Et Al 2003; Sharma Et Al 2007)mentioning

confidence: 99%

Lantana camara: An alien weed, its impact on animal health and strategies to control

Kumar¹,

Katiyar²,

Kumar³

et al. 2016

JEBAS

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KEYWORDS Lantana camara Lantadenes Allelopathy Hepatotoxic Poisonous ABSTRACTLantana camara is one of the most commonly known noxious weed distributed worldwide. The red flower variety (L. camara var. aculeata) of this weed is mainly toxic and usually prevalent in tropical and sub-tropical countries. Lantana leads to hepatotoxicity, photosensitization and intrahepatic cholestasis almost in all the animals. LA is the main toxic pentacyclic triterpenoid present in this weed. Lantadene toxicity leads to fatty degeneration, bile duct hyperplasia, gall bladder edema, degeneration of parenchymal cells and portal fibrosis observed on histopathological examination. L. camara toxicity causes fluctuation in hematological as well as in biochemical parameters. The management of toxic effects can be achieved by activated charcoal, vaccination and supportive therapy but are not much effective. Besides the harmful effects of this plant, there are some beneficial effects also including antiinflammatory, hepatoprotective action, antitumor action etc. The control of this weed is difficult because of its allelopathic action. Nowadays this plant is used in many recent advanced techniques like phytoremediation of particulate pollution, phytoextraction of heavy metals and many others. Thereby the use of this plant in the field of research can be an effective way to manage this alien weed. As far as the toxicity is concerned it can be prevented by the using conventional therapeutic methods along with immunological, nanotechnological and biotechnological approaches. The aim of this article is to discuss the information regarding its progression, mechanism by which it affect animals, pathological alterations, treatment and what strategies we can opt to get rid of this weed.

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Biological action of lantadene C, a new hepatotoxicant from Lantana camara var. aculeata

Cited by 21 publications

References 19 publications

Sub-acute toxicity of lantadenes isolated from Lantana camara leaves in guinea pig animal model

Sub-acute toxicity of lantadenes isolated from Lantana camara leaves in guinea pig animal model

The Toxicity, Persistence and Mode of Actions of Selected Botanical Pesticides in Africa against Insect Pests in Common Beans, <i>P. vulgaris</i>: A Review

Lantana camara: An alien weed, its impact on animal health and strategies to control

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Biological action of lantadene C, a new hepatotoxicant from Lantana camara var. aculeata

Cited by 21 publications

References 19 publications

Sub-acute toxicity of lantadenes isolated from Lantana camara leaves in guinea pig animal model

Sub-acute toxicity of lantadenes isolated from Lantana camara leaves in guinea pig animal model

The Toxicity, Persistence and Mode of Actions of Selected Botanical Pesticides in Africa against Insect Pests in Common Beans, &lt;i&gt;P. vulgaris&lt;/i&gt;: A Review

Lantana camara: An alien weed, its impact on animal health and strategies to control

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The Toxicity, Persistence and Mode of Actions of Selected Botanical Pesticides in Africa against Insect Pests in Common Beans, <i>P. vulgaris</i>: A Review