Biological Activities and Volatile Constituents of Aegle marmelos (L.) Corrêa from Nepal

Satyal, Prabodh; Woods, Katherine E.; Dosoky, Noura S.; Neupane, Sanjaya; Setzer, William N.

doi:10.7275/r5q23x59

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…In most of the plants, the nematicidal activities were due to the presence of most potent phenolic compounds reported earlier . The essential oil present in the plants may also be responsible for enhanced antinematodal activity. , The phytochemical and GC–MS analyses of S. nigrum and M.…”

Section: Resultsmentioning

confidence: 86%

“…30 The essential oil present in the plants may also be responsible for enhanced antinematodal activity. 31,32 The phytochemical and GC−MS analyses of S. nigrum and M. arvensis confirmed that they contained all the potent phytochemicals and bioactive compounds responsible for nematicidal activities. 15,33−35 The detailed information is listed in Table 3 (phytochemicals) and Table 4 (chemical compounds).…”

Section: Antinematodal Potential Of Leaf Extracts Cmentioning

confidence: 89%

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Nematicidal Characterization of Solanum nigrum and Mentha arvensis Leaf Extracts Using Caenorhabditis elegans as a Model Organism

et al. 2023

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Considering foremost global issues instigated by parasitic nematodes, Solanum nigrum (S. nigrum) and Mentha arvensis (M. arvensis) nematicidal potential at the gene level has been explored herein. Methanol, ethyl acetate, chloroform, n-hexane, and distilled water were used for extract preparation. Caenorhabditis elegans (C. elegans) was used as the model organism. Nematicidal and anti-egg hatching assays, fluorescence microscopy, and quantitative real-time PCR were done. S. nigrum chloroform (LD 50 = 1.21 mg/mL) and M. arvensis methanol (LD 50 = 2.47 mg/mL) extracts exhibited excellent nematicidal potential. Both plants showed potent anti-egg hatching activity (1 mg/mL). S. nigrum methanol and M. arvensis ethyl acetate extracts showed high apoptotic effect in muscles, gonads, and uterus (eggs). Stress genes, that is, gst-4, hsp-16.2, and gpdh-1 were highly expressed in affected C. elegans (treated with S. nigrum and M. arvensis leaf extracts) when compared with normal C. elegans. Phytochemicals and bioactive compounds present in plants may be the major cause of their excellent nematicidal potential, which further confirmed that both plants could be an alternative candidate(s) for novel broad-scale anthelmintic drug(s).

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