Biological activities of Boesenbergia rotunda parts and extracting solvents in promoting osteogenic differentiation of pre-osteoblasts

Anti-Inflammatory and Antinociceptive Effects of Boesenbergia rotunda Polyphenol Extract in Diabetic Peripheral Neuropathic Rats

“…In this regard, B. rotunda a culinary and medicinal plant rich in polyphenolic constituents is widely used as a remedy for the treatment diabetes, rheumatic and muscle pain. 14 As such this study evaluated the ameliorative effects of B rotunda polyphenol extract against diabetes induced peripheral neuropathic pain.…”

“…B. rotunda is traditionally used in the treatment of fever, rheumatism, muscle pain, peptic ulcer, stomach disorders and bacterial infections. 14 , 15 Aside its folk use, B. rotunda have shown several bioactivities including biofilm formation inhibition, antiobesity, antioxidant, anticancer, antiviral, anti-inflammatory activities and in vitro antidiabetic activities. 16–18 Furthermore, B. rotunda is particularly rich in polyphenols notably chalcones and flavonoids, which are majorly responsible for its in vitro antidiabetic effects of the plant.…”

The protective effect of Boesenbergia rotunda extract on cisplatin-exposed human embryonic kidney-293 cells by inhibiting the expression of kidney injury molecule-1, neutrophil gelatinase associated-lipocalin, NF-κB, and caspases

“…Activation of caspases occurs approximately a half day after cisplatin treatment in vitro (5), and suppressing the activity of caspase reduced cisplatin-induced apoptosis (6,7). A previous study reported that Boesenbergia rotunda could stimulate the generation of osteoblast cells (8) and significantly increase pancreatic antioxidant enzyme activities (glutathione, superoxide dismutase, and catalase) (9). Considering the antioxidant property and the activity of B. rotunda in inducing cells growth, our present study aimed to investigate the cytotoxicity of cisplatin on human embryonic kidney-293 (HEK-293) cells and the protective impact of the ethanol extract of B. rotunda (EEBR) against such conditions by quantifying the expression of Kim-1, NGAL, nuclear factor-kappaB (NF-κB), caspase-3, and caspase-7 genes in cisplatin-exposed HEK-293 cells.…”

Physicochemical and biological properties of encapsulated Boesenbergia rotunda extract with different wall materials in enhancing antioxidant, mineralogenic and osteogenic activities of MC3T3-E1 cells

“…Especially, pinostrobin is a flavonoid well-known for biological or pharmacological activities, such as against-osteoporosis ( Gu et al, 2017 ), anti-oxidative, reducing estrogen, anti-inflammation, and induced cell proliferation ( Yusuf et al, 2013 ). Saah et al (2021) suggested that B. rotunda extract showed efficacy in enhancing cell proliferation and inducing MC3T3-E1 cell differentiation. However, the feasibility of B. rotunda extract use is limited, due to its low water solubility and instability under various types of stress (high temperature, light, oxygen, pH, enzymes, etc.).…”