Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Abstract

In recent years, several drugs have been developed deriving from traditional products and current drug research is actively investigating the possible therapeutic roles of many Ayruvedic and Traditional Indian medicinal therapies. Among those being investigated is Turmeric. Its most important active ingredient is curcuminoids. Curcuminoids are phenolic compounds commonly used as a spice, pigment and additive also utilized as a therapeutic agent used in several foods. Comprehensive research over the last century has revealed several important functions of curcuminoids. Various preclinical cell culture and animals studies suggest that curcuminoids have extensive biological activity as an antioxidant, neuroprotective, antitumor, anti-inflammatory, anti-acidogenic, radioprotective and arthritis. Different clinical trials also suggest a potential therapeutic role for curcuminoids in numerous chronic diseases such as colon cancer, lung cancer, breast cancer, inflammatory bowel diseases. The aim of this review is to summarize the chemistry, analog, metal complex, formulations of curcuminoids and their biological activities.

Antioxidant properties of curcuminoids isolated from Curcuma longa L.

“…As can be seen, the antioxidant potential of single curcuminoids is higher than curcuminoids in complexes with cyclodextrin and phospholipid, respectively. The antioxidant mechanism of curcumin was explained by the density functional theory with five different mechanisms including single electron transfer, radical adduct formation, H atom transfer from neutral curcumin, H atom transfer from deprotonated curcumin and sequential proton loss electron transfer (Amalraj et al, 2016). In our study, we did not observed an increase in the antioxidant activity of curcumin in complexes.…”

Eco-friendly synthesis of metal nanoparticles using ginger and garlic extracts as biocompatible novel antioxidant and antimicrobial agents

“…Nanoparticles containing antimicrobial and antioxidant substances could be considered as a new trend of antimicrobial therapeutic agents for the prevention and reduction of deterioration of food and pathogenic microorganisms [14,15].…”

Evaluation of Free Radical Scavenging Activity in Ethanolic Extract from Promising Accessions of Curcuma aeruginosa RoxB.

“…Curcuma aeruginosa RoxB. is a medicinal plant that contains phytochemical phenolic, flavonoid (Waras Nurcholis, Khumaida, Syukur, & Bintang, 2016b) and curcuminoids (Bos et al, 2007;Waras Nurcholis, Khumaida, Syukur, & Bintang, 2016a), so it's a potential source of natural antioxidant (Amalraj, Pius, Gopi, & Gopi, 2017;W Nurcholis, Khumaida, Syukur, Bintang, & Ardyani, 2015). C. aeruginosa has a broad geographical scope in Indonesia, which necessitates extensive investigation on the antioxidant attributes of their different accessions.…”