Biological Activities of Extracts from Different Parts of two Cultivars of Prunus persica ‘Akatsuki’ and ‘Fastigiata’

Abstract

We investigated the antioxidant, anti-lipase and anti-dementia activities of peach (Prunus persica (L.) Batsch) fruit and its by-products. The ethanol extracts of branch showed relatively high activity in all biological activities. Then, the extract was fractionated, and eight compounds were isolated from the ethyl acetate fraction. Results showed 4,2',4'-trihydroxy-6'-methoxychalcone 4'-O-β-D-glucopyranoside (5) and quercetin 3-O-β-D-glucopyranoside (7) as newly identified compounds in P. persica. From the biological investigation, it was considered that quercetin 3-O-β-D-glucopyranoside (7) was the main active compound of antioxidant activity. The main active compound of anti-lipase activity in these was oleanolic acid (1). In addition, (+)-4'-O-methylcatechin (4), 4,2',4'trihydroxy-6'-methoxychalcone 4'-O-β-D-glucopyranoside (5) and ferulic acid (6) were the main active compounds of anti-dementia activity with acetylcholinesterase inhibitory assay. The results obtained suggested that these active compounds from peach branches of P. persica could be exploited as natural antioxidants, anti-lipase and anti-dementia materials in the future.

GC-MS Metabolic Profile and α-Glucosidase-, α-Amylase-, Lipase-, and Acetylcholinesterase-Inhibitory Activities of Eight Peach Varieties

“…Although it was thought that phenolic compounds are responsible for the inhibitory activity towards this enzyme [ 89 ], Rodríguez-Solana et al [ 91 ] reported a negative correlation (according to Pearson correlation coefficients) in carob liqueurs. Nakagawa et al [ 92 ] found no inhibitory activity of extracts of the peel and flesh of unripe fruits of “Akatsuki” and “Fastigiata” peach varieties. It could be suggested that the presence of caffeic and chlorogenic acids contribute to the AChE-inhibitory activity of the extracts, as both phenolic acids exhibit neuroprotective properties.…”

Anin silicoperception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

“…The total ethanolic extract of Prunus persica L. fruits afforded 3 0hydroxy-4 0 -methoxy-chroman-7-O-b-D-glucopyranoside 4, and it is the rst time it has been isolated from a natural source, together with three known compounds, ferulic acid heptyl ester 1, 37 naringenin 2, 38 and 4,2 35 as shown in Fig. 3.…”

“…33 The fruit is also involved in different biological activities, such as growth-inhibition activity against different breast cell lines, 34 antioxidant, anti-lipase, and anti-dementia activities. 35 Recently, Traditional Chinese Medicine (TCM) has recommended peach, under the Chinese name "Taoren", as a contributor in the prevention and treatment of COVID-19, 36 that evoked us to carry out this study.…”

“…Hz, H-5 0 ), and d H 6.9 (1H, dd, J ¼ 2.4, 8.4 Hz, H-6 0 ) indicated the presence of 3 0 and 4 0 di-substitution in the B ring. 35,40 The remaining three aromatic protons at d H 7.3 (1H, d, J ¼ 8.4 Hz), d H 6.8 (1H, dd, J ¼ 2.4, 8.4 Hz), and d H 6.4 (1H, d, J ¼ 2.4 Hz) were assigned to H-5, H-6, and H-8, respectively. 41 Also, the 1 H-NMR spectrum showed an anomeric proton signal at d H 4.7 (1H, d, J ¼ 7.8 Hz, H-1 00 ), which indicated the b-conguration of the glucose moiety.…”

“…Different applications of ROCS can be applied, such as virtual screening, lead hopping, molecular alignment, pose generation, and structural predictions. 34,35,37 This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.…”