2009
DOI: 10.1517/13543770903216675
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Biological activities of guanidine compounds

Abstract: Recent achievements in the synthesis of guanidine-containing molecules with diverse chemical, biochemical and pharmacological properties make them of great importance to the design and development of novel drugs acting at CNS, anti-inflammatory agents, inhibitors of Na(+)/H(+) exchanger, inhibitors of NO synthase, antithrombotic, antidiabetic and chemotherapeutic agents as well as guanidinium-based transporters and vectors.

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Cited by 138 publications
(101 citation statements)
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“…Guanidine and guanidinium moieties are the constituents of various naturally occurring and artificial biologically active compounds [6,7]. Owing to their delocalized nature (6π electrons in a conjugated planar system), they have also found applications in material science, particularly in the design of non-linear optical materials [5,[8][9][10] and molecular sensors [11][12][13].…”
Section: Commentmentioning
confidence: 99%
“…Guanidine and guanidinium moieties are the constituents of various naturally occurring and artificial biologically active compounds [6,7]. Owing to their delocalized nature (6π electrons in a conjugated planar system), they have also found applications in material science, particularly in the design of non-linear optical materials [5,[8][9][10] and molecular sensors [11][12][13].…”
Section: Commentmentioning
confidence: 99%
“…12,13 The guanidine group possesses chemical and physicochemical properties relevant for many compounds of medicinal interest and guanidine-containing derivatives constitute an important class of therapeutic agents suitable for the treatment of a wide spectrum of diseases. 14 target AD as b-secretase (BACE-1) inhibitors (compounds 3 and 4, Fig. 1).…”
Section: Introductionmentioning
confidence: 99%
“…/H ? exchanger, inhibitors of NO synthase, and antithrombotic and antidiabetic agents (Saczewski and Balewski, 2009). The guanidine is recognized as the functional group that could specifically recognize diverse protein, DNA, and RNA targets by virtue of potential electrostatic and hydrogen-bonding interactions.…”
Section: Introductionmentioning
confidence: 99%