Biological activities of juvenile hormone III skipped bisepoxide in last instar nymphs and adults of a stink bug, Plautia stali

Kotaki, Toyomi; Shinada, Tetsuro; Kaihara, Kanako; Ohfune, Yasufumi; Numata, Hideharu

doi:10.1016/j.jinsphys.2010.10.003

Cited by 52 publications

(34 citation statements)

References 25 publications

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“…However, the structure of JH in the suborder Heteroptera has remained uncertain in spite of attempts to identify it [7][8][9][10][11][12][13]. Recently, we identified the structure of JH in a stink bug, Plautia stali, and named it juvenile hormone III skipped bisepoxide (JHSB 3 ) and demonstrated its biological function as the JH in this stink bug [14,15]. Here we review the process of structure determination of JHSB 3 and its biological function as JH in P. stali.…”

Section: Introductionmentioning

confidence: 99%

Structure Determination of a Natural Juvenile Hormone Isolated from a Heteropteran Insect

Kotaki

Shinada

Numata

2012

Psyche: A Journal of Entomology

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Juvenile hormone (JH), which occurs in several forms in different insects, is one of the most important insect hormones. The structure of JH in Heteroptera has not been elucidated until recently, although insects in this suborder have long been used as experimental animals for JH research. Here we review the structure determination of a novel JH in a stink bug,Plautia stali, which was named juvenile hormone III skipped bisepoxide [JHSB3: methyl (2R,3S,10R)-2,3;10,11-bisepoxyfarnesoate], based on the arrangement of two epoxides at C2,3 and C10,11 with a skipped double bond at C6,7.

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Section: Introductionmentioning

confidence: 99%

Structure Determination of a Natural Juvenile Hormone Isolated from a Heteropteran Insect

Kotaki

Shinada

Numata

2012

Psyche: A Journal of Entomology

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“…Juvenile hormone III, the homolog found in most insects, was described in 1973 from the moth Manduca sexta 7 . Finally, two double-epoxidated compounds were later reported, JH III bisepoxide (JHB3) in Drosophila melanogaster 8 , and JH III skipped bisepoxide (JHSB3) in the heteropteran Plautia stali 9,10 . open Scientific RepoRtS | (2020) 10:3091 | https://doi.…”

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confidence: 99%

The juvenile hormone described in Rhodnius prolixus by Wigglesworth is juvenile hormone III skipped bisepoxide

Villalobos-Sambucaro

Nouzová

Ramírez

et al. 2020

Sci Rep

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Juvenile hormones (JHs) are sesquiterpenoids synthesized by the corpora allata (CA). They play critical roles during insect development and reproduction. The first JH was described in 1934 as a "metamorphosis inhibitory hormone" in Rhodnius prolixus by Sir Vincent B. Wigglesworth. Remarkably, in spite of the importance of R. prolixus as vectors of Chagas disease and model organisms in insect physiology, the original JH that Wigglesworth described for the kissing-bug R. prolixus remained unidentified. We employed liquid chromatography mass spectrometry to search for the JH homologs present in the hemolymph of fourth instar nymphs of R. prolixus. Wigglesworth's original JH is the JH III skipped bisepoxide (JHSB3), a homolog identified in other heteropteran species. Changes in the titer of JHSB3 were studied during the 10-day long molting cycle of 4 th instar nymph, between a blood meal and the ecdysis to 5 th instar. In addition we measured the changes of mRNA levels in the CA for the 13 enzymes of the JH biosynthetic pathway during the molting cycle of 4 th instar. Almost 90 years after the first descriptions of the role of JH in insects, this study finally reveals that the specific JH homolog responsible for Wigglesworth's original observations is JHSB3.Sir Vincent B. Wigglesworth, the famous British insect endocrinologist, published a series of three classical manuscripts in the years 1934, 1936 and 1940 that described the existence of an "inhibitory hormone" that prevented metamorphosis in the early nymphal stages of the blood-sucking bug Rhodnius prolixus 1-3 . The manuscripts contained a series of elegant studies, including a parabiosis techniques that allowed the mixing of the hemolymph of fourth and fifth instar nymphs, as well as corpora allata (CA) transplantation experiments. These studies permitted Wigglesworth to demonstrate for the first time the existence of an "inhibitory hormone" secreted by the CA and delivered to target tissues by the hemolymph. In his latest article, Wigglesworth proposed for the first time to name the "inhibitory hormone" as "juvenile hormone" (JH) 3 . Wigglesworth also used transplantation and parabiosis experiments to reveal that the CA of the 4 th instar nymphs of R. prolixus was an equally good source of a "yolk-forming hormone", whereas the CA of a 5 th instar nymph was ineffective. He concluded that only a single hormone, the "Juvenile Hormone", was responsible for both actions, the inhibition of metamorphosis, as well as the control of development of the reproductive organs in the adult 4 .After the pioneering studies by Wigglesworth and others, the chemical nature of JH remained unidentified until the late 1960's. The first two JHs, named JH I and II, were isolated from the moth Hyalophora cecropia. They were identified as sesquiterpenes, with a methyl ester (α, β-unsaturated) at the C1 position and an epoxide ring at the C10-C11 position 5,6 . Juvenile hormone III, the homolog found in most insects, was described in 1973 from the moth Manduca sexta 7 . Finally, two dou...

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“…Treatment with JHSB 3 at the beginning of the starvation period also nullifies the oosorption‐inducing effect of food deprivation in a dose‐dependent fashion. With respect to ovary development, JHSB 3 treatment likely substitutes the role of CC‐CA in females whose CC‐CA was removed (Kotaki et al , ), despite the CC being a neurohaemal organ, which may release neuropeptides having regulatory roles in JH biosynthesis and reproduction. The results of the present study suggest that a low JH titre is a key hormonal trigger for the induction of oosorption, and that a lack of nutrients or a reduced protein content in the haemolymph is less likely to exert a direct effect on the ovary tissue to trigger oosorption.…”

Section: Discussionmentioning

confidence: 99%

Oosorption in the stink bug Plautia stali: role of Juvenile hormone in the induction of oosorption

et al. 2016

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To clarify the role of Juvenile hormone (JH) in the induction of oosorption in females of the stink bug Plautia stali Scott (Heteroptera: Pentatomidae), the effects of extirpation and implantation of the corpus cardiac‐corpus allatum complex (CC‐CA) are examined in fed and starved adults, respectively. Removal of CC‐CA induces oosorption in fed females, whereas CC‐CA implantation stimulates ovary development in starved females. Transection of the nervous connections between the brain and CC‐CA also exerts a stimulatory effect on ovary development. Uptake of yolk protein by the oocytes, assessed in terms of incorporation of a fluorescence dye, occurs on the day after food deprivation but ceases within 1 day after allatectomy. When females are deprived of food, beginning on day 3 of adult life, and treated with JH III skipped bisepoxide (JHSB3) on the same day, their ovaries develop in a dose‐dependent fashion. Approximately half of the starved females that received JHSB3 application on day 5 undergo oosorption in the terminal oocytes. This indicates that the critical starvation period for oosorption induction is approximately 2 days, and the earlier half of this period may reflect the time required for the brain to detect poor nutritional condition. During the latter half, in response to food deprivation, the brain inhibits JH biosynthesis by the corpus allatum through nervous connections, resulting in a low JH titre, which in turn induces oosorption.

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Biological activities of juvenile hormone III skipped bisepoxide in last instar nymphs and adults of a stink bug, Plautia stali

Cited by 52 publications

References 25 publications

Structure Determination of a Natural Juvenile Hormone Isolated from a Heteropteran Insect

Structure Determination of a Natural Juvenile Hormone Isolated from a Heteropteran Insect

The juvenile hormone described in Rhodnius prolixus by Wigglesworth is juvenile hormone III skipped bisepoxide

Oosorption in the stink bug Plautia stali: role of Juvenile hormone in the induction of oosorption

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