Biological Activities of Nanoparticles and Mechanism of Action

Chaudhary, Karan; Masram, Dhanraj T.

doi:10.1007/978-981-15-1702-0_2

Cited by 13 publications

(8 citation statements)

References 56 publications

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“…In addition to the above-mentioned mechanisms of action, the accumulation of NPs at the diseased site causes (Roy et al, 2019;Barabadi et al, 2020;Chaudhary et al, 2020). Moreover, the accumulation of NPs at the diseased site demonstrates the diagnostic potential because NPs can act as potential contrast agents for X-ray (gold NPs), magnetic resonance imaging (MRI) (magnetic NPs), computed tomography (CT) and MRI (hybrid NPs from iron oxide and gold) (Smith et al, 2012).…”

Section: Nanodrugs In Cancer Therapymentioning

confidence: 99%

“…In addition to the above-mentioned mechanisms of action, the accumulation of NPs at the diseased site causes mitochondria damage and dysfunction, upregulation of apoptotic factors, DNA fragmentation, membrane damage of cancer cells, oxidation of enzymes and proteins, protein denaturation, disassembly of ribosomes, generation of reactive oxygen species (ROS), interruption of electron transport ( Roy et al, 2019 ; Barabadi et al, 2020 ; Chaudhary et al, 2020 ). Moreover, the accumulation of NPs at the diseased site demonstrates the diagnostic potential because NPs can act as potential contrast agents for X-ray (gold NPs), magnetic resonance imaging (MRI) (magnetic NPs), computed tomography (CT) and MRI (hybrid NPs from iron oxide and gold) ( Smith et al, 2012 ).…”

Section: Tumor Cells Targeting By Nanoparticlesmentioning

confidence: 99%

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Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management—Targeting cancer stem cells in the framework of predictive, preventive, personalized medicine

et al. 2023

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Cancer causes many deaths worldwide each year, especially due to tumor heterogeneity leading to disease progression and treatment failure. Targeted treatment of heterogeneous population of cells - cancer stem cells is still an issue in protecting affected individuals against associated multidrug resistance and disease progression. Nanotherapeutic agents have the potential to go beyond state-of-the-art approaches in overall cancer management. Specially assembled nanoparticles act as carriers for targeted drug delivery. Several nanodrugs have already been approved by the US Food and Drug Administration (FDA) for treating different cancer types. Phytochemicals isolated from plants demonstrate considerable potential for nanomedical applications in oncology thanks to their antioxidant, anti-inflammatory, anti-proliferative, and other health benefits. Phytochemical-based NPs can enhance anticancer therapeutic effects, improve cellular uptake of therapeutic agents, and mitigate the side effects of toxic anticancer treatments. Per evidence, phytochemical-based NPs can specifically target CSCs decreasing risks of tumor relapse and metastatic disease manifestation. Therefore, this review focuses on current outlook of phytochemical-based NPs and their potential targeting CSCs in cancer research studies and their consideration in the framework of predictive, preventive, and personalized medicine (3PM).

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Section: Nanodrugs In Cancer Therapymentioning

confidence: 99%

Section: Tumor Cells Targeting By Nanoparticlesmentioning

confidence: 99%

Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management—Targeting cancer stem cells in the framework of predictive, preventive, personalized medicine

et al. 2023

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“… 105 Mechanisms of NPs’ antimicrobial activity include direct interaction with microbial membrane and cell wall, induction of the host’s innate and adaptive immune responses, reactive oxygen species generation, dispersion of microbial biofilms, QS inhibition, efflux inhibition and plasmid curing. 106 , 107 Numerous reports have been published on the efficacy of nAbts in the treatment of MDR pathogens. 108–111 For instance, Yang and colleagues 112 reported the synthesis of broad-spectrum biodegradable polycarbonates with the potential for targeting intercellular pathogens such as Mycobacteria tuberculosis , which causes TB.…”

Section: Chemically Synthesized Nanoantibiotics (Nabts)mentioning

confidence: 99%

Antimicrobial resistance expansion in pathogens: a review of current mitigation strategies and advances towards innovative therapy

Adefisoye,

Olaniran

2023

JAC-Antimicrobial Resistance

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The escalating problem of antimicrobial resistance (AMR) proliferation in clinically important pathogens has become one of the biggest threats to human health and the global economy. Previous studies have estimated AMR-associated deaths and disability-adjusted life-years (DALYs) in many countries with a view to presenting a clearer picture of the global burden of AMR-related diseases. Recently, several novel strategies have been advanced to combat resistance spread. These include efflux activity inhibition, closing of mutant selection window (MSW), biofilm disruption, lytic bacteriophage particles, nanoantibiotics, engineered antimicrobial peptides, and the CRISPR-Cas9 gene-editing technique. The single or integrated deployment of these strategies has shown potentialities towards mitigating resistance and contributing to valuable therapeutic outcomes. Correspondingly, the new paradigm of personalized medicine demands innovative interventions such as improved and accurate point-of-care diagnosis and treatment to curtail AMR. The CRISPR-Cas system is a novel and highly promising nucleic acid detection and manipulating technology with the potential for application in the control of AMR. This review thus considers the specifics of some of the AMR-mitigating strategies, while noting their drawbacks, and discusses the advances in the CRISPR-based technology as an important point-of-care tool for tracking and curbing AMR in our fight against a looming ‘post-antibiotic’ era.

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“…Keeping this perspective in mind, this is the first time we reported bioinspired C. viviparum -assisted δ-Bi 2 O 3 NPs ( Figure 1 ) for visible-light-driven photocatalytic degradation of toxic dyes. Also, δ-Bi 2 O 3 NPs have been widely applied for biological activities; 40 therefore, to evaluate δ-Bi 2 O 3 NPs for biological functions, molecular docking investigation has been performed on protein crystal structure (NDM-1) PDB ID 5XP9 having natural inhibitor Bi+++(ligand BS3). It was found that Bi (III) exerts anti-MBL activity in vitro and also it had good interaction with amino acid residues 512 THR, 82 GLN,189 VAL, 121 THR,131 LEU,192 VAL, 91GLN, 82ILE111 SER,199 LEV, 142VAL, and 143 ALA, all having a hydrogen-bonding distance of about 2.0 Å, showing good interaction property with the best ligand pose energy of −3.851 kcal/mole.…”

Section: Introductionmentioning

confidence: 99%

Biosynthesized δ-Bi₂O₃ Nanoparticles from Crinum viviparum Flower Extract for Photocatalytic Dye Degradation and Molecular Docking

Chouke

Dadure²,

Potbhare

et al. 2022

ACS Omega

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Bioinspired delta-bismuth oxide nanoparticles (δ-Bi 2 O 3 NPs) have been synthesized using a greener reducing agent and surfactant via co-precipitation method. The originality of this work is the use of Crinum viviparum flower extract for the first time for the fabrication of NPs, which were further calcined at 800 °C to obtain δ-Bi 2 O 3 NPs. Physicochemical studies such as FTIR spectroscopy and XPS confirmed the formation of Bi 2 O 3 NPs, whereas XRD and Raman verified the formation of the cubic delta (δ) phase of Bi 2 O 3 NPs. However, HRTEM revealed the spherical shape with diameter 10–20 nm, while BET studies expose mesoporous nature with a surface area of 71 m 2 /gm. The band gap for δ-Bi 2 O 3 NPs was estimated to be 3.45 eV, which ensured δ-Bi 2 O 3 to be a promising photocatalyst under visible-light irradiation. Therefore, based on the results of physicochemical studies, the bioinspired δ-Bi 2 O 3 NPs were explored as active photocatalysts for the degradation of toxic dyes, viz ., Thymol blue (TB) and Congo red (CR) under visible-light irradiation. The study showed 98.26% degradation of TB in 40 min and 69.67% degradation of CR in 80 min by δ-Bi 2 O 3 NPs. The photogenerated holes and electrons were found responsible for this enhancement. Furthermore, molecular docking investigations were also performed for δ-Bi 2 O 3 NPs to understand its biological function as New Delhi metallo-β-lactamase 1 (NDM-1) [PDB ID 5XP9 ] enzyme inhibitor, and studies revealed good interaction with various amino acid residues and found good hydrogen bonding with a fine pose energy of −3.851 kcal/mole.

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Biological Activities of Nanoparticles and Mechanism of Action

Cited by 13 publications

References 56 publications

Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management—Targeting cancer stem cells in the framework of predictive, preventive, personalized medicine

Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management—Targeting cancer stem cells in the framework of predictive, preventive, personalized medicine

Antimicrobial resistance expansion in pathogens: a review of current mitigation strategies and advances towards innovative therapy

Biosynthesized δ-Bi₂O₃ Nanoparticles from Crinum viviparum Flower Extract for Photocatalytic Dye Degradation and Molecular Docking

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Biological Activities of Nanoparticles and Mechanism of Action

Cited by 13 publications

References 56 publications

Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management—Targeting cancer stem cells in the framework of predictive, preventive, personalized medicine

Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management—Targeting cancer stem cells in the framework of predictive, preventive, personalized medicine

Antimicrobial resistance expansion in pathogens: a review of current mitigation strategies and advances towards innovative therapy

Biosynthesized δ-Bi2O3 Nanoparticles from Crinum viviparum Flower Extract for Photocatalytic Dye Degradation and Molecular Docking

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Product

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Biosynthesized δ-Bi₂O₃ Nanoparticles from Crinum viviparum Flower Extract for Photocatalytic Dye Degradation and Molecular Docking