Biological Activities of Pyrazoline Derivatives -A Recent Development

Abstract

Pyrazolines are well known and important nitrogen containing 5-membered heterocyclic compounds and various methods have been worked out for their synthesis. Numerous pyrazoline derivatives have been found to possess considerable biological activities, which stimulated the research activity in this field. They have several prominent effects, such as antimicrobial, antimycobacterial, antifungal, antiamoebic, anti-inflammatory, analgesic, antidepressant and anticancer activities. They also possess some potent receptor selective biological activity like Nitric oxide synthase (NOS) inhibitor and Cannabinoid CB1 receptor antagonists activity. 4,5-dihydro-1H- pyrazolines seem to be the most frequently studied pyrazoline type compounds. As a result, a large number of such pyrazolines using different synthetic methods for their preparation have been described in the chemistry literature. The present review provides an insight view to pyrazolines synthesis and its biological activities along with the compilation of recent patents on pyrazolines.

Energy Based Pharmacophore Modelling and Docking Studies for Determining Potent Inhibitor Against M2 Proton Channel of Influenza Virus

“…64 In another two studies conducted individually it was observed that pyrazoline derivatives derived from phenoxy acetic acid had higher anti-viral activity against a broad panel of viruses in different cell cultures. 65,66,67 Another such constituent structure having anti-viral activity was diphenylmethane of Progabide (DB00837). Intriguingly, diphenylmethane and its derivatives are active against a host of viral infections like Bovine-viral diarrhoea virus, A-PR8 virus, poliomyelitis virus, adenovirus, vaccinia virus and MHV3 virus.…”

Crystal structure of 5-(2-chloro-5-nitrophenyl)-3-(4-chlorophenyl)-N-ethyl-4,5-dihydro-1H-pyrazole-1-carbothioamide, C18H16Cl2N4O2S

“…They have signi cant biological activities including antimicrobial, anticonvulsant and antiviral [5][6][7][8][9]. The asymmetric unit of the title structure contains one molecule, in which the phenyl ring (C10-C15) is highly deviated from the whole molecule plane and makes a dihedral angle of 78.74(3)°with the pyrazol ring (N1-N2-C7-C8-C9).…”

Synthesis of 1-phenyl-3-(4’-nitrophenyl)-5-(3’,4’-dimethoxy-6’-nitrophenyl)-2-pyrazoline and its antibacterial activity

“…Signal 7 which splitted as triplet predicted as proton of aromatic ring 3 in C 3 which had two protons neighbor. Proton 7 and 8 that had integration of 2 protons were protons from aromatic ring 3 . From 1 H-NMR spectra, it could be said that pyrazoline has been formed.…”

“…Pyrazole and pyrazoline are important nitrogen containing 5-membered heterocyclic compound. Pyrazoline which is well known as pyrazole derivative or 4,5-dihydropyrazole is reported possess a broad spectrum of biological activities such as anticonvulsant [2], antimicrobial [1,3,8], antiamoebic [3], analgesic [1], anti-inflammmatory [1], antidepressant [4], anxiogenic [4], inhibitors of monoamine oxidase [4], fungisical [5], insecticidal [5], antitumor [6], and antinociceptive [7]. Therefore, the prevalence of pyrazole core in biologically active molecules has stimulated the need for elegant and efficient ways to make these heterocyclic lead.…”