Biological activity of Guatteria cardoniana fractions

Arulselvan

JOURNAL OF HEALTH SCIENCE

et al. 2006

175

The present study was aimed to evaluate the anti-diabetic potential of Terminalia chebula (T. chebula) fruits on streptozotocin (STZ)-induced experimental diabetes in rats. Oral administration of ethanolic extract of the fruits (200 mg/kg body weight/rat/day) for 30 days significantly reduced the levels of blood glucose and glycosylated hemoglobin in diabetic rats. Determination of plasma insulin levels revealed the insulin stimulating action of the fruit extract. Also, the alterations observed in the activities of carbohydrate and glycogen metabolising enzymes were reverted back to near normal after 30 days of treatment with the extract. Electron microscopic studies showed significant morphological changes in the mitochondria and endoplasmic reticulum of pancreatic β cells of STZinduced diabetic rats. Also, a decrease in the number of secretory granules of β-cells was observed in the STZinduced diabetic rats and a these pathological abnormalities were normalized after treatment with T. chebula extract. The efficacy of the fruit extract was comparable with glibenclamide, a well known hypoglycemic drug.

Section: Discussionmentioning

confidence: 99%

Anti-Diabetic Activity of Fruits of Terminalia chebula on Streptozotocin Induced Diabetic Rats

Arulselvan

JOURNAL OF HEALTH SCIENCE

et al. 2006

175

“…Streptozotocin induces irreversible destruction of pancreatic b-cells, causing degranulation and reduction of insulin secretion (Junod et al, 1969). Glibenclamide is often used as a standard antidiabetic drug in streptozotocin-induced moderate diabetes to compare efficacy of a variety of hypoglycemic agents (Paredes et al, 2001). Preliminary studies revealed the nontoxic nature of the fruit extract.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antioxidant Potential ofTerminalia chebula. Fruits Studied in Streptozotocin-Induced Diabetic Rats

Senthilkumar

Subramanian

2007

Pharmaceutical Biology

Oxidative stress is believed to be a pathogenic factor in the development of diabetic complications. Recently, we have reported the antidiabetic activity of Terminalia chebula Retz. (Combretaceae) fruits on streptozotocin (STZ)-induced experimental diabetes. The current study was aimed to evaluate the antioxidant potential of Terminalia chebula fruits on STZ-induced diabetic rats. Oral administration of ethanol extract of Terminalia chebula fruit at a concentration of 200 mg=kg body weight for 30 days significantly controlled the alteration in the levels of thiobarbituric acid reactive substances, hydroperoxides, and both enzymatic and nonenzymatic antioxidants. In addition, the treatment also resulted in a significant decrease in the levels of blood glucose and glycosylated hemoglobin. The results are comparable with glibenclamide, a known hypoglycemic drug. The presence of biologically active ingredients in the fruit extract may be responsible for the antioxidant properties of the Terminalia chebula fruits, which in turn may be partially responsible for its antidiabetogenic properties.

“…A variety of herbal (medicinal) preparations have shown potentials for inhibiting viruses causing serious infections among humans such as measles viruses (Olila et al, 2002;Sindambiwe et al, 1999), human rotaviruses (HRV) (Husson et al, 1994;Takahashi et al, 2001), respiratory syncytial virus (RSV), human rhinoviruses (Glatthaar-Saalmuller et al, 2001), coxsackie group of viruses (Evstropov et al, 2004;Su et al, 2006), neurotropic Sindbis virus (NSV) (Paredes et al, 2001) and various strains of poliovirus (Andrighetti-Frohner et al, 2005;Melo et al, 2006;Vilagines et al, 1985). To prove/disprove antiviral effect of any herbal preparation it is essential to molecularly dissect its effects.…”

Section: Medicinal Plants In Miscellaneous Viral Infectionsmentioning

confidence: 99%

Antiviral potentials of medicinal plants

et al. 2008

Medicinal plants have been widely used to treat a variety of infectious and non-infectious ailments. According to one estimate, 25% of the commonly used medicines contain compounds isolated from plants. Several plants could offer a rich reserve for drug discovery of infectious diseases, particularly in an era when the latest separation techniques are available on one hand, and the human population is challenged by a number of emerging infectious diseases on the other hand. Among several other ailments, viral infections, particularly infections associated with human immunodeficiency virus type 1 (HIV-1) and 2 (HIV-2), and newly emerging infectious viruses have challenged mankind survival. Of importance, a variety of medicinal plants have shown promise to treat a number of viral infections, and some of them possess broad-spectrum antiviral activity. In the past, exploration into the antiviral activity of various promising medicinal plants was limited due to: (a) highly infectious nature of viruses and (b) lack of appropriate separation techniques for the identification of antiviral components from plants. Development of vector-based strategies, in which non-infectious molecular clone of a virus could be used for antiviral screening purposes, and advancement in separation technologies offers promise for medicinal plants usage in modern drug discovery. This article describes potential antiviral properties of medicinal plants against a diverse group of viruses, and suggests screening the potential of plants possessing broad-spectrum antiviral effects against emerging viral infections.