Biological activity of <i>Stevia rebaudiana</i> Bertoni and their relationship to health

Ruíz-Ruíz, Jorge Carlos; Moguel-Ordóñez, Yolanda; Campos, Maira Rubí Segura

doi:10.1080/10408398.2015.1072083

Cited by 99 publications

(69 citation statements)

References 52 publications

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“…In agreement with these results, we demonstrated a significant reduction in the activities of SID, CAT and GPx in the present study, with a significant increase in lipid peroxidation marker (MDA). Also, many authors have reported the direct antioxidant activity of extracts from the leaves of Stevia rebaudiana Bertoni, owing to the presence of alkaloids, flavonoids, and polyphenols (Ruiz-Ruiz et al, 2017). In the present study, we demonstrated that Stevia extract, stevioside and chlorogenic acid caused a significant increase in the activities of SOD, CAT and Gpx, together with a significant reduction in lipid peroxidation (MDA) in soleus muscle.…”

Section: Discussionsupporting

confidence: 67%

Attenuation of metabolic dysfunctions in the skeletal muscles of type 1 diabetic rats by Stevia rebaudiana extracts, via AMPK upregulation and antioxidant activities [pdf]

El-Mesallamy¹,

Mahmoud²,

Elazab³

et al. 2018

Acta Sci Pol Technol Aliment

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Section: Discussionsupporting

confidence: 67%

Attenuation of metabolic dysfunctions in the skeletal muscles of type 1 diabetic rats by Stevia rebaudiana extracts, via AMPK upregulation and antioxidant activities [pdf]

El-Mesallamy¹,

Mahmoud²,

Elazab³

et al. 2018

Acta Sci Pol Technol Aliment

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“…Los esteviósidos se han catalogado como agentes antioxidantes, antiinflamatorios, antihipertensivos y reguladores de niveles de glucosa en sangre (55,56). Las investigaciones en el 2015 afirmaban que el consumo de este edulcorante no presentaba ningún riesgo para la salud, aun en combinación con otros fármacos como la metformina (57).…”

Section: Edulcorantes Naturalesunclassified

Consumo de edulcorantes no nutritivos: efectos a nivel celular y metabólico

Stephens-Camacho

Valdez-Hurtado

Lastra-Zavala

et al. 2018

Perspect Nutr Humana

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ResumenAntecedentes: la función principal de los edulcorantes no nutritivos es proveer al consumidor un producto dulce sin la carga calórica del azúcar. El consumo de edulcorantes no nutritivos se relaciona con alteraciones en el ADN, con apoptosis y con la síntesis de precursores de cáncer. Además, su consumo también se relaciona recientemente con un incremento de tejido adiposo. Objetivo: analizar el efecto de los edulcorantes no nutritivos a largo plazo, evaluando el riesgo de estos compuestos. Materiales y métodos: búsqueda en bases de datos, PubMed, SciELO y Redalyc, y análisis de bibliografía relacionada con efectos tóxicos y metabólicos del consumo de edulcorantes no nutritivos. Resultados: el consumo de estos edulcorantes presentó efectos citotóxicos en diferentes modelos de estudio. Parece existir una relación con el incremento en la síntesis de tejido adiposo, que provoca obesidad y enfermedades derivadas. Los edulcorantes sintéticos fueron los que presentaron más alteraciones citotóxicas, mientras que edulcorantes naturales, a excepción de los esteviósidos, no presentaron efectos adversos. Múltiples investigaciones explican el efecto del consumo de estos edulcorantes en el metabolismo y los efectos citotóxicos. Conclusiones: el tema de edulcorantes es controversial, por ello la información recopilada en esta revisión busca proporcionar un panorama que ayude a comprender la respuesta a nivel celular y metabólico sobre su consumo.Palabras clave: edulcorante no nutritivo, edulcorante, toxicidad, efectos adversos, diabetes mellitus. AbstractBackground: The primary function of non-nutritive sweeteners is to provide the consumer with a sweet product without the caloric load of sugar. The consumption of non-nutritive sweeteners is related to alterations in DNA, apoptosis, and the synthesis of cancer precursors. Recently, its consumption has been related to an increase in adipose tissue. Objective: To analyze the effect of long-term consumption of these sweeteners and evaluate the risk of these related factors. Materials and Methods: Pubmed, Scielo and Redalyc database search and analysis of references related to toxic and metabolic effects of consumption of non-nutritrive sweeteners. Results: The consumption presents cytotoxic effects in different study models. There appears to be a relationship with an increase in synthesis of adipose tissue, which causes obesity and derived diseases. Synthetic sweeteners have the most cytotoxic alterations, whereas natural sweeteners, except steviosides, do not present adverse effects. Multiple investigations explain the impact of nonnutritive sweetener consumption on metabolism and related cytotoxic effects. Conclusion: The issue of sweeteners is controversial; therefore the information compiled in this review seeks to provide a panorama that helps understand the cellular and metabolic level responses of their consumption.

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“…A herbarium sheet was prepared and it was send to head of Botany Department of Government College , Rampurhat , Extraction may be defined as the treatment of the plant or animals tissues with solvent ,where by the medicinally active constituents are dissolve (menstrum) and most of the inert matter remains undissolved (marc) .The effective extraction of leaves depends largely on solubility and functional group consideration. [5] Soxhlet Extraction:…”

Section: Authenticationmentioning

confidence: 99%

Evaluation of Methanolic Extract of Clitoria ternatea Hepatoprotective & Nephroprotective Activity in Rats

Chandra¹

2019

J. Drug Delivery Ther.

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Objective: The aim of the study was to investigate the nephroprotective & hepatoprotective activity of methanolic extract of Clitoria ternatea in Cisplatin & CCl4 induced in rats Methods: Methanolic extract of aerial part of Clitoria ternatea plant was studied for its Nephroprotective & Hepatoprotective activity in animal experiment models. Nephrotoxicity was induced by Cystone 16 mg/kg b.w . Standard drug was taken Silymarin .Test drug were given methanolic extract Clitoria ternatea 500 mg/kg , 1000 mg/kg . Hepatoxicity was induced by CCl4 .Standard drug was taken cisplatin 100 mg/kg . Test drugs were given extract of Clitoria ternatea 500 mg/kg & 1000 mg/kg as per b.w Results : In Hepatoprotective activity positive control group was provided with CCl4 and increased SGPT , SGOT , ALP level compare to negative control group whereas Test(2) group was provided with methanolic extract of Clitoria ternatea 1000 mg/kg decreased SGPT , SGOT , ALP level compare to standard group. In nephroprotective activity positive control group was provided with CCl4 increased Urea and creatinine level where as Test(2) group are provided with methanolic extract of Clitoria ternatea 1000 mg/kg decreased urea and creatinine level Conclusion: On evaluating biochemical parameters it was found that methanolic extract of Clitoria ternatea 1000 mg/kg showed hepatoprotective and nephroprotective activity in rats. Keywords: SGPT, SGOT, ALP, Nephroprotective, Hepatoprotective

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Biological activity of Stevia rebaudiana Bertoni and their relationship to health

Cited by 99 publications

References 52 publications

Attenuation of metabolic dysfunctions in the skeletal muscles of type 1 diabetic rats by Stevia rebaudiana extracts, via AMPK upregulation and antioxidant activities [pdf]

Attenuation of metabolic dysfunctions in the skeletal muscles of type 1 diabetic rats by Stevia rebaudiana extracts, via AMPK upregulation and antioxidant activities [pdf]

Consumo de edulcorantes no nutritivos: efectos a nivel celular y metabólico

Evaluation of Methanolic Extract of Clitoria ternatea Hepatoprotective & Nephroprotective Activity in Rats

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