Biological activity of maleic anhydride copolymers. I. Biocompatibility and antitumoural effects of maleic anhydride - vinyl acetate, maleic anhydride - methyl methacrylate and maleic anhydride- styrene copolymers

Uglea, Constantin V.; Panaitescu, Luminita; Spridon, Daniela; Ursu, Daniel; Popa, Iuliana; Ottenbrite, Raphael M.

doi:10.1163/156856296x00291

Cited by 13 publications

(10 citation statements)

References 8 publications

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“…The evaluations of the copolymer molecular weight were carried out by GPC and viscosimetry; in the latter case, the following Mark-Houwink relationships were used [6]: (1) for MA-VA copolymer in acetone. for MA-S copolymer in tetrahydrofuran.…”

Section: Resultsmentioning

confidence: 99%

“…The synthesis procedures followed were similar to those reported [6,7]. The molar ratio in the feed monomer composition was 1 : 1; BP was introduced at 0.05-2% of the monomer concentration.…”

Section: Copolymer Synthesismentioning

confidence: 99%

“…The copolymerization reactions were carried out under a nitrogen atmosphere at 30°C for 8 h. The copolymers obtained were purified by reprecipitation and then dried under vacuum for 48 h at 45°C. The molecular weight was determined by GPC and viscometry using the Mark-Houwink equation [6].…”

Section: Copolymer Synthesismentioning

confidence: 99%

“…In addition, a molecular weight of over 30,000 and the presence of MM seem to be decisive parameters for the manifestation of a significant antitumor effect. Unfortunately, the treatment with MA copolymers also influenced the hematological parameters causing significant variations of certain organ weight and hepatic hypoglycemia [6].…”

Section: Biological Evaluationsmentioning

confidence: 99%

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Influence of Molecular Weight on the Biological Effects of Benzocaine Modified Maleic Anhydride Copolymer

Uglea¹,

Pârv²,

Dumitriu³

et al. 2006

Journal of Bioactive and Compatible Polymers

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A new series of polyanionic polymers with antitumor activity were synthesized by conjugating ethyl 4-aminobenzoate onto a series of maleic anhydride (MA) copolymers of vinyl acetate, methyl methacrylate, and styrene. The molecular weight of these copolymers ranged from 18 ϫ 10 3 to 2 ϫ 10 5 . The in vivo and in vitro biological tests showed that the maleic anhydride synthesized copolymers exhibit prolonged half-life in serum, accumulate in K 562 erythroleukemia solid tumors, and inhibit tumor growth. The antitumor activity appears to be increased by the enhanced permeability and retention (EPR) effect which is related to the macromolecular size of the antitumor agent.

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Section: Resultsmentioning

confidence: 99%

Section: Copolymer Synthesismentioning

confidence: 99%

Section: Copolymer Synthesismentioning

confidence: 99%

Section: Biological Evaluationsmentioning

confidence: 99%

See 2 more Smart Citations

Influence of Molecular Weight on the Biological Effects of Benzocaine Modified Maleic Anhydride Copolymer

Uglea¹,

Pârv²,

Dumitriu³

et al. 2006

Journal of Bioactive and Compatible Polymers

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“…Administration of MA copolymers caused significant variation in certain organ weights without significant modification of the body weight [24,25]. The data given in Table 1 indicate that these compounds induced significant weight increases in the liver, spleen, and particularly the kidney (490%).…”

Section: Effect Of Polymers On Internal Organ Weightsmentioning

confidence: 97%

Antitumoral Activity Induced by Alkylating Agents Conjugated to Poly(maleic anhydride-alt-vinyl acetate)

Popa

Şunel

Dulea

et al. 2007

Journal of Bioactive and Compatible Polymers

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New polyanionic polymer conjugates with antitumoral activity are synthesized by chemically binding mustard type alkylating derivatives of di-(-chloroethyl)-amine and tri-(-chloroethyl)-amine, respectively, onto poly(maleic anhydride-alt-vinyl acetate). The structures of the compounds are verified by FTIR, 1 H NMR, and elemental analysis. The antitumoral activity of these polymeric drugs is evaluated in vivo using carcinosarcoma Walker 256 solid tumors in Wister rats. The conjugates exhibit antitumor regression (ATR)

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Hydrophilic polystyrene/maleic anhydride ultrafine fibrous membranes

Cécile

Hsieh

2009

J of Applied Polymer Sci

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Polystyrene/maleic anhydride (PSMA) was synthesized to reach a viscosity-average molecular weight of 700 kDa and fabricated into ultrafine fibrous membranes consisting of fibers with an average diameter of 300 nm. These ultrafine PSMA fibers were rendered insoluble in organic solvents by reactions with hydrazine and ethylenediamine (ED). The highly efficient incorporation of diamines into the fibrous membranes was easily achieved by brief immersions in either dilute (0.5 wt %) hydrazine for 1 min or ED ether solution for 2 min. Heating at 150 C for 5 min produced crosslinked PSMA with very little or no solubility in acetone with the retention of the fibrous membrane structure. The ED-crosslinked membranes were particularly stable to both bases and acids as well as hydrophilic solvents, had a 46 water contact angle, and absorbed 22 times the amount of water as the as-spun fibrous membrane. This postfiber-formation crosslinking approach was robust, highly efficient, and fast and required very little crosslinking reagent.

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Biological activity of maleic anhydride copolymers. I. Biocompatibility and antitumoural effects of maleic anhydride - vinyl acetate, maleic anhydride - methyl methacrylate and maleic anhydride- styrene copolymers

Cited by 13 publications

References 8 publications

Influence of Molecular Weight on the Biological Effects of Benzocaine Modified Maleic Anhydride Copolymer

Influence of Molecular Weight on the Biological Effects of Benzocaine Modified Maleic Anhydride Copolymer

Antitumoral Activity Induced by Alkylating Agents Conjugated to Poly(maleic anhydride-alt-vinyl acetate)

Hydrophilic polystyrene/maleic anhydride ultrafine fibrous membranes

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