A series of maleic anhydride (MA)–vinyl acetate (VA), MA–methyl methacrylate (MM) and MA–styrene (S) copolymers were prepared and characterized. By employing various amounts of initiator, MA–VA, MA–MM and MA–S copolymers with molecular weights ranging between 18 000 and 219 000 were obtained. The ‘in vivo’ and ‘in vitro’ tests performed on K562 cellular cultures (human chronic myeloid leukaemia) and also on Westar rats (inoculated with the Walker 256 carcinosarcome) showed that, as a function of the molecular weight, the copolymers synthesized had a 50% in vitro cytotoxicity and a mean tumour regression of a maximum of 68%. © 1997 SCI.

This review gives a brief survey of synthetic inhibitors of influenza virus which have been synthesized to date. It starts with a short introduction which describes the structure and mechanism of action of influenza virus and continues with the main research directions that have been used in order to inhibit the virus. This is followed by discussion of various synthetic materials, including synthesis and antiviral properties, which that have been tested against influenza virus. The most potent inhibitory compounds proved to be polyvalent, because of their high binding affinity and steric stabilization. Finally we conclude with a brief discussion on structural characteristics, a summary, and outlook overview.

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New polymers with antitumor activity were synthesized by conjugating ethyl p-aminobenzoate (benzocaine) and N-hydroxy-2,3-dihydroxybenzamide (Didox) onto carboxymethylcellulose (CMC) and oxidized CMC. The biological tests ( in vitro and in vivo) for these CMC derivatives exhibited prolonged half-life in serum, accumulation in the solid tumors, and inhibition of the tumor growth. The latter effect was attributed to the permeability and retention (EPR) effect.