Biological activity of nanocrystalline cerium dioxide

Ivanov, V. K.; Федотов, Г. Н.; Никулина, М. В.; Polezhaeva, O. S.; Omel’yanyuk, G. G.; Романенко, С. Н.; Korol, S. G.; Tret’yakov, Yu. D.

doi:10.1134/s0012500808060049

Cited by 10 publications

(3 citation statements)

References 6 publications

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“…The vast majority of studies looking into antibacterial properties of nanoceria have been performed with E. coli as it is the most commonly studied microorganism3762. Relatively fewer studies were performed against more clinically relevant bacteria like P. aeruginosa 4244.…”

Section: Discussionmentioning

confidence: 99%

pH-Controlled Cerium Oxide Nanoparticle Inhibition of Both Gram-Positive and Gram-Negative Bacteria Growth

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Geilich

Yazıcı

et al. 2017

Sci Rep

127

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Here, the antibacterial activity of dextran-coated nanoceria was examined against Pseudomonas aeruginosa and Staphylococcus epidermidis by varying the dose, the time of treatment, and the pH of the solution. Findings suggested that dextran-coated nanoceria particles were much more effective at killing P. aeruginosa and S. epidermidis at basic pH values (pH = 9) compared to acidic pH values (pH = 6) due to a smaller size and positive surface charge at pH 9. At pH 9, different particle concentrations did cause a delay in the growth of P. aeruginosa, whereas impressively S. epidermidis did not grow at all when treated with a 500 μg/mL nanoceria concentration for 24 hours. For both bacteria, a 2 log reduction and elevated amounts of reactive oxygen species (ROS) generation per colony were observed after 6 hours of treatment with nanoceria at pH 9 compared to untreated controls. After 6 hours of incubation with nanoceria at pH 9, P. aeruginosa showed drastic morphological changes as a result of cellular stress. In summary, this study provides significant evidence for the use of nanoceria (+4) for a wide range of anti-infection applications without resorting to the use of antibiotics, for which bacteria are developing a resistance towards anyway.

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Section: Discussionmentioning

confidence: 99%

pH-Controlled Cerium Oxide Nanoparticle Inhibition of Both Gram-Positive and Gram-Negative Bacteria Growth

Alpaslan

Geilich

Yazıcı

et al. 2017

Sci Rep

127

View full text Add to dashboard Cite

show abstract

“…In particular, CeO 2Àx particles can increase cell longevity and survival potential of various microand macroorganisms. 4,5 It was also shown that CeO 2Àx is promising in view of treatment of various human diseases including cancer. 3,5 In view of the fact that nanoceria biological activity is size-dependent, 4 extensive study of physical and chemical properties of CeO 2Àx is required paying special attention to its oxygen non-stoichiometry.…”

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confidence: 99%

“…1,2,6 Results obtained in these works differ notably, and relevant experimental data are still scarce. It must be particularly emphasized that in most cases ceria size-dependent properties have been studied using just a few samples (4)(5). Another one principal question that has not been reliably answered yet is whether unit cell parameter and concentration of oxygen vacancies in ceria depend on method of synthesis or not.…”

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confidence: 99%