Biological agents in the treatment of uveitis

Paroli, Maria Pia; Abbouda, Alessandro; Abicca, Irene; Sapìa, Alfredo; Paroli, Marino

doi:10.4236/abb.2013.48a2009

Cited by 7 publications

(5 citation statements)

References 68 publications

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“…Golimumab, Intliximab, Adalimumab, Ustekinumab, Secukinumab were studied in noninfection uveitis. Etanercept, although paradoxically responsible in very rare cases of the onset of uveitis in patients with inflammatory rheumatic conditions, is still an effective drug for the treatment of inflammatory ocular diseases [93][94][95][96][97][98][99][100][101][102][103][104][105][106][107].…”

Section: Review and Discussionmentioning

confidence: 99%

Features of Clinical Manifestations, Free Radical, Coagulation and Aggregation Properties of Blood in Patients With Craniocerebral Trauma

Пінчук

Sylenko

et al. 2019

Wiad Lek

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Introduction: In recent years in Ukraine, as in the entire world, there has been an increase in cases of domestic injuries with a raise in the number of patients with craniocerebral trauma and its consequences. The aim of our research was to study clinical symptoms, the state of free radical oxidation, aggregate and hemocoagulative properties of blood in patients with mild craniocerebral trauma. Materials and methods: We conducted comprehensive clinical and laboratory examination of 34 patients with mild craniocerebral trauma and 20 apparently healthy patients (the control group). The diagnosis was made under ICD-10. The verification of the diagnosis was based on data from clinical examination, neurological status of neuroimaging (computer tomography and magnetic resonance imaging). The study group included 24 men and 10 women aged from 19 to 40. In addition, 20 apparently healthy individuals of the same age were examined, who comprised the control group (14 men and 6 women). In the blood parameters of all patients, we examined free radical oxidation, hemostasis and aggregation properties of platelets. Results: The conducted study revealed clinical disturbances, changes in the parameters of free radical lipid oxidation, coagulation and microcirculatory hemostasis. Conclusions: All patients with mild craniocerebral trauma, develop disturbances in the form of symptoms of microorganic lesion of the central nervous system: convergence weakness in 100% of patients, Mann’s symptom (76.4%), disruption of the function of the cranial nerves (58.8%), signs of pyramidal insufficiency (68.4%), vestibular disorders (94.1%), autonomic vascular dysfunction (100%). Mild craniocerebral trauma is accompanied by the activation of free radical lipid oxidation processes, decreased activity of antioxidant enzymes, hypercoagulation, and increased aggregation properties of platelets.

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Section: Review and Discussionmentioning

confidence: 99%

Features of Clinical Manifestations, Free Radical, Coagulation and Aggregation Properties of Blood in Patients With Craniocerebral Trauma

Пінчук

Sylenko

et al. 2019

Wiad Lek

View full text Add to dashboard Cite

show abstract

Section: Review and Discussionmentioning

confidence: 99%

Peculiarities of Diagnostics of Depressions and Clinical Manifestations in Patients With Obesity and Concomitant Type 2 Diabetes Mellitus

2019

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Introduction: According to the World Health Organization, depression is a common mental disorder characterized by despair, loss of interest or joy, feelings of guilt and low self-esteem, sleep disturbance or appetite, lethargy, and poor concentration. There is a series of studies that show the presence of depressive disorders in patients with obesity concomitant type 2 diabetes mellitus, but in our study, we wanted to demonstrate the degree of severity of these changes. The aim: Diagnose depression in patients with obesity and concomitant type 2 diabetes mellitus. Materials and methods: Examine patients with obesity and concomitant type 2 diabetes mellitus and select them for research. For the diagnosis of depression were used: Patient Health Questionnaire – 2 and 9, Hospital Anxiety and Depression Scale and Hamilton Depression Scale. Along with hypoglycemic therapy, all patients with diagnosed depression were given individual psychotherapy: cognitive behavioral therapy - 12 sessions per week, interpersonal therapy - 12 sessions per week and bibliotherapy. Results: Using the questionnaires scales, we found depressive disorders in patients with obesity and concomitant type 2 diabetes mellitus. Along with the diagnosis of depression, we managed to correct it using individual psychotherapy. Conclusions: Patients with obesity and concomitant type 2 diabetes mellitus are in a cohort with an increased risk of depression and should be diagnosed early. Given these patients polypharmacotherapy, treatment for depression should begin with non-drug therapy.

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Section: Review and Discussionmentioning

confidence: 99%

Interaction Between Clinical and Psychological Changes Among Patients With Chronic Obstructive Pulmonary Disease and Pulmonary Tuberculosis Co-Morbidity

Zhovanyk

Tovt-Korshynska

2019

Wiad Lek

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Introduction: The association of chronic obstructive pulmonary disease and pulmonary tuberculosis is an important medical and social problem with a significant burden in terms of morbidity and mortality. The course and prognosis of chronic diseases such as chronic obstructive pulmonary disease and pulmonary tuberculosis is greatly influenced not only by the clinical features but also by the psychological characteristics of the patient. The aim: To study the interaction between clinical changes and psychological characteristics considering gender differences among patients with chronic obstructive pulmonary disease in association with pulmonary tuberculosis. Materials and methods: We studied 41patients with chronic obstructive pulmonary disease (grade 2, 3, groups А, B, С, D) and infiltrative pulmonary tuberculosis co-morbidity (11 women and 30 men). All patients underwent general clinical examination, Acid-Fast Bacillus Testing, spirometry, Spielberg anxiety scale, Beck depression scale. Results: Patients with chronic obstructive pulmonary disease and pulmonary tuberculosis co-morbidity with more severe symptoms (according to Assesment Test scores) were older and, regardless of it, showed elevated depression and personal anxiety scores while situational anxiety scores were significantly lower compared to those with less severe symptoms. The correlation between symptoms severity and airflow limitation or smoking history was very mild. The elevated depression and personal anxiety could cause more severe symptoms. The revealed discrepancy between the symptoms severity and low levels of situational anxiety may be due to adaptation with displacement mechanisms to illness related chronic life stressors. We also observed elevated personal anxiety and depression scores together with less severe symptoms among female versus male chronic obstructive pulmonary disease/pulmonary tuberculosis patients, possibly reflecting physically ill women’s higher risk for depressive and anxiety related symptomatology relative to ill men. Conclusions: We revealed that among patients with chronic obstructive pulmonary disease and pulmonary tuberculosis co-morbidity symptoms severity was largely influenced by the patients’ age, gender and psychological factors (depression and personal anxiety), but, unexpectedly, much less – by airflow limitation and smoking history. We also found higher emotional distress, namely elevated personal anxiety and depression scores, in combination with less severe symptoms among female versus male patients with chronic obstructive pulmonary disease and pulmonary tuberculosis co-morbidity.

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Biological agents in the treatment of uveitis

Cited by 7 publications

References 68 publications

Features of Clinical Manifestations, Free Radical, Coagulation and Aggregation Properties of Blood in Patients With Craniocerebral Trauma

Features of Clinical Manifestations, Free Radical, Coagulation and Aggregation Properties of Blood in Patients With Craniocerebral Trauma

Peculiarities of Diagnostics of Depressions and Clinical Manifestations in Patients With Obesity and Concomitant Type 2 Diabetes Mellitus

Interaction Between Clinical and Psychological Changes Among Patients With Chronic Obstructive Pulmonary Disease and Pulmonary Tuberculosis Co-Morbidity

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