Biological and Biochemical Actions of Trichothecene Mycotoxins

Bamburg, James R.

doi:10.1007/978-3-642-69228-4_3

Cited by 60 publications

(32 citation statements)

References 227 publications

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“…They have been implicated as chemical warfare agents (28) tso-called "Yellow Rain 11 , a topic of some controversy (29)], and employed in clinical trials in the treatment of cancer (30), but they are probably best known for their role as mycotoxins, fungal metabolites which pose a serious hazard to man and farm animals by their contamination of food and feeds (27,(31)(32)(33)(34)(35)(36).…”

Section: Pene Lactones 1-4·mentioning

confidence: 99%

Allelopathic Agents from Parthenium hysterophorus and Baccharis megapotamica

Jarvis

Pena

Rao

et al. 1985

ACS Symposium Series

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Parthenium hysterophorus is a weed with a history of being an agricultural pest.A water extraction of P. hysterophorous has yielded parthenin, coronopilin, and two new sesquiterpene lactones closely related in structure to the former com pounds. These compounds are believed to be responsible, at least in part, for the allelopathic properties of this plant. An alcohol extract of the Brazilian shrub, Baccharis megapotamica has yielded a large number of closely related, highly toxic sesquiterpenes belonging to a class of mycotoxins known as the macrocyclic trichothecenes. Evidence has been gathered to show that these compounds are acquired by B. megapotamica from a fungal source and oxygenated by the plants to yield the baccharinoids which are potent in vivo active antileukemic agents. A large scale extraction (1800 Kg) has yielded over twenty different macrocyclic trichothecenes.In this chapter we are focusing on two different plants which appear to express allelopathy in quite different fashions.The first, Parthenium hysterophorus Linn, is recognized in many parts of the world as causing serious agricultural problems due principally to its invasion of crop lands and the subsequent lowering of crop yields (1,)·

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Section: Pene Lactones 1-4·mentioning

confidence: 99%

Allelopathic Agents from Parthenium hysterophorus and Baccharis megapotamica

Jarvis

Pena

Rao

et al. 1985

ACS Symposium Series

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“…These toxins have often been implicated as causative agents in outbreaks of mycotoxicosis in humans and farm animals (Bamburg 1983;Hsu et al 1972;Joffe 1974).…”

Section: Introductionmentioning

confidence: 98%

Protein synthesis inhibition and cardiac lesions associated with deoxynivalenol ingestion in mice

Robbana-Barnat

Loridon-Rosa

Cohen³

et al. 1987

Food Additives and Contaminants

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Deoxynivalenol (DON), an occasional contaminant of foodstuffs, has been implicated in outbreaks of mycotoxicosis. Balb-c mice that had ingested 0.35 mg/kg of DON showed a drastic decrease in food intake and concomitant loss of weight. Severe depletion of the lymphoid organs and liver were also observed. Cardiac lesions, appeared as calcified pericarditis foci in young animals fed a diet contaminated by 10 to 20 ppm of DON for a period of a few weeks. DON inhibited protein synthesis. This inhibition occurred at lower doses for the heart than for the other organs. This preferential effect on cardiac tissue correlated with the cardiotoxicity observed.

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“…Altering the biological activity of trichothecenes has helped in inducing anti-bacterial, anti-viral, insecticidal, phytotoxic, cytoxic, anti-biotic and anti-tumour properties in the resultant molecules [8]. Konishi et al reported the trichothecinols A-C, all showing remarkable potential at inhibiting EBV-EA activation induced by TPA (12-O-tetradecanoylphorbol-13-acetate) in Raji cells [9].…”

Section: Introductionmentioning

confidence: 99%

Isolation, purification and characterization of Trichothecinol-A produced by endophytic fungus Trichotheciumsp. and its antifungal, anticancer and antimetastatic activities

Taware

Abnave

Patil

et al. 2014

Sustain Chem Process

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Background: A total of 30 endophytic fungi (AAP-PS 1-30) were isolated from the medicinal herb Phyllanthus amarus and screened for the production of Trichothecinol-A. Out of all the endophytic strains screened for Trichothecinol-A production, the culture filtrate of AAP-PS-1 extracted with ethyl acetate yielded Trichothecinol-A extracellularly in appreciable amounts. Trichothecinol-A was purified, quantified and completely characterized by different standard chromatographic and spectroscopic techniques including reverse phase HPLC, 1D and 2D NMR spectroscopy, etc. The compound was tested for antifungal activity against filamentous fungi and yeast, apoptotic activity against B16F10 cells, anticancer activity against MDA-MB-231, HeLa and B16F10 cells as well as antimetastatic activity against MDA-MB-231 cell line.

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Biological and Biochemical Actions of Trichothecene Mycotoxins

Cited by 60 publications

References 227 publications

Allelopathic Agents from Parthenium hysterophorus and Baccharis megapotamica

Allelopathic Agents from Parthenium hysterophorus and Baccharis megapotamica

Protein synthesis inhibition and cardiac lesions associated with deoxynivalenol ingestion in mice

Isolation, purification and characterization of Trichothecinol-A produced by endophytic fungus Trichotheciumsp. and its antifungal, anticancer and antimetastatic activities

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