Biological and environmental media control oxide nanoparticle surface composition: the roles of biological components (proteins and amino acids), inorganic oxyanions and humic acid

Mudunkotuwa, Imali A.; Grassian, Vicki H.

doi:10.1039/c4en00215f

Cited by 66 publications

(78 citation statements)

References 59 publications

(124 reference statements)

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“…For information on the differences of toxic effects dependent on media composition, the following reviews on the subject are recommended. [49][50][51][52] Damage to specific cells and cellular structures is also actively studied to determine specific biological responses and possible toxicological mechanisms between AgNPs and the structures. Incurred DNA damage by Ag + release is noted to be size independent.…”

Section: Toxicitymentioning

confidence: 99%

Antibacterial properties and toxicity from metallic nanomaterials

Vimbela¹,

Ngo²,

Fraze³

et al. 2017

IJN

532

334

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The era of antibiotic resistance is a cause of increasing concern as bacteria continue to develop adaptive countermeasures against current antibiotics at an alarming rate. In recent years, studies have reported nanoparticles as a promising alternative to antibacterial reagents because of their exhibited antibacterial activity in several biomedical applications, including drug and gene delivery, tissue engineering, and imaging. Moreover, nanomaterial research has led to reports of a possible relationship between the morphological characteristics of a nanomaterial and the magnitude of its delivered toxicity. However, conventional synthesis of nanoparticles requires harsh chemicals and costly energy consumption. Additionally, the exact relationship between toxicity and morphology of nanomaterials has not been well established. Here, we review the recent advancements in synthesis techniques for silver, gold, copper, titanium, zinc oxide, and magnesium oxide nanomaterials and composites, with a focus on the toxicity exhibited by nanomaterials of multidimensions. This article highlights the benefits of selecting each material or metal-based composite for certain applications while also addressing possible setbacks and the toxic effects of the nanomaterials on the environment.

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Section: Toxicitymentioning

confidence: 99%

Antibacterial properties and toxicity from metallic nanomaterials

Vimbela¹,

Ngo²,

Fraze³

et al. 2017

IJN

532

334

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“…Because of the high surface free energy, TiO 2 NPs in biological medium absorb biological components, primarily proteins and amino acids 53 . In particular, proteins bind to the NPs surface and construct the protein corona or biological coating 54 .…”

Section: Discussionmentioning

confidence: 99%

Titanium dioxide nanoparticle ingestion alters nutrient absorption in an in vitro model of the small intestine

et al. 2017

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Ingestion of titanium dioxide (TiO2) nanoparticles from products such as agricultural chemicals, processed food, and nutritional supplements is nearly unavoidable. The gastrointestinal tract serves as a critical interface between the body and the external environment, and is the site of essential nutrient absorption. The goal of this study was to examine the effects of ingesting the 30 nm TiO2 nanoparticles with an in vitro cell culture model of the small intestinal epithelium, and to determine how acute or chronic exposure to nano-TiO2 influences intestinal barrier function, reactive oxygen species generation, proinflammatory signaling, nutrient absorption (iron, zinc, fatty acids), and brush border membrane enzyme function (intestinal alkaline phosphatase). A Caco-2/HT29-MTX cell culture model was exposed to physiologically relevant doses of TiO2 nanoparticles for acute (four hours) or chronic (five days) time periods. Exposure to TiO2 nanoparticles significantly decreased intestinal barrier function following chronic exposure. Reactive oxygen species (ROS) generation, proinflammatory signaling, and intestinal alkaline phosphatase activity all showed increases in response to nano-TiO2. Iron, zinc, and fatty acid transport were significantly decreased following exposure to TiO2 nanoparticles. This is because nanoparticle exposure induced a decrease in absorptive microvilli in the intestinal epithelial cells. Nutrient transporter protein gene expression was also altered, suggesting that cells are working to regulate the transport mechanisms disturbed by nanoparticle ingestion. Overall, these results show that intestinal epithelial cells are affected at a functional level by physiologically relevant exposure to nanoparticles commonly ingested from food.

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“…Specifically, the dispersion stability, particle size, and dissolution rate can vary significantly in biologically relevant media due to changes in pH and the presence of salts and proteins, which have the potential to fundamentally alter how 2D materials interact with or are taken up by cells. 180 …”

Section: Future Outlookmentioning

confidence: 99%

Assessing and Mitigating the Hazard Potential of Two-Dimensional Materials

Guiney¹,

Wang

Xia

et al. 2018

ACS Nano

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The family of two-dimensional (2D) materials is comprised of a continually expanding palette of unique compositions and properties with potential applications in electronics, optoelectronics, energy capture and storage, catalysis, and nanomedicine. To accelerate the implementation of 2D materials in widely disseminated technologies, human health and environmental implications need to be addressed. While extensive research has focused on assessing the toxicity and environmental fate of graphene and related carbon nanomaterials, the potential hazards of other 2D materials have only recently begun to be explored. Herein, the toxicity and environmental fate of post-carbon 2D materials, such as transition metal dichalcogenides, hexagonal boron nitride, and black phosphorus, are reviewed as a function of their preparation methods and surface functionalization. Specifically, we delineate how the hazard potential of 2D materials is directly related to structural parameters and physicochemical properties, and how experimental design is critical to the accurate elucidation of the underlying toxicological mechanisms. Finally, a multidisciplinary approach for streamlining the hazard assessment of emerging 2D materials is outlined, thereby providing a pathway for accelerating their safe use in a range of technologically relevant contexts.

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Biological and environmental media control oxide nanoparticle surface composition: the roles of biological components (proteins and amino acids), inorganic oxyanions and humic acid

Cited by 66 publications

References 59 publications

Antibacterial properties and toxicity from metallic nanomaterials

Antibacterial properties and toxicity from metallic nanomaterials

Titanium dioxide nanoparticle ingestion alters nutrient absorption in an in vitro model of the small intestine

Assessing and Mitigating the Hazard Potential of Two-Dimensional Materials

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