Biological and Medical Significance of Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin, Sergey V.

doi:10.1002/9781118523025.ch2

Cited by 6 publications

(3 citation statements)

References 719 publications

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“…Nanocrystalline calcium phosphates degrade faster than micron (or conventional) grain size calcium phosphates. Nanocrystalline HA exhibits improved sinterability and enhanced densification due to greater surface area, which may improve fracture toughness as well as other mechanical properties [15]. It should be mentioned that calcium phosphate compounds with Ca/P ratio of < 1:1 are not suitable for Reprinted with permission from Ref.…”

Section: Figure 2 (A)mentioning

confidence: 99%

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Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

Yousefi

Oudadesse

Akbarzadeh

et al. 2014

Nanotechnology Reviews

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Critical-sized bone defects have, in many cases, posed challenges to the current gold standard treatments. Bioactive glasses are reported to be able to stimulate more bone regeneration than other bioactive ceramics; however, the difficulty in producing porous scaffolds made of bioactive glasses has limited their extensive use in bone regeneration. On the other hand, calcium phosphate ceramics such as synthetic hydroxyapatite and tricalcium phosphate are widely used in the clinic, but they stimulate less bone regeneration. This paper gives an overview of the recent developments in the field of bioactive nanoparticles, with a focus on nanohydroxyapatite and bioactive glasses for bone repair and regeneration. First, a brief overview of the chemical structure and common methods used to produce synthetic nanohydroxyapatite and bioactive glasses has been presented. The main body of the paper covers the physical and biological properties of these biomaterials, as well as their composites with biodegradable polymers used in bone regeneration. A summary of existing challenges and some recommendations for future directions have been brought in the concluding section of this paper.

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Section: Figure 2 (A)mentioning

confidence: 99%

“…The study included needle-shaped (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) , the stronger the toxicity (Figure 8) [80]. Most of the cytotoxicity was attributed to apoptosis rather than necrosis.…”

Section: Biological Propertiesmentioning

confidence: 99%

Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

Yousefi

Oudadesse

Akbarzadeh

et al. 2014

Nanotechnology Reviews

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“…It is desirable for bone grafting material to have the ability to dissolve over a period allowing the formation of new bone instead. As the degradation rate of HA highly depends on its particle size, Nano-particles HA (N-HA) dissolve faster than conventional HA because of their high surface-to-volume ratio 9 . From the biological side, N-HA demonstrated superior biocompatibility and osteointegration as bone graft substitutes.…”

Section: Introductionmentioning

confidence: 99%

Eggshells derived Nano-hydroxyapatite doped with Si and Zn as novel bone regenerative material in critical-sized bone defects – in vitro and in vivo study

Alashi,

kouri,

Alghoraibi

et al. 2023

Preprint

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Hydroxyapatite Nano-particles are the most abundant inorganic compound found in bone tissue. Nano-hydroxyapatite (N-HA) was synthesized by different methods to be used as bone substitution material due to its favorable biocompatibility and biological activity. To mimic the natural structure of bone inorganic phase, N-HA has been doped with several ions to enhance its degradation and cell interaction. In this work, using the wet chemical precipitation method, N-HA was synthesized from eggshells as a bio-waste source and doped with silicon (Si+ 4) and zinc (Zn+ 2). Spherical Nano-sized particles of hydroxyapatite (HA) were obtained with a high surface area and an interconnected porous structure. The average particle size was 239 nm, and the average porosity of 20%. The substitution of Si+ 4 and Zn+ 2 into N-HA crystal lattice affected physical features by decreasing the particle size and crystallinity. The crystal size of N-HA decreased from 61 nm to 46 nm after the dual doping. Doping ions also improved the biological behavior of N-HA by increasing the cell viability of N-HA in vitro. Synthesis of N-HA from eggshells seemed to affect the phase purity of the material, a phase of whitlockite (WH) appeared in N-HA powder even after was sintered at a high temperature of 1200○c. The in vivo results demonstrated the ability of Si –Zn doped HA to well integrate into bone tissue and induce bone regeneration in critical-sized bone defects. Histological analysis showed that the mean value of newly-formed bone area (total bone area/total area) measured via histomorphometric reached 69%±0.015% after 12 weeks in grafted defects. Furthermore, significant differences in bone formation were found between grafted and control samples. We present our study to be a starting point for more investigation into the ability to synthesize a biomimicry bone substitution martial that meets the renewable requirements in the bone regeneration field.

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Hydrothermal synthesis of nanocrystalline hydroxyapatite–graphene nanosheet on Ti-6Al-7Nb: mechanical and in vitro corrosion performance

Yiğit

Dikici

Özdemir

2021

J Mater Sci: Mater Med

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The hybrid coatings containing the graphene nano-sheet (GNS) and nano-hydroxyapatite (nHA) phases have been successfully synthesized on Ti6Al7Nb alloys by a one-step hydrothermal method. The hydrothermal reaction was carried out for 24 h at 200 °C. The GNS ratio has been altered as 1, 3, 5 and 7 wt.% in the coatings and, the results have compared with non- GNS containing coatings. The effect of the GNS ratio on the microstructure, hardness, and in vitro corrosion responses has been investigated in detail. The characterizations of the coatings were carried out by SEM, EDS, AFM, XRD and, FTIR. The corrosion behavior of the hybrid coatings was compared in Kokubo’s solution at 37 °C by using potentiodynamic polarization tests. The results showed that the hydroxyapatite phases were deposed on the graphene layers with nano-size nucleation with its Ca/P stoichiometric ratio. The best hydrophilicity (~52°) property has been obtained in nHA/3GNS coatings. In addition, the corrosion rates of coatings increased in the following order: nHA/3GNS < nHA/1GNS < nHA/7GNS < nHA/5GNS < only nHA.

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Biological and Medical Significance of Nanodimensional and Nanocrystalline Calcium Orthophosphates

Cited by 6 publications

References 719 publications

Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

Eggshells derived Nano-hydroxyapatite doped with Si and Zn as novel bone regenerative material in critical-sized bone defects – in vitro and in vivo study

Hydrothermal synthesis of nanocrystalline hydroxyapatite–graphene nanosheet on Ti-6Al-7Nb: mechanical and in vitro corrosion performance

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