Biological and other health related correlates of long-term life dissatisfaction burden

Abstract

BackgroundMental health is interconnected with somatic health and can manifest itself in biological processes. Life dissatisfaction is an indicator of subjective well-being, but information on its biological correlates is scarce. The aim of this study was to investigate the biological correlates along with other health-related factors of long-term life dissatisfaction in a population-based sample.MethodsAs part of the Kuopio Depression Study, health questionnaires were sent to a randomly selected population-based sample in 1998, 1999, and 2001. In 2005, among a clinically studied sub-sample (n = 305), the 7-year long-term life dissatisfaction burden was assessed by summing life satisfaction scores from previous health questionnaires. Several sociodemographic, health, health behavior, and biological factors were investigated in respect to their associations to categorized (low and high) and continuous (linear regression) life satisfaction burden score (higher values indicating dissatisfaction).ResultsIn the final linear regression model long-term life dissatisfaction burden was significantly associated with poor social support (B = 0.138; p < 0.001), marital status (i.e. living alone) (B = 0.049; p = 0.019), current smoking (B = 0.087; p < 0.001), poor sleep (B = 0.052; p = 0.001), use of statins (B = −0.052; p = 0.002) and lower serum adiponectin level (B = −0.001; p = 0.039) whereas association of metabolic syndrome was marginally nonsignificant (B = 0.029; p = 0.055).ConclusionLong-term life dissatisfaction is associated with adverse health, health behavioral, and social factors, as well as with a decreased anti-inflammatory buffer capacity, all indicating close relationships between subjective well-being and somatic morbidity.

Sleep Duration and Sleep Quality as Predictors of Health in Elderly Individuals

“…To the best of the authors' knowledge, this is the first exploration of the associations of both sleep duration and sleep quality with self-rated health in a sample of elderly individuals. Since this is the first of such studies, our results were explained in the highlights of similar studies [27,28]. Specifically, Paunio et al [27] and Rissanen et al [28] showed that 'poor' sleep quality was associated with 'poor' life satisfaction in the general population.…”

“…Since this is the first of such studies, our results were explained in the highlights of similar studies [27,28]. Specifically, Paunio et al [27] and Rissanen et al [28] showed that 'poor' sleep quality was associated with 'poor' life satisfaction in the general population. Our results could be explained by the fact that life satisfaction was strongly associated with self-rated health in previous studies [29].…”

Peptides from adipose tissue in mental disorders

“…Adiponectin activity is strongly associated with metabolic disorders and energy expenditure interactions, but it has also been associated with various mental disorders such as mood disorders, anxiety disorders, eating and sleep Decreased serum adiponectin levels have been also reported in major depressive disorders, panic disorders and schizophrenia [41][42][43] . Serum levels of adiponectin were significantly lower in elderly patients with major depressive disorders than in non-depressed controls [44,45] . Adiponectin also plays an important role in depression-related behaviors.…”

Life satisfaction and inflammation in couples: an actor–partner analysis

“…In one of the first studies, Hamer and Chida (2011) found that life satisfaction predicted lower CRP levels in the Scottish Health Survey (also see Nowakowski, 2014). However, the population-based Kuopio Depression Study did not find life satisfaction to be significantly related to either IL-6 or CRP, although it was related to higher levels of the anti-inflammatory adipokine adiponectin (Rissanen et al, 2013). Although more work is needed using a broader panel of inflammatory markers, results of the current study are important because CRP and IL-6 are robust predictors of future cardiovascular risk (Bisoendial et al, 2010; Libby et al, 2002).…”

“…Two important markers of inflammation include interleukin-6 (IL-6) and C-reactive protein (CRP) which predict future risk for cardiovascular disease and related mortality (Bisoendial, Boekholdt, Vergeer, Stroes, & Kastelein, 2010; Hunter & Jones, 2015; O Hartaigh et al, 2013). To date, only three studies appear to have tested the link between life satisfaction and inflammation: Two have found life satisfaction to predict lower CRP and IL-6 levels (Hamer & Chida, 2011; Nowakowski, 2014) while the other study did not (Rissanen et al, 2013). Thus, more research is needed modeling these inflammatory biological pathways.…”