Biological and pathophysiological role of adiponectin

Petrenko, Yu. V.; Валентинович, Петренко Юрий; Gerasimova, Ksenia S.; Сергеевна, Герасимова Ксения; Новикова, В. П.; Павловна, Новикова Валерия

doi:10.17816/ped10283-87

Cited by 6 publications

(3 citation statements)

References 24 publications

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“…Следующим этапом исследования было включение изучаемых адипокинов в логистический регрессионный анализ. Учитывая установленные связи между адипонектином и инсулинорезистентностью, ожирением и дислипидемией [14], логично предположить, что повышение уровня адипонектина должно играть за-ХС неЛВП в разных странах [13], говорить о широком применении данного показателя для стратификации риска развития ССЗ в настоящее время видится не совсем корректным. Ранее было показано, что уровень резистина может выступать в качестве маркера стратификации риска неблагоприятного течения ИБС у пациентов, перенесших коронарное стентирование [19].…”

Section: Discussionunclassified

Associations of circulating adipokines and coronary artery disease in young adults

Khudiakova,

Polonskaya,

Shcherbakova

et al. 2024

Cardiovasc Ther Prev

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Aim. To evaluate the associations of abdominal obesity (AO), adipokines and premature coronary artery disease (CAD) in young people for a deeper understanding of the pathogenesis of atherosclerotic diseases.Material and methods. A total of 1457 people were examined, including 653 (44,8%) men. Mean age was 36,7±6,0 years. Premature CAD was detected in 46 people, while 4 following subgroups were formed (138 people in total): with CAD and AO; with CAD, without AO; control groups by age and sex: without CAD, with AO; without CAD, without AO.Results. Premature CAD in young people is associated with an increase in non-high-density lipoprotein cholesterol (non-HDL-C). Univariate analysis found that the probability of CAD increased by 1% with an increase in adiponectin level, and by 0,2% with an increase of 1 ng/ml in resistin level. Multivariate regression analysis, including sex, age, waist circumference, non-HD-C, adiponectin, and resistin, significant associations were obtained for non-HDL-C and adiponectin. With AO, the CAD probability increased by 0,6% with an increase in plasminogen activator inhibitor-1 level (PAI-1). However, when non-HDL-C was included in the model, significance for this biomarker was not achieved.Conclusion. In young people, CAD is associated with increased levels of non-HDL cholesterol, adiponectin, resistin and PAI-1. Independent associations with premature CAD were obtained only for adiponectin, which makes this marker promising for study in young people.

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Section: Discussionunclassified

Associations of circulating adipokines and coronary artery disease in young adults

Khudiakova,

Polonskaya,

Shcherbakova

et al. 2024

Cardiovasc Ther Prev

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“…Кишечная микробиота способна изменять кишечный барьер, разрушать белки плотных соединений и снижать секрецию антимикробных пептидов [3]. Весь этот каскад реакций приводит к иммунным нарушениям, возможной транслокации отдельных представителей микрофлоры кишки, низкоинтенсивному воспалению, и изменению выработки микокинов-адипокинов [48,49].…”

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Axis “microbiota - muscle”

Zavyalova

Novikova

Ignatova

2023

jour

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The luminal intestinal microflora affects the state of the muscular system of experimental animals and humans. The role of nutrition in the development of skeletal muscles is considered. The role of metabolically active substances secreted by the microbiota in the development of cachexia, sarcopenia, and kwashiorkor is considered. The effect of exercise on the gut microbiome was assessed. Possible variants of the influence of probiotics on the state of skeletal muscles and its functional activity in the experiment in animals and humans are presented.

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“…[7]. Получены данные, согласно которым уменьшение массы тела у пациентов, страдающих ожирением, при переходе на низкокалорийную диету способствует повышению концентрации адипонектина в плазме крови [3,8].…”

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Association of rs266729 and rs16861194 polymorphisms of the ADIPOQ gene with the risk of obesity in residents of the Moscow region

Погожева

Sorokina

2021

Alʹm. klin. med.

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Rationale: The contribution of the adiponectin gene polymorphisms (ADIPOQ, located at 3q27) in the residents of Nigeria and China to the risk of overweight and its association with the risk of arterial hypertension in the European population have been demonstrated.Aim: To identify associations between rs266729 and rs16861194 polymorphisms of the ADIPOQ gene with overweight and obesity in the Moscow region residents.Materials and methods: Identification of rs266729 and rs16861194 polymorphisms of the ADIPOQ gene was carried out in 222 people (140 women and 82 men, aged 25 to 65 years) living in the Moscow region. Genotyping was performed using allele-specific amplification with real-time detection of the results on the CFX96 Real-Time System amplifier (Bio-Rad, USA) and using TaqMan probes complementary to polymorphic DNA regions. To assess an association between these genetic polymorphisms and overweight/obesity, we performed a case control study, with the cases being subjects with body mass index (BMI) of ≥ 30 kg/m2, and the controls those with BMI of < 30 kg/m2.Results: The mean frequency of the minor allele G rs266729 polymorphism of the ADIPOQ gene in the subjects from the Moscow region was 26.8% and similar in men and women. Comparison of the CC and GG genotypes carriers of the rs266729 polymorphism of the ADIPOQ gene in men showed a statistically significant association of the GG genotype to the BMI value (p = 0.04). There were no statistically significant differences between anthropometric indicators (BMI, body fat mass) in the carriers of different rs16861194 polymorphism genotypes of the ADIPOQ. No association between the studied polymorphisms and blood glucose levels and lipid spectrum could be found.Conclusion: The frequency of the minor allele G of the rs266729 polymorphism of the ADIPOQ gene in the subjects from the Moscow region was similar to their rates in the Russian Federation and European countries. In Moscow residents, the rs266729 polymorphism of the ADIPOQ gene (G allele) contributes to the risk of obesity in homozygous carriers (genotype GG). No association of the rs16861194 polymorphism of the ADIPOQ gene with the BMI was found; therefore, this polymorphism cannot be considered as a genetic marker of the obesity risk.

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Biological and pathophysiological role of adiponectin

Cited by 6 publications

References 24 publications

Associations of circulating adipokines and coronary artery disease in young adults

Associations of circulating adipokines and coronary artery disease in young adults

Axis “microbiota - muscle”

Association of rs266729 and rs16861194 polymorphisms of the ADIPOQ gene with the risk of obesity in residents of the Moscow region

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