Biological applications of LbL multilayer capsules: From drug delivery to sensing

Mercato, Loretta L. del; Ferraro, Marzia Maria; Baldassarre, Francesca; Mancarella, Serena; Greco, Valentina; Rinaldi, R.; Leporatti, Stefano

doi:10.1016/j.cis.2014.02.014

Cited by 132 publications

(100 citation statements)

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“…Whilst the LBL assembly technique allows the design and modification of hollow microcapsules in a controllable way, the impregnation of the capsule shell with gold nanoparticles (AuNPs) is undoubtedly one of the most attractive ways to tailor their functionality [4][5][6][7]. For example, laser-induced remote drug release is based on localized heating due to surface plasmon resonance absorption by the nanoparticles [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

The effect of gold nanoparticles on the impedance of microcapsules visualized by scanning photo-induced impedance microscopy

Wang

Campos

et al. 2016

Electrochimica Acta

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Abstract:Polyelectrolyte microcapsules have attracted great interest in drug delivery applications, and microcapsules modified with gold nanoparticles have been used in this way with triggered release when a laser can be used to remotely open shells through light-induced local heating. The electrical impedance of unmodified microcapsules has been studied due to its implications for their permeability, however, the impedance of functionalised microcapsules has not yet been investigated. Herein, the impedance of microcapsules modified with gold nanoparticles was studied for the first time. It was shown that the modification of microcapsules with gold nanoparticles leads to a much greater impedance than would be expected from the increase in the thickness caused by the presence of a layer of gold nanoparticles alone. The impedance of gold nanoparticle modified capsules was measured using scanning photo-induced impedance microscopy 2 (SPIM), which is based on photocurrent measurements at an electrolyte-insulatorsemiconductor (EIS) field-effect structure. High resolution and good sensitivity were achieved using a two-photon effect for charge carrier excitation and organic monolayer modified silicon on sapphire (SOS) as the SPIM substrate. SPIM allowed impedance imaging of collapsed microcapsules with unprecedented detail. SPIM images of capsules labelled with gold nanoparticles (AuNPs) showed a good agreement with the corresponding optical images, including the creases resulting from the collapse of the hollow shells. The significant increase in impedance caused by the impregnation with AuNPs was also verified by conductive Atomic Force Microscopy (C-AFM) measurements in the dry state.

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Section: Introductionmentioning

confidence: 99%

The effect of gold nanoparticles on the impedance of microcapsules visualized by scanning photo-induced impedance microscopy

Wang

Campos

et al. 2016

Electrochimica Acta

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“…Thirdly, particle-based sensors always involve the particle as carrier, which allows for addition of other compounds, such as other fluorophores (e.g. for fluorescence resonance energy transfer, FRET) [12], ligands for colloidal stability or for targeting, or therapeutic compounds [13,14], and thus permits an exceptional tailoring in the design of these systems. In case magnetic nanoparticles are used as carriers the same system could act magnetically guided as drug delivery carrier, which simultaneously monitors the delivered drug [15].…”

Section: Potential Of Particles-based Ion-sensitive Fluorescence Sensorsmentioning

confidence: 99%

Fluorescence-based ion-sensing with colloidal particles

Ashraf

Carrillo‐Carrión

Zhang

et al. 2014

Current Opinion in Pharmacology

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“…This means that with increasing numbers of layers the inner layers are more and more unaffected by hydration [23]. Concerning applications of capsules in biomedical fields, they can generally be divided into delivery and sensing applications [24,25]. A large size of the capsules can be of advantage in cell culture models, as large capsules are easily traceable with optical techniques.…”

Section: Polyelectrolyte Multilayer Capsulesmentioning

confidence: 99%