Biological Approaches for Disease Control in Aquaculture: Advantages, Limitations and Challenges

Pérez‐Sánchez, Tania; Mora‐Sánchez, Brenda; Balcázar, José Luís

doi:10.1016/j.tim.2018.05.002

Cited by 196 publications

(95 citation statements)

References 58 publications

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“…This information could guide the establishment and modulation of a 'healthy' gut microbiome for improving host fitness (Pérez-Sánchez et al, 2018;Xiong, 2018). This information could guide the establishment and modulation of a 'healthy' gut microbiome for improving host fitness (Pérez-Sánchez et al, 2018;Xiong, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Key aims of research on gut microbiota are to understand the underlying ecological mechanisms behind the successions that occur as host aged and to track the source of its commensals. This information could guide the establishment and modulation of a 'healthy' gut microbiome for improving host fitness (Pérez-Sánchez et al, 2018;Xiong, 2018). Despite recent progress, we still lack a basic understanding of the relative importance of external (i.e., environmental variables and species pool) and internal factors (i.e., host selection) in governing the assembly and colonization of gut microbiota in invertebrates.…”

Section: Discussionmentioning

confidence: 99%

“…Which factors govern the assembly of shrimp gut microbiota? It is becoming clear that disease in aquaculture is ascribed to the disruption of pathogen-hostenvironment interactions (Pérez-Sánchez et al, 2018;Xiong, 2018). To determine this, we used a structural equation model (SEM) to evaluate the interplay among rearing water variables, bacterioplankton and gut communities.…”

Section: Introductionmentioning

confidence: 99%

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Spatiotemporal successions of shrimp gut microbial colonization: high consistency despite distinct species pool

Xiong

Xuan

et al. 2019

Environmental Microbiology

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Summary Aquatic animals encounter suites of novel planktonic microbes during their development. Although hosts have been shown to exert strong selection on their gut microbiota from surrounding environment, to what extent and the generality that the gut microbiota and the underlying ecological processes are affected by biotic and abiotic variations are largely unclear. Here, these concerns were explored by coupling spatiotemporal data on gut and rearing water bacterial communities with environmental variables over shrimp life stages at spatially distant locations. Shrimp gut microbiotas significantly changed mirroring their development, as evidenced by gut bacterial signatures of shrimp life stage contributing 95.5% stratification accuracy. Shrimp sourced little (2.6%–15.8%) of their gut microbiota from their rearing water. This microbial resistance was reflected by weak compositional differences between shrimp farming spatially distinct locations where species pools were distinct. Consistently, the assembly of shrimp gut microbiota was not adequately explained by the rearing water variables and bacterial community, but rather by host‐age‐associated biotic features. The successions of shrimp gut microbiota were droved by replacement (βsim), rather than by nestedness (βnes), while those of bacterioplankton communities were equally governed by replacement and nestedness. Our study highlights how shrimp gut bacterial community assembly is coupled to their development, rearing species pool, and that the successional pattern of host‐associated communities is differed from that of free‐living bacteria.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Spatiotemporal successions of shrimp gut microbial colonization: high consistency despite distinct species pool

Xiong

Xuan

et al. 2019

Environmental Microbiology

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“…As wild fish stock harvests have reached biologically unsustainable limits, aquaculture has grown to provide over half of all fish consumed worldwide [1]. However, intensive aquaculture facilities are prone to disease outbreaks and the high mortality rate in immunologically immature juveniles, in which vaccination is unpractical, constitutes a primary bottleneck for fish production [2-4]. These recurrent complications prompt the prophylactic or therapeutic use of antibiotics and chemical disinfectants to prevent fish diseases [5, 6] but may lead to final consumer safety risks, environmental pollution and spread of antibiotic resistance [7].…”

Section: Introductionmentioning

confidence: 99%

Gnotobiotic rainbow trout (Oncorhynchus mykiss) model reveals endogenous bacteria that protect againstFlavobacterium columnareinfection

Pérez-Pascual

Vendrell-Fernández

Audrain

et al. 2020

Preprint

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25 26 27 The health and environmental risks associated with antibiotic use in aquaculture have promoted 28 bacterial probiotics as an alternative approach to control fish infections in vulnerable larval and 29 juvenile stages. However, evidence-based identification of probiotics is often hindered by the 30 complexity of bacteria-host interactions and host variability in microbiologically uncontrolled 31 conditions. While these difficulties can be partially resolved using gnotobiotic models 32 harboring no or reduced microbiota, most host-microbe interaction studies are carried out in 33 animal models with little relevance for fish farming. Here we studied host-microbiota-pathogen 34 interactions in a germ-free and gnotobiotic model of rainbow trout (Oncorhynchus mykiss), one 35 of the most widely cultured salmonids. We demonstrated that germ-free larvae raised in sterile 36 conditions displayed no significant difference in growth after 35 days compared to 37 conventionally-raised larvae, but were extremely sensitive to infection by Flavobacterium 38 columnare, a common freshwater fish pathogen causing major economic losses worldwide. 39

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“…Policy on antibiotics in aquaculture is becoming more strict, and antibiotics are forbidden in some countries (Lulijwa et al 2019). Finding antibiotic alternatives in this field is the focus of the current research (Pérez-Sánchez et al 2018) due to the promising market they represent. To reduce the selective pressure exerted on bacteria strains, novel strategies target natural products that inhibit the expression of virulence genes without exerting a strong bactericide activity (Moloney 2016;Spellberg and Gilbert 2014).…”

Section: Introductionmentioning

confidence: 99%

Potential of fascaplysin and palauolide from Fascaplysinopsis cf reticulata to reduce the risk of bacterial infection in fish farming

Mai¹,

Toullec

Wynsberge

et al. 2019

Fish Aquatic Sci

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Marine natural products isolated from the sponge Fascaplysinopsis cf reticulata, in French Polynesia, were investigated as an alternative to antibiotics to control pathogens in aquaculture. The overuse of antibiotics in aquaculture is largely considered to be an environmental pollution, because it supports the transfer of antibiotic resistance genes within the aquatic environment. One environmentally friendly alternative to antibiotics is the use of quorum sensing inhibitors (QSIs). Quorum sensing (QS) is a regulatory mechanism in bacteria which control virulence factors through the secretion of autoinducers (AIs), such as acyl-homoserine lactone (AHL) in gramnegative bacteria. Vibrio harveyi QS is controlled through three parallel pathways: HAI-1, AI-2, and CAI-1. Bioassayguided purification of F. cf reticulata extract was conducted on two bacterial species, i.e., Tenacibaculum maritimum and V. harveyi for antibiotic and QS inhibition bioactivities. Toxicity bioassay of fractions was also evaluated on the freshwater fish Poecilia reticulata and the marine fish Acanthurus triostegus. Cyclohexanic and dichloromethane fractions of F. cf reticulata exhibited QS inhibition on V. harveyi and antibiotic bioactivities on V. harveyi and T. maritimum, respectively. Palauolide (1) and fascaplysin (2) were purified as major molecules from the cyclohexanic and dichloromethane fractions, respectively. Palauolide inhibited QS of V. harveyi through HAI-1 QS pathway at 50 μg ml-1 (26 μM), while fascaplysin affected the bacterial growth of V. harveyi (50 μg ml-1) and T. maritimum (0.25 μg). The toxicity of fascaplysin-enriched fraction (FEF) was evaluated and exhibited a toxic effect against fish at 50 μg ml-1. This study demonstrated for the first time the QSI potential of palauolide (1). Future research may assess the toxicity of both the cyclohexanic fraction of the sponge and palauolide (1) on fish, to confirm their potential as alternative to antibiotics in fish farming.

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Biological Approaches for Disease Control in Aquaculture: Advantages, Limitations and Challenges

Cited by 196 publications

References 58 publications

Spatiotemporal successions of shrimp gut microbial colonization: high consistency despite distinct species pool

Spatiotemporal successions of shrimp gut microbial colonization: high consistency despite distinct species pool

Gnotobiotic rainbow trout (Oncorhynchus mykiss) model reveals endogenous bacteria that protect againstFlavobacterium columnareinfection

Potential of fascaplysin and palauolide from Fascaplysinopsis cf reticulata to reduce the risk of bacterial infection in fish farming

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