Biological Bases for Cancer Dose-Response Extrapolation Procedures

Abstract

from treatment with mutagenic agents Thus, the equations describing incidence as a function of exposure to cardnogenic agents include two separate terms, one accounting for mutagenic and one for mitogenic stimuli. At high exposures these interact, producing synergism and high incidence rates, but at low exposures they are effectively independent. The multis modelsthat are now used include only terms corresponding to the mutanstimuli and thus fail to adequately describe incidence at high dose rates Biologically based models attempt to include mitogenic effects, as well; they are usualy nUited by data availability.