Biological, biochemical and genotoxic effects of Sb in the midge Chironomus sancticaroli Strixino and Strixino, 1981 (Diptera: Chironomidae)

Morais, Gisele dos Santos; Vieira, Thalita Bastida; Santos, Gustavo Souza; Baika, Loana Mara; Cestari, Marta Margarete; Grassi, Marco Tadeu; Navarro-Silva, Mário Antônio

doi:10.1016/j.ecoenv.2019.03.080

Cited by 21 publications

(4 citation statements)

References 52 publications

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“…As pollution, and in particular heavy metal pollution, becomes more prevalent it becomes increasingly important to understand its effect on the biology of vector mosquitoes. Metal pollution is a common genotoxicant affecting a number of organisms, including mosquitoes [34][35][36]. In terms of reproduction, it is unclear as to whether exposure to heavy metals affects males, females or both.…”

Section: Discussionmentioning

confidence: 99%

Second generation effects of larval metal pollutant exposure on reproduction, longevity and insecticide tolerance in the major malaria vector Anopheles arabiensis (Diptera: Culicidae)

2020

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Background: Members of the Anopheles gambiae complex breed in clean, sunlit temporary bodies of water. Anthropogenic pollution is, however, altering the breeding sites of the vectors with numerous biological effects. Although the effects of larval metal pollution have previously been examined, this study aims to assess the transgenerational effects of larval metal pollution on the major malaria vector An. arabiensis. Methods: Two laboratory strains of An. arabiensis, SENN (insecticide-susceptible) and SENN-DDT (insecticide-resistant), were used in this study. After being bred in water polluted with either cadmium chloride, copper nitrate or lead nitrate, several life history characteristics that can have epidemiological implications (fertility, apoptotic damage to reproductive structures, adult longevity and insecticide tolerance) were examined in the adults and compared to those of adults bred in clean water. Results: All metal treatments reduced fecundity in SENN, but only lead treatment reduced fertility in SENN-DDT. Cadmium chloride exposure resulted in apoptosis and deformation of the testes in both strains. After breeding generation F0 in polluted water, F1 larvae bred in clean water showed an increase in longevity in SENN-DDT adult females. In contrast, after breeding the F0 generation in polluted water, longevity was reduced after cadmium and copper exposure in the F1 generation. Larval metal exposure resulted in an increase in insecticide tolerance in adults of the SENN strain, with SENN-DDT adults gaining the greatest fold increase in insecticide tolerance. Conclusions: This study demonstrates that a single exposure to metal pollution can have transgenerational effects that are not negated by subsequent breeding in clean water.

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Section: Discussionmentioning

confidence: 99%

Second generation effects of larval metal pollutant exposure on reproduction, longevity and insecticide tolerance in the major malaria vector Anopheles arabiensis (Diptera: Culicidae)

2020

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“…Although antimony becomes increasingly important for industry and medicine, the molecular mechanisms of antimony toxicity remain poorly understood but seem to be similar to those described for related metalloid arsenic. It has been demonstrated by several groups that Sb(III) and Sb(V) induce oxidative stress manifested by increased levels of reactive oxygen species (ROS), protein carbonylation, lipid peroxidation and mitochondrial dysfunction in animals and plants [ 16 , 17 , 18 , 19 , 20 ]. Sb(III) displays a high affinity to sulfhydryl groups and therefore is readily complexed in the cytoplasm by cysteine-rich peptides, like glutathione (GSH) and trypanothione (TSH), followed by sequestration of resulting Sb(III)-thiol conjugates into the intracellular compartments or out of the cell [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Complex Mechanisms of Antimony Genotoxicity in Budding Yeast Involves Replication and Topoisomerase I-Associated DNA Lesions, Telomere Dysfunction and Inhibition of DNA Repair

Litwin

Mucha

Pilarczyk

et al. 2021

IJMS

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Antimony is a toxic metalloid with poorly understood mechanisms of toxicity and uncertain carcinogenic properties. By using a combination of genetic, biochemical and DNA damage assays, we investigated the genotoxic potential of trivalent antimony in the model organism Saccharomyces cerevisiae. We found that low doses of Sb(III) generate various forms of DNA damage including replication and topoisomerase I-dependent DNA lesions as well as oxidative stress and replication-independent DNA breaks accompanied by activation of DNA damage checkpoints and formation of recombination repair centers. At higher concentrations of Sb(III), moderately increased oxidative DNA damage is also observed. Consistently, base excision, DNA damage tolerance and homologous recombination repair pathways contribute to Sb(III) tolerance. In addition, we provided evidence suggesting that Sb(III) causes telomere dysfunction. Finally, we showed that Sb(III) negatively effects repair of double-strand DNA breaks and distorts actin and microtubule cytoskeleton. In sum, our results indicate that Sb(III) exhibits a significant genotoxic activity in budding yeast.

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“…During the national health and nutrition survey, it was found that the levels of serum T4 and TSH were correlated with the metabolites of chlorpyrifos poisoning in urine. In addition, chlorpyrifos also has high toxicity to aquatic organisms and other non target organisms, which can significantly reduce the population of earthworms and termites in the soil, and inhibit the number and function of bacteria, fungi, actinomycetes and other microorganisms in the soil [5][6].…”

Section: Introduction To Chlorpyrifosmentioning

confidence: 99%

Environmental Biological Effects of Chlorpyrifos based on Big Data Technology

2020

AJEB

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Chlorpyrifos is one of the major pesticides used in rice fields in China at present. It has great toxicity to benthos, and its half-life of hydrolysis and photolysis is nearly one month. Affected by the expansion of rice field area, the concentration of chlorpyrifos poisoning in rice field drainage is increasing, so it is urgent to effectively degrade chlorpyrifos poisoning in salinized rice field. Therefore, this paper analyzes the environmental biological effects(EBE) of chlorpyrifos based on big data technology(BDT); The degradation ability of chlorpyrifos degrading bacteria in soil was measured, and the influence of chlorpyrifos degrading bacteria on soil enzyme activity and the number of soil microorganisms was discussed. The quantitative analysis of chlorpyrifos and TCP was carried out through BDT, which is of great significance for the improvement of pesticide contaminated soil in the future.

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Biological, biochemical and genotoxic effects of Sb in the midge Chironomus sancticaroli Strixino and Strixino, 1981 (Diptera: Chironomidae)

Cited by 21 publications

References 52 publications

Second generation effects of larval metal pollutant exposure on reproduction, longevity and insecticide tolerance in the major malaria vector Anopheles arabiensis (Diptera: Culicidae)

Second generation effects of larval metal pollutant exposure on reproduction, longevity and insecticide tolerance in the major malaria vector Anopheles arabiensis (Diptera: Culicidae)

Complex Mechanisms of Antimony Genotoxicity in Budding Yeast Involves Replication and Topoisomerase I-Associated DNA Lesions, Telomere Dysfunction and Inhibition of DNA Repair

Environmental Biological Effects of Chlorpyrifos based on Big Data Technology

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