Biological Disposition of some Antimonyl Antibilharzial Drugs: Sodium Antimony-2,3-Meso-Dimercapto-Succinate (Astiban®) in Animals Infected with Schistosoma Mansoni *

Pharmacokinetic and toxicological studies of antimony dextran glycoside (RL‐712)

“…With all drugs antimony was localized to the greatest extent in the liver. Browne & Schulert (1964) also found that most of the antimony was stored in the liver of the hamsters 24 h after a single injection of either antimony dimercaptosuccinate (astiban) or tartar emetic. Abdallah & Saif (1962) concluded that in man there is a strong tendency for trivalent antimony to be retained in the tissues for long periods (up to 50 days) and in very high concentrations, especially in the liver.…”

“…Drugs may be found effective in vitro, but ineffective in man, because they are rapidly excreted. Browne & Schulert (1964) treated mice and hamsters with mSb-labelled astiban. Sixty-five per cent of the injected dose was recovered in the urine of hamsters after 48 h and faecal excretion was about 6% in the same period.…”

The application of X‐ray analysis in the transmission electron microscope to a study of drug distribution in the parasite Schistosoma monsoni (Platyhelminthes)

“…Data from the experiments of Browne & Schulert (1963, 1964 indicate that the female worms accumulate more antimony than the males and they reported a total concentration in females of 33.5 pg of Sb per gram of wet tissue following injections of 50 mg/kg of antimony dimercaptosuccinate per day for 3 days. The use of labelled Astiban and autoradiographic techniques by Browne & Schulert (1964) enabled them to confirm the greater accumulation of antimony in the female although the precise tissue localization was not described. Similar results were obtained by Khayyal (1964) and Molokhia & Smith (1969).…”

Pharmacology of New AntImalarial Drugs: RC 12, Sodium Antimony Salt of Astiban and Kethoxal-bis- Thiosemicarbazone

“…Like other antimalarial compounds, WR 7035 was developed for the treatment of schistosomiasis [3,4], It was synthesized in 1954 by Friedheim et al [3]. Its toxicity is less than other antimalarial compounds.…”